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__NOTOC__
==Differentiating Pancytopenia from Other Diseases==
{{CMG}}; '''Associate Editor-In-Chief:''' [[User:Farbod Zahedi Tajrishi|Farbod Zahedi Tajrishi, M.D.]]
* Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
* There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing ([[complete blood count]]).


==Overview==
{|
[[Thrombocytopenia]] has a broad range of potential causes. While a good [[History and Physical examination|history and physical examination]] can be helpful to diagnose some of these causes such as drug-induced thrombocytopenia, they usually don't suffice and further evaluation is often needed. There are also some useful points that may guide the [[physician]] to an appropriate [[diagnosis]]. For example, [[asymptomatic]], isolated [[thrombocytopenia]] most probably suggests [[Idiopathic thrombocytopenic purpura|ITP]], while [[thrombocytopenia]] in critically ill, hospitalized patients is usually suggestive of [[Iatrogenesis|iatrogenic]] causes (eg. [[dilution]]), [[platelet]] consumption, [[bone marrow suppression]] from [[infection]]/[[sepsis]], or even [[drug-induced thrombocytopenia]]. One should consider however, that a wide variety of other conditions such as [[autoimmune disorders]], [[nutrient]] deficiencies, [[thrombotic microangiopathies]] could all as well cause [[thrombocytopenia]].
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
 
! colspan="2" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
==Differential Diagnosis==
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
{| class="wikitable"
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! rowspan="2" |Category
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
!
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! rowspan="2" |Disease
! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
! rowspan="2" |History and symptoms
! colspan="9" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
! rowspan="2" |Physical exam
! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! colspan="3" |Laboratory findings
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! rowspan="2" |Pathology
! rowspan="2" |Other specifics
|-
|
|[[White blood cells|WBC]] changes
|[[Red blood cell|RBC/]][[hemoglobin]]<nowiki/>changes
|other findings
|-
| rowspan="2" |'''Cardiovascular'''
|
|[[endocarditis]]<ref name="abc">Infective endocarditis. Wikipedia (2015). https://en.wikipedia.org/wiki/Infective_endocarditis Accessed on September 24, 2015</ref>
|
* [[Rigors]]
* [[Fever|Fevers]]
* [[Chills]]
* [[Anorexia]]
* [[Malaise]]
* [[Fatigue]]
* [[Weight loss]]
* [[Embolism|Embolic symptoms]]
|'''Skin'''
* [[Petechiae]]
* [[Splinter hemorrhages]]
* [[Osler's nodes]]
* [[Janeway lesion|Janeway lesions]]
Oral Cavity
* [[Periodontal diseases|Periodontal]] abnormalities
'''Eyes'''
* [[Conjunctival hemorrhage]]
* [[Roth's spot|Roth's spots]] in the [[retina]]
'''Ear Nose and Throat'''
* Bobbing of the [[uvula]] may be present among patients with new onset [[aortic regurgitation]].
'''Cardiovascular'''
* Heart [[Murmur|murmurs]]
* Wide [[pulse pressure]]
'''Lungs'''
* [[Rales]] as a result of [[heart failure]]
'''Abdomen'''
* [[Abdominal pain]] and [[reduced bowel sounds]] due to mesenteric embolization or [[ileus]]
* [[Splenomegaly]]
* [[Flank pain]] as a result of an [[embolus to the kidney]].
'''Neurologic'''
* [[Septic emboli]] may result in [[stroke]] and focal neurologic findings
* [[Seizures]]
* [[Intracranial hemorrhage]]
|    ↑
|<nowiki>-</nowiki>
|
* ↑ [[Erythrocyte sedimentation rate|ESR]]
* ↑ [[Rheumatoid factor|RF]], [[Blood urea nitrogen|BUN]] and [[Creatinine|Cr]] may also be present
|
'''Pathological Criteria'''
* Microorganisms demonstrated by culture or histological examination of a vegetation, a vegetation that has embolized, or an intracardiac abscess specimen
: OR
* Pathological lesions; vegetation or intracardiac abscess confirmed by histological examination showing active endocarditis
|'''Diagnostic criteria:<ref name="Durack">{{cite journal | author = Durack D, Lukes A, Bright D | title = New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. | journal = Am J Med | volume = 96 | issue = 3 | pages = 200-9 | year = 1994 | id = PMID 8154507}}</ref>'''
 
'''''Criteria for Rejecting the Diagnosis'''''
* Firm alternate diagnosis to infective endocarditis
* Resolution of infective endocarditis syndrome in under 4 days on antibiotics
* '''''Does not meet the criteria below:'''''
 
'''''Criteria for Definitive Endocarditis'''''
 
The Duke Clinical Criteria for definitive infective endocarditis require either:
* Two major criteria
: OR
* One major and three minor criteria
: OR
* Five minor criteria
 
=== Major Criteria ===
'''1. Positive Blood Culture for Infective Endocarditis'''
: '''A. Typical microorganism consistent with infective endocarditis from 2 separate blood cultures, as noted below:'''
:: ☑ [[Viridans streptococci]], ''[[Streptococcus bovis]]'', '''or'''
:: ☑ [[HACEK]] group, '''or'''
:: ☑ Community-acquired ''[[Staphylococcus aureus]]'' or [[enterococci]], in the absence of a primary focus
: OR
: '''B. Microorganisms consistent with infective endocarditis from persistently positive blood cultures defined as:'''
:: ☑ 2 positive cultures of blood samples drawn >12 hours apart, '''or'''
:: ☑ All of 3 or a majority of 4 separate cultures of blood (with first and last sample drawn 1 hour apart)
'''2. Evidence of endocardial involvement'''
: '''Positive echocardiogram for infective endocarditis defined as:'''
:: ☑ Oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, '''or'''
:: ☑ On implanted material in the absence of an alternative anatomic explanation, '''or'''
:: ☑ Abscess, '''or'''
:: ☑ New partial dehiscence of prosthetic valve
: OR
:: ☑ New valvular regurgitation (worsening or changing of preexisting murmur not sufficient)
'''Minor criteria:'''
: ☑ Predisposition: predisposing heart condition or [[intravenous drug use]]
: ☑ [[Fever]]: temperature > 38.0° C (100.4° F)
: ☑ Vascular phenomena: major arterial emboli, septic pulmonary infarcts, [[mycotic aneurysm]], [[intracranial hemorrhage]], [[Conjunctival hemorrhage|conjunctival hemorrhages]], and [[Janeway lesions]]
: ☑ Immunologic phenomena: [[glomerulonephritis]], [[Osler's nodes]], [[Roth spot|Roth spots]], and [[rheumatoid factor]]
: ☑ Microbiological evidence: positive [[blood culture]] but does not meet a major criterion as noted above (see footnote) or serological evidence of active infection with organism consistent with infectious endocarditis
: ☑ Echocardiographic findings: consistent with infectious endocarditis but do not meet a major criterion as noted above
: '''Footnote:''' It should be noted that the criteria exclude single positive cultures for [[coagulase-negative staphylococci]], diphtheroids, and organisms that do not commonly cause endocarditis.
|-
|
|[[pulmonary embolism]]<ref name="pmid241826422">{{cite journal| author=Cohen AT, Dobromirski M, Gurwith MM| title=Managing pulmonary embolism from presentation to extended treatment. | journal=Thromb Res | year= 2014 | volume= 133 | issue= 2 | pages= 139-48 | pmid=24182642 | doi=10.1016/j.thromres.2013.09.040 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24182642  }}</ref>
|
* [[Dyspnea]]
* [[Pleuritic chest pain]]
* [[Fainting]]
* [[Cough]]
* [[Substernal chest pain]]
* [[Hemoptysis]]
* [[Wheezing]]
* [[Cyanosis]]
* [[Fever]]
|
|
|
|
* ↑ [[D-dimer]]
|
|
* positive findings on [[CT angiography|CT-angiogram]]
|-
| rowspan="2" |'''Chemical/poisoning'''
|
|[[Strontium-89]]
|
|
|
|
|
|
|
|-
|
|[[zinc]]
|
|
|
|
|
|
|
|-
| rowspan="2" |'''Dermatologic'''
|
|[[Cholesterol embolism]]
|'''General:'''
* [[fever]],
* [[myalgia]]
* [[Weight loss#Unintentional weight loss|weight loss]]
'''Organ-dependent:'''
 
Lower extremities
* [[Livedoid vasculitis|livedo reticularis]]
Kidney
* symptoms of [[Renal insufficiency|renal failure]] or [[nephrotic syndrome]]
Gastroinstestinal
* reduced appetite
* nausea and vomiting
* nonspecific [[abdominal pain]]
* [[gastrointestinal hemorrhage]] 
Central nervous system
* [[stroke]]-like symptoms
* [[headache]]
* [[amaurosis fugax]]
* [[paraparesis]]
* [[cauda equina syndrome]]
* loss of control over the [[bladder]], [[rectum]] and skin sensation around the anus
* [[mononeuropathy]].
|
| ↑/-
|↓/-
|
:* ↑ [[Blood urea nitrogen|BUN]] and [[Creatinine|Cr]] in case of renal failure
:* ↑ [[Creatine kinase|CPK]] and [[troponin]] in case of myocardial infarction
:* [[Occult blood|OB]]+ in case of mesenteric ischemia
:* Peripheral [[eosinophilia]]
:* Urinary [[eosinophilia]] in patients with cholesterol-renal disease
:* [[Complement deficiency|Hypocomplementemia]]
:* ↑ [[Erythrocyte sedimentation rate|ESR]]
|<nowiki>-</nowiki>
|
|-
|
|[[Griscelli syndrome|Griscelli syndrome]]
|
* characteristic [[hypopigmentation]]
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|
|
|
|-
| rowspan="5" |'''Ear Nose Throat'''
|
|[[Alport syndrome]]<ref name="pmid8414153">{{cite journal| author=Chugh KS, Sakhuja V, Agarwal A, Jha V, Joshi K, Datta BN et al.| title=Hereditary nephritis (Alport's syndrome)--clinical profile and inheritance in 28 kindreds. | journal=Nephrol Dial Transplant | year= 1993 | volume= 8 | issue= 8 | pages= 690-5 | pmid=8414153 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8414153 }}</ref><ref name="pmid11137428">{{cite journal| author=McCarthy PA, Maino DM| title=Alport syndrome: a review. | journal=Clin Eye Vis Care | year= 2000 | volume= 12 | issue= 3-4 | pages= 139-150 | pmid=11137428 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11137428 }}</ref><ref name="pmid1425373">{{cite journal| author=Andreoli SP, Deaton M| title=Alport's syndrome. | journal=Ear Nose Throat J | year= 1992 | volume= 71 | issue= 10 | pages= 508-11 | pmid=1425373 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1425373 }}</ref><ref name="pmid8238007">{{cite journal| author=Kashtan CE, Michael AF| title=Alport syndrome: from bedside to genome to bedside. | journal=Am J Kidney Dis | year= 1993 | volume= 22 | issue= 5 | pages= 627-40 | pmid=8238007 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8238007 }}</ref><ref name="pmid8327646">{{cite journal| author=Flinter F| title=Molecular genetics of Alport's syndrome. | journal=Q J Med | year= 1993 | volume= 86 | issue= 5 | pages= 289-92 | pmid=8327646 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8327646 }}</ref><ref name="pmid14253732">{{cite journal| author=Andreoli SP, Deaton M| title=Alport's syndrome. | journal=Ear Nose Throat J | year= 1992 | volume= 71 | issue= 10 | pages= 508-11 | pmid=1425373 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1425373 }}</ref><ref name="pmid7819734">{{cite journal| author=Amari F, Segawa K, Ando F| title=Lens coloboma and Alport-like glomerulonephritis. | journal=Eur J Ophthalmol | year= 1994 | volume= 4 | issue= 3 | pages= 181-3 | pmid=7819734 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7819734 }}</ref><ref name="pmid6871140">{{cite journal| author=Govan JA| title=Ocular manifestations of Alport's syndrome: a hereditary disorder of basement membranes? | journal=Br J Ophthalmol | year= 1983 | volume= 67 | issue= 8 | pages= 493-503 | pmid=6871140 | doi= | pmc=PMC1040106 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6871140 }}</ref>
|
{| class="wikitable"
|'''Renal'''
|'''Auditory'''
|'''Ocular'''
|-
|
* Hematuria
* Proteinuria
* Hypertension
* Reduced Creatinine Clearance
|
* Early Tinnitus
* Vertigo
* High-Frequency Progressive Bilateral Hearing Loss
|
* Refractory Error
* Posterior Polymorphous Dystrophy
* Arcus
* Glaucoma
* Vogt’s White Limbal Girdle
* Band Keratopathy
* Lenticonus
* Spherophakia
* Cataracts
* Lens Coloboma
* Anterior Lenticonus
* Flecked Retinopathy of the Macula or Periphery
|}
|
'''Vital signs'''
* [[Systemic hypertension]] may be present
'''Eyes'''
 
[[Fundoscopy]] shows:
* [[Cataract|Cataracts]]
* Subcapsular posterior lens opacities
* [[Lenticonus]]
* Retinal flecks (dot-and-fleck retinopathy)
* Posterior polymorphous corneal dystrophy/corneal epithelial erosions
'''Ears'''
* [[Sensorineural deafness|Sensorineural hearing loss]]
'''Extremities'''
* [[Peripheral edema]]
* [[Leiomyomatosis]]
'''Miscellaneous'''
* [[Anasarca]]
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|
'''Urinalysis'''
* Microscopic [[hematuria]]
* [[Pyuria]]
* Red cell [[casts]]
* Cylindrical [[casts]]
* [[Proteinuria]]
'''Electrolytes and Metabolic'''
* ↑ [[Blood urea nitrogen|BUN]]
* ↑ [[Creatinine|Cr]]
* [[Hypoalbuminemia]]
|<nowiki>-</nowiki>
|'''Diagnostic criteria:'''<ref name="pmid23349312">{{cite journal| author=Savige J, Gregory M, Gross O, Kashtan C, Ding J, Flinter F| title=Expert guidelines for the management of Alport syndrome and thin basement membrane nephropathy. | journal=J Am Soc Nephrol | year= 2013 | volume= 24 | issue= 3 | pages= 364-75 | pmid=23349312 | doi=10.1681/ASN.2012020148 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23349312 }}</ref>
 
{| class="wikitable"
|'''Mandatory Criterion'''
|Persistent Hematuria
|-
|'''Optional Criteria'''
|''Presence of at Least 1 of 4'':
* Positive Family History of Alport's Syndrome
 
* Characteristic Clinical Features
 
* Characteristic Pathology Findings
 
* Genetic Testing
|}
The equivocal or non-characteristic finding of any of the above prompts further work-up until the diagnosis is made or rejected.
|-
| rowspan="4" |[[MYH9]]-associated disorders
|[[Epstein's syndrome]]
|
* [[epistaxis]]
* [[Gastrointestinal bleeding]]
* [[Hypertension]] (due to kidney disease)
* [[Deafness]]
* NO cataract
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|<nowiki>-</nowiki>
|No [[White blood cells|leukocyte]] [[inclusion bodies]]
|<nowiki>-</nowiki>
| rowspan="4" |
* giant platelets on [[Blood film|PBS]]
|-
|[[Fechtner syndrome]]
|Same as [[Alport syndrome]]:
* [[Sensorineural hearing loss|sensorineural deafness]]
* [[ocular]] abnormalities such as [[cataract]]
* [[nephritis]]
 
|
|
|
|
* characteristic [[White blood cells|leukocyte]] [[inclusion bodies]] +
 
* impaired liver function and [[hypercholesterolemia]] in some cases
|<nowiki>-</nowiki>
|-
|May–Hegglin Anomaly
|
|
|
|
|
* characteristic [[White blood cells|leukocyte]] [[inclusion bodies]] +
|<nowiki>-</nowiki>
|-
|[[Sebastian platelet syndrome|Sebastian Syndrome]]
|same hematologic changes as those in the Fechtner syndrome but without the manifestations of [[Alport syndrome]].
|
|
|
|
* characteristic [[White blood cells|leukocyte]] [[inclusion bodies]] +
|<nowiki>-</nowiki>
|-
|'''Endocrine'''
|
|[[Immunodysregulation polyendocrinopathy and enteropathy, X-linked]]
|
|
|
|
|
|
|
|-
| rowspan="4" |'''Gastroenterologic'''
|
|[[Aminoaciduria|Dibasic aminoaciduria type 2]]
|
|
|
|
|
|
|
|-
|
|[[liver failure]]
|
|
|
|
|
|
|
|-
|
|[[Niemann-Pick disease|Niemann-Pick disease type b]]
|
|
|
|
|
|
|
|-
|
|[[portal hypertension]]
|
|
|
|
|
|
|
|-
| rowspan="11" |'''Genetic'''
|
|[[Aicardi-Goutieres syndrome]]
|
|
|
|
|
|
|
|-
|
|[[Chediak-Higashi disease]]
|
* [[Dizziness]]
* [[Weakness]]
* [[Photophobia]]
* [[Tremor]]
* Photosensitive skin
* [[Neuropathy]]
* Frequent infections - [[Staphylococcus aureus]]
* [[Numbness]]
* [[Seizures]]
* [[ataxia]]
* Nosebleeds or easy [[bruising]]
* [[mental retardation]]
|'''Skin'''
* [[Hypopigmentation skin|Hypopigmentation]]
* Silvery hair
'''Eye'''
* [[Nystagmus]]
'''Abdomen'''
* [[Hepatomegaly]]
* [[Splenomegaly]]
'''Neurologic'''
* [[Neuropathy]]
|↓
|<nowiki>-</nowiki>
|
* [[Hypergammaglobulinemia]]
* ↑ [[Bleeding time]]
* ↑ [[bilirubin]]
* Peripheral blood smear - giant granules in neutrophils, eosinophils, and granulocytes
* Bone marrow smear - peroxidase positive giant inclusion bodies in leukocyte precursor cells. The inclusion bodies contain lysosomal enzymes.
|<nowiki>-</nowiki>
|
 
'''CT'''
* Brain and spinal cord atrophy
'''MRI'''
* Brain and spinal cord atrophy
'''EMG'''
* Delayed nerve conduction
'''EEG'''
* May reveal [[seizure]] activity
|-
|
|[[Factor H|complement factor H deficiency]]
|
|
|
|
|
|
|
|-
|
|[[Fanconi anaemia]]
|
|
|
|
|
|
|
|-
|
|[[holocarboxylase synthase deficiency]]
|
|
|
|
|
|
|
|-
|
|[[iminodipeptiduria]]
|
|
|
|
|
|
|
|-
|
|[[Jacobsen syndrome]]
|
|
|
|
|
|
|
|-
|
|[[MELAS]]
|
'''Early symptoms:'''
* [[Muscle weakness]]
* [[Muscle pain]]
* Recurrent [[headaches]]
* [[Loss of appetite]]
* [[Vomiting]]
* [[Seizures]]
* [[Abdominal pain]]
* [[fatigue]]
* [[Difficulty breathing]]
'''Eye'''
* Vision abnormalities
'''Ear'''
* [[Hearing loss]]
'''Extremeties'''
* [[Myoclonus]]
'''Neurologic'''
* [[Stroke]]-like episodes beginning before age 40
* [[hemiparesis]]
* [[Confusion|Altered consciousness]]
* [[Ataxia]]
* [[Seizures]]
* [[Dementia]]
|
|
|<nowiki>-</nowiki>
|
* [[lactic acidosis]]
|<nowiki>-</nowiki>
|
|-
|
|[[Omenn syndrome]]
|
|
|
|
|
|
|
|-
|
|[[TAR syndrome]]
|Absent [[Radius (bone)|radius]]
|
|
|
|
|
|
|-
|
|[[X-linked hyperimmunoglobulin M syndrome]]
|
|
|
|
|
|
|
|-
| rowspan="33" |'''Hematologic'''
|
|[[Acquired pure megakaryocytic aplasia]]
|
|
|
|
|
|
|
|-
|
|[[aplastic anemia]]
|
|
|<nowiki>+ / ↓</nowiki>
|<nowiki>+ / ↓</nowiki>
|
|
|
|-
|
|[[Bernard-Soulier syndrome]]
|
|
|
|
|
|
|
|-
|
|[[Thrombocytopenia|congenital amegakaryocytic thrombocytopenia (CAMT)]]
|
|
|
|
|
|
|
|-
|
|[[disseminated intravascular coagulation]]
|
|
|
|
|
|
|
|-
|
|[[Epstein's syndrome]]
|
|
|
|
|
|
|
|-
|
|[[familial histiocytic reticulosis]]
|
|
|
|
|
|
|
|-
|
|[[Gasser syndrome]]
|
|
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|
|
|
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|-
|
|[[GATA1|GATA1-related cytopenia]]
|
|
|
|
|
|
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|-
|
|[[Glanzmann's thrombasthenia]]
|
|
|
|
|
|
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|-
|
|[[grey platelet syndrome]]
|
|
|
|
|
|
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|-
|
|[[hemolytic uremic syndrome]]
|
|
|
|
|
|
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|-
|
|[[histiocytosis X]]
|
|
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|
|
|
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|-
|
|[[hypersplenism]]
|
|
|
|
|
|
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|-
|
|[[idiopathic thrombocytopenic purpura]]
|
|
|
|
|
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|-
|
|[[Jacobsen syndrome]]
|
|
|
|
|
|
|
|-
|
|[[Kasabach-Merritt syndrome]]
|
|
|
|
|
|
|
|-
|
|[[May-Hegglin anomaly]]
|
|
|
|
|
|
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|-
|
|[[Moschcowitz syndrome]]
|
|
|
|
|
|
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|-
|
|[[myelodysplastic syndrome]]
|
|
|
|
|
|
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|-
|
|[[myelofibrosis]]
|
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|-
|
|[[neonatal alloimmune thrombocytopenia]]
|
|
|
|
|
|
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|-
|
|[[pancytopenia]]
|
|
|
|
|
|
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|-
|
|Paris-Trousseau thrombocytopenia
|
|
|
|
|
|
|
|-
|
|[[paroxysmal nocturnal hemoglobinuria]]
|
|
|
|
|
|
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|-
|
|[[post-transfusion purpura]]
|
|
|
|
|
|
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|-
|
|[[TAR syndrome|radial aplasia-thrombocytopenia syndrome]]
|
|
|
|
|
|
|
|-
|
|[[Sebastian platelet syndrome]]
|
|
|
|
|
|
|
|-
|
|[[Shwachman-Diamond syndrome]]
|
|
|
|
|
|
|
|-
|
|[[thrombotic thrombocytopenic purpura]]
|
|
|
|
|
|
|
|-
|-
|
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
|[[Von Willebrand disease|Von Willebrand disease, platelet type]]
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
|
! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptoms
|
| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
|
|
|
|
|
|-
|-
|
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
|[[Werlhof disease]]
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
|
|
|
|
|
|
|
|-
|-
|
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
|[[Wiskott-Aldrich syndrome]]
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
|
! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |CBC
|
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
|-
|-
| rowspan="5" |'''Iatrogenic'''
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased megakaryocyte proliferation
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Accelerated platelet release
|[[Coronary artery bypass surgery|Cardiac bypass]]
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reduced platelet turnover
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
|
|
|
|
|-
|-
|
! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous thrombocytosis
|[[chemotherapy]]
! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
|
! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" |Polycythemia vera
|[[Intra-aortic balloon pump|intra-aortic balloon pump placement]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" |Primary myelofibrosis
|[[Blood transfusion|massive blood transfusion]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" |Chronic myeloid leukemia
|[[radiation therapy]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
| rowspan="25" |'''Infectious diseases'''
! align="center" style="background:#DCDCDC;" + |[[Myelodysplastic syndrome|Myelodysplastic syndromes]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
|
| align="center" style="background:#F5F5F5;" + |
|[[Congenital syphilis]]
* Unknown
|
* Mutation
|
| align="center" style="background:#F5F5F5;" + | +
|
| align="center" style="background:#F5F5F5;" + | -
|
| align="center" style="background:#F5F5F5;" + | -
|
| align="center" style="background:#F5F5F5;" + | -/+
|
| align="center" style="background:#F5F5F5;" + | +
|
| align="center" style="background:#F5F5F5;" + |Elderly
| align="center" style="background:#F5F5F5;" + |Exposure to
* [[Chemotherapy]]
* [[Radiation therapy]]
* [[Tobacco smoking|Tobacco smoke]]
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |[[Petechia|Petechiae]], [[purpura]], diffuse erythematous rash
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |[[Shortness of breath]], [[fatigue]]
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |
* Ovalomacrocytosis
* Basophilic stippling
* [[Howell-Jolly body]]
* Dysplastic [[Neutrophil|neutrophils]]
| align="center" style="background:#F5F5F5;" + |
* Impaired [[myeloid]] maturation
* [[Congenital dyserythropoietic anemia|Dyserythropoiesis]]
* Dysgranulopoiesis
* Dysmegakaryocytopoiesis
* Hypercellular [[bone marrow]]
* [[Fibrosis]]
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |NA
| align="center" style="background:#F5F5F5;" + |[[Bone marrow examination]] + clinical manifestation
| align="center" style="background:#F5F5F5;" + |
* Might transformed to [[acute leukemia]]
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Acute myeloid leukemia
|[[cytomegalovirus]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! colspan="2" align="center" style="background:#DCDCDC;" |Familial thrombocytosis
|[[Dengue fever]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
|[[ehrlichiosis]]
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
|
! rowspan="19" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis
|[[Epstein-Barr virus]]
! align="center" style="background:#DCDCDC;" + |Anemia/
|
blood loss
|
! align="left" style="background:#DCDCDC;" |
|
* Iron deficiency
|
* Blood loss
|
* Hemolysis
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! rowspan="3" align="center" style="background:#DCDCDC;" |Infection
|[[hantavirus]]
! align="center" style="background:#DCDCDC;" |Chronic infections
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Tuberculosis
|[[hepatitis C]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Acute bacterial and viral infections
|[[HIV]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! rowspan="3" align="center" style="background:#DCDCDC;" |Inflammation
|[[human granulocytic ehrlichiosis]]
! align="center" style="background:#DCDCDC;" |Vasculitides
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Acute pancreatitis
|[[Ehrlichiosis|human monocytotropic ehrlichiosis]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" |Malignancy
|[[lassa fever]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! rowspan="3" align="center" style="background:#DCDCDC;" + |Tissue damage
|[[leptospirosis]]
! align="center" style="background:#DCDCDC;" + |Thermal burns
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Trauma
|[[malaria]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Myocardial infarction
|[[measles]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! rowspan="6" align="center" style="background:#DCDCDC;" + |Medication
|[[mumps]]
! align="center" style="background:#DCDCDC;" + |Myelosuppressive agents
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Vincristine
|[[mycoplasma pneumonia]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Epinephrine, glucocorticoids
|[[Relapsing fever|Oklahoma tick fever]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Interleukin-1B
|[[parvovirus]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |All-trans retinoic acid
|[[Q fever]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Thrombopoietin
|[[rubella]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! rowspan="3" align="center" style="background:#DCDCDC;" + |Other
|sepsis
! align="center" style="background:#DCDCDC;" + |Post-splenectomy or functional asplenia
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Allergic reactions
|[[tick-borne encephalitis]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
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| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
|
! align="center" style="background:#DCDCDC;" + |Exercise
|[[Toxic shock syndrome|toxic shock syndrome (staphylococcal)]]
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
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|
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
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|-
|-
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
|[[varicella]]
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
|[[visceral leishmaniasis]]
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
| rowspan="14" |'''Nutritional/Metabolic'''
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
|[[folate deficiency]]
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
|
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|
|
|-
|
|[[Gaucher disease]]
|
|
|
|
|
|
|
|-
|
|[[holocarboxylase synthase deficiency]]
|
|
|
|
|
|
|
|-
|
|[[iminodipeptiduria]]
|
|
|
|
|
|
|
|-
|
|[[iron deficiency]]
|
|
|
|
|
|
|
|-
|
|[[isovaleric acidaemia]]
|
|
|
|
|
|
|
|-
|
|[[Methylmalonic aciduria|methylmalonic aciduria type 2]]
|
|
|
|
|
|
|
|-
|
|[[CD36|platelet glycoprotein 4 deficiency]]
|
|
|
|
|
|
|
|-
|
|[[platelet glycoprotein Ib deficiency]]
|
|
|
|
|
|
|
|-
|
|[[prolidase deficiency]]
|
|
|
|
|
|
|
|-
|
|[[propionyl-CoA carboxylase deficiency]]
|
|
|
|
|
|
|
|-
|
|[[sea blue histiocytosis]]
|
|
|
|
|
|
|
|-
|
|[[sitosterolemia]]
|
|
|
|
|
|
|
|-
|
|[[vitamin B12 deficiency]]
|
|
|
|
|
|
|
|-
| rowspan="2" |'''Obstetric/Gynecologic'''
|
|[[Eclampsia]], [[pre-eclampsia]]
|
|
|
|
|
|
|
|-
|
|[[HELLP syndrome]]
|
|
|
|
|
|
|
|-
| rowspan="11" |'''Oncologic'''
|
|[[Acute lymphoblastic leukemia]]
|
|
|
|
|
|
|
|-
|
|[[acute myeloid leukemia]]
|
|
|
|
|
|
|
|-
|
|[[acute promyelocytic leukemia]]
|
|
|
|
|
|
|
|-
|
|[[chronic lymphocytic leukaemia]]
|
|
|
|
|
|
|
|-
|
|[[chronic myeloid leukaemia]]
|
|
|
|
|
|
|
|-
|
|[[hairy cell leukaemia]]
|
|
|
|
|
|
|
|-
|
|[[hepatosplenic T-cell lymphoma]]
|
|
|
|
|
|
|
|-
|
|[[lymphoma]]
|
|
|
|
|
|
|
|-
|
|[[myeloma]]
|
|
|
|
|
|
|
|-
|
|[[Non-Hodgkins lymphoma]]
|
|
|
|
|
|
|
|-
|
|[[paraneoplastic syndrome]]
|
|
|
|
|
|
|
|-
| rowspan="2" |'''Overdose/Toxicity'''
|
|[[ethanol]]
|
|
|
|
|
|
|
|-
|
|[[arsenic trioxide]]
|
|
|
|
|
|
|
|-
|'''Pulmonary'''
|
|[[Acute respiratory distress syndrome]]
|
|
|
|
|
|
|
|-
|'''Renal/Electrolyte'''
|
|[[hemolytic uremic syndrome]]
|
|
|
|
|
|
|
|-
| rowspan="10" |'''Rheumatology/Immunology/Allergy'''
|
|[[Anticardiolipin syndrome]]
|
|
|
|
|
|
|
|-
|
|[[antiphospholipid syndrome]]
|
|
|
|
|
|
|
|-
|
|[[autoimmune lymphoproliferative syndrome type 1]]
|
|
|
|
|
|
|
|-
|
|[[autoimmune lymphoproliferative syndrome type 2]]
|
|
|
|
|
|
|
|-
|
|[[Factor H|complement factor H deficiency]]
|
|
|
|
|
|
|
|-
|
|[[Evans syndrome]]
|
|
|
|
|
|
|
|-
|
|[[immunodysregulation polyendocrinopathy and enteropathy, X-linked]]
|
|
|
|
|
|
|
|-
|
|[[macrophage-activation syndrome]]
|
|
|
|
|
|
|
|-
|
|[[neonatal alloimmune thrombocytopenia]]
|
|
|
|
|
|
|
|-
|
|[[systemic lupus erythematosus]]
|
|
|
|
|
|
|
|-
|'''Miscellaneous'''
|
|[[Snakebites]]
|
|
|
|
|
|
|
|}
|}
==References==
{{reflist|2}}
[[Category:Hematology]]
{{WS}}
{{WH}}

Revision as of 01:26, 28 August 2018

Differentiating Pancytopenia from Other Diseases

  • Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
  • There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
Category Condition Etiology Mechanism Inherited Acquried Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs
Lab Findings Imaging
Fever Rash Bleeding BP Splenomegaly Jaundice Other CBC PBS Bone marrow exam PT PTT UA
Increased megakaryocyte proliferation Accelerated platelet release Reduced platelet turnover Plt HB WBC
Autonomous thrombocytosis Hematologic malignancies Essential thrombocythemia
Polycythemia vera
Primary myelofibrosis
Chronic myeloid leukemia
Myelodysplastic syndromes[1]
  • Unknown
  • Mutation
 + - - -/+ + Elderly Exposure to + Petechiae, purpura, diffuse erythematous rash + Nl + + Shortness of breath, fatigue ↓ ↓ ↓ Nl Nl Nl NA Bone marrow examination + clinical manifestation
Acute myeloid leukemia
Familial thrombocytosis
Category Condition Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Inherited Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings
Reactive thrombocytosis Anemia/

blood loss

  • Iron deficiency
  • Blood loss
  • Hemolysis
Infection Chronic infections
Tuberculosis
Acute bacterial and viral infections
Inflammation Vasculitides
Acute pancreatitis
Malignancy
Tissue damage Thermal burns
Trauma
Myocardial infarction
Medication Myelosuppressive agents
Vincristine
Epinephrine, glucocorticoids
Interleukin-1B
All-trans retinoic acid
Thrombopoietin
Other Post-splenectomy or functional asplenia
Allergic reactions
Exercise
Category Condition Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Inherited Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings
  1. ↑ Natelson, Ethan A.; Pyatt, David (2013). "Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog". Advances in Hematology. 2013: 1–11. doi:10.1155/2013/309637. ISSN 1687-9104.
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