Polycythemia vera differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 6: | Line 6: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
Polycythemia vera must be differentiated from a variety of other conditions. | Polycythemia vera must be differentiated from a variety of other conditions.<ref name="pmid25611051">{{cite journal| author=Tefferi A, Barbui T| title=Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management. | journal=Am J Hematol | year= 2015 | volume= 90 | issue= 2 | pages= 162-73 | pmid=25611051 | doi=10.1002/ajh.23895 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25611051 }} </ref><ref name="pmid16879015">{{cite journal| author=Sanchez S, Ewton A| title=Essential thrombocythemia: a review of diagnostic and pathologic features. | journal=Arch Pathol Lab Med | year= 2006 | volume= 130 | issue= 8 | pages= 1144-50 | pmid=16879015 | doi=10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16879015 }} </ref><ref name="pmid24729196">{{cite journal| author=Jabbour E, Kantarjian H| title=Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management. | journal=Am J Hematol | year= 2014 | volume= 89 | issue= 5 | pages= 547-56 | pmid=24729196 | doi=10.1002/ajh.23691 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24729196 }} </ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! | !Disease | ||
!Etiology | !Etiology | ||
!Symptoms | !Symptoms | ||
!Signs | |||
!Laboratory abnormalities | !Laboratory abnormalities | ||
!Treatment | !Treatment | ||
!Other associated abnormalities | !Other associated abnormalities | ||
| Line 25: | Line 25: | ||
* [[Headache]] | * [[Headache]] | ||
* [[Stroke]]-like symptoms | * [[Stroke]]-like symptoms | ||
| | |||
* [[Ruddy face]] | |||
* [[Splenomegaly]] | |||
| | | | ||
* Elevated [[hemoglobin]] | * Elevated [[hemoglobin]] | ||
* Elevated [[red blood cell]] mass | * Elevated [[red blood cell]] mass | ||
* Elevated [[white blood cell]] count and [[platelet]] count in some cases (panmyelosis) | * Elevated [[white blood cell]] count and [[platelet]] count in some cases (panmyelosis) | ||
| | | | ||
* [[Aspirin]] | * [[Aspirin]] | ||
| Line 54: | Line 54: | ||
* [[Fatigue]] | * [[Fatigue]] | ||
* Bleeding due to dysfunctional platelets and acquired [[von Willebrand disease]] | * Bleeding due to dysfunctional platelets and acquired [[von Willebrand disease]] | ||
| | | | ||
* [[Splenomegaly]] | * [[Splenomegaly]] | ||
* Bruising | * Bruising | ||
| | |||
* Elevated total [[platelet]] count | |||
| | | | ||
* [[Aspirin]] | * [[Aspirin]] | ||
| Line 76: | Line 76: | ||
* [[Infection|Infections]] | * [[Infection|Infections]] | ||
* [[Fever]] | * [[Fever]] | ||
| | |||
* [[Splenomegaly]] | |||
| | | | ||
* Elevated total [[white blood cell count]] | * Elevated total [[white blood cell count]] | ||
* Elevated [[red blood cell]] count and [[platelet]] count occasionally | * Elevated [[red blood cell]] count and [[platelet]] count occasionally | ||
* Increased proportion of metamyelocytes and other [[white blood cells]] at various stages of maturation | * Increased proportion of metamyelocytes and other [[white blood cells]] at various stages of maturation | ||
| | | | ||
* [[Imatinib]] | * [[Imatinib]] | ||
| Line 100: | Line 100: | ||
* [[Abdominal pain]] | * [[Abdominal pain]] | ||
* Early satiety | * Early satiety | ||
| | | | ||
* [[Splenomegaly]] | * [[Splenomegaly]] | ||
| Line 109: | Line 105: | ||
* [[Pallor]] | * [[Pallor]] | ||
* [[Bruising]] | * [[Bruising]] | ||
| | |||
* Decreased [[hemoglobin]] (anemia) | |||
* Decreased [[platelet]] count (thrombocytopenia) | |||
* Decreased [[white blood cell]] count (leukopenia) | |||
| | | | ||
* [[Hydroxyurea]] | * [[Hydroxyurea]] | ||
| Line 129: | Line 129: | ||
* [[Fatigue]] | * [[Fatigue]] | ||
* [[Shortness of breath]] | * [[Shortness of breath]] | ||
| | | | ||
* [[Crackles]] | * [[Crackles]] | ||
| Line 137: | Line 134: | ||
* [[Tachypnea]] | * [[Tachypnea]] | ||
* [[Tachycardia]] | * [[Tachycardia]] | ||
| | |||
* Elevated [[hemoglobin]] | |||
* Increased [[erythropoietin]] level | |||
| | | | ||
* Treatment of underlying cause of [[hypoxia]] | * Treatment of underlying cause of [[hypoxia]] | ||
| Line 149: | Line 149: | ||
|- | |- | ||
|} | |} | ||
==References== | ==References== | ||
Revision as of 14:15, 27 August 2018
|
Polycythemia vera Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia vera differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Polycythemia vera differential diagnosis |
|
Risk calculators and risk factors for Polycythemia vera differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]; Shyam Patel [3]
Overview
Polycythemia vera must be differentiated from other myeloproliferative neoplasms, such as chronic myelogenous leukemia, essential thrombocythemia, and primary myelofibrosis. Polycythemia vera must also be differentiated from secondary polycythemia, which is usually due to chronic hypoxia. Each of these conditions have different etiologies, symptoms, laboratory abnormalities, physical exam findings, and treatments.
Differential Diagnosis
Polycythemia vera must be differentiated from a variety of other conditions.[1][2][3]
| Disease | Etiology | Symptoms | Signs | Laboratory abnormalities | Treatment | Other associated abnormalities |
|---|---|---|---|---|---|---|
| Polycythemia vera (PV) |
|
|
|
| ||
| Essential thrombocythemia (ET) |
|
|
|
|
| |
| Chronic myeloid leukemia (CML) |
|
|
| |||
| Primary myelofibrosis (PMF) |
|
|
|
| ||
| Secondary polycythemia |
|
|
|
|
References
- ↑ Tefferi A, Barbui T (2015). "Polycythemia vera and essential thrombocythemia: 2015 update on diagnosis, risk-stratification and management". Am J Hematol. 90 (2): 162–73. doi:10.1002/ajh.23895. PMID 25611051.
- ↑ Sanchez S, Ewton A (2006). "Essential thrombocythemia: a review of diagnostic and pathologic features". Arch Pathol Lab Med. 130 (8): 1144–50. doi:10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2. PMID 16879015.
- ↑ Jabbour E, Kantarjian H (2014). "Chronic myeloid leukemia: 2014 update on diagnosis, monitoring, and management". Am J Hematol. 89 (5): 547–56. doi:10.1002/ajh.23691. PMID 24729196.