Sandbox: wdx causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
Line 5: Line 5:
{|
{|
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! colspan="2" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
!
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
! colspan="9" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Clinical manifestations
Line 15: Line 15:
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
!
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
Line 20: Line 21:
| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
| colspan="4" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Signs
|-
|-
!
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
|-
|-
!
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
Line 37: Line 40:
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Increased megakaryocyte proliferation
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Accelerated platelet release
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow infiltration
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reduced platelet turnover
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow failure
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/
sequestration/
 
redistribution
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
|-
|-
! rowspan="7" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Autonomous thrombocytosis
! rowspan="9" |Hematologic disorders
! rowspan="6" align="center" style="background:#DCDCDC;" |Hematologic malignancies
!Myelodysplastic syndromes (MDS)
! align="center" style="background:#DCDCDC;" |Essential thrombocythemia
|
| align="center" style="background:#F5F5F5;" + |
* Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
* Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
|-
|-
! align="center" style="background:#DCDCDC;" |Polycythemia vera
!
| align="center" style="background:#F5F5F5;" + |
* Acute leukemias
| align="center" style="background:#F5F5F5;" + |
* Chronic leukemias/myeloproliferative neoplasms (MPN)
| align="center" style="background:#F5F5F5;" + |
* Multiple myeloma
| align="center" style="background:#F5F5F5;" + |
* Metastatic cancer
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
* Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
* Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |Primary myelofibrosis
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" |Chronic myeloid leukemia
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
! align="center" style="background:#DCDCDC;" + |[[Myelodysplastic syndrome|Myelodysplastic syndromes]]<ref name="NatelsonPyatt2013">{{cite journal|last1=Natelson|first1=Ethan A.|last2=Pyatt|first2=David|title=Acquired Myelodysplasia or Myelodysplastic Syndrome: Clearing the Fog|journal=Advances in Hematology|volume=2013|year=2013|pages=1–11|issn=1687-9104|doi=10.1155/2013/309637}}</ref>
| align="center" style="background:#F5F5F5;" + |
* Unknown
* Mutation
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | -
| align="center" style="background:#F5F5F5;" + | -
| align="center" style="background:#F5F5F5;" + | -/+
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Elderly
| align="center" style="background:#F5F5F5;" + |Exposure to
* [[Chemotherapy]]
* [[Radiation therapy]]
* [[Tobacco smoking|Tobacco smoke]]
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |[[Petechia|Petechiae]], [[purpura]], diffuse erythematous rash
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |[[Shortness of breath]], [[fatigue]]
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |↓
| align="center" style="background:#F5F5F5;" + |
* Ovalomacrocytosis
* Basophilic stippling
* [[Howell-Jolly body]]
* Dysplastic [[Neutrophil|neutrophils]]
| align="center" style="background:#F5F5F5;" + |
* Impaired [[myeloid]] maturation
* [[Congenital dyserythropoietic anemia|Dyserythropoiesis]]
* Dysgranulopoiesis
* Dysmegakaryocytopoiesis
* Hypercellular [[bone marrow]]
* [[Fibrosis]]
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |Nl
| align="center" style="background:#F5F5F5;" + |NA
| align="center" style="background:#F5F5F5;" + |[[Bone marrow examination]] + clinical manifestation
| align="center" style="background:#F5F5F5;" + |
* Might transformed to [[acute leukemia]]
|-
! align="center" style="background:#DCDCDC;" + |Acute myeloid leukemia
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
Line 230: Line 116:
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! colspan="2" align="center" style="background:#DCDCDC;" |Familial thrombocytosis
!Myelofibrosis
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + | +
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
Line 258: Line 144:
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
!Fanconi anemia
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
!+
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Rash
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Splenomegaly
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Jaundice
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other signs
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |HB
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |WBC
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PBS
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bone marrow exam
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PT
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |PTT
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |UA
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|-
|-
! rowspan="19" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Reactive thrombocytosis
!Aplastic anemia
! align="center" style="background:#DCDCDC;" + |Anemia/
!Immune destruction/suppression
blood loss
!
! align="left" style="background:#DCDCDC;" |
!+
* Iron deficiency
!
* Blood loss
!
* Hemolysis
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
| align="center" style="background:#F5F5F5;" + |
|-
|-
! rowspan="3" align="center" style="background:#DCDCDC;" |Infection
!Dyskeratosis congenital/telomere biology disorders
! align="center" style="background:#DCDCDC;" |Chronic infections
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" + |Tuberculosis
!Shwachman-Diamond syndrome
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Acute bacterial and viral infections
!Paroxysmal nocturnal hemoglobinuria
| align="center" style="background:#F5F5F5;" + |
!Immune destruction/suppression
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! rowspan="3" align="center" style="background:#DCDCDC;" |Inflammation
!Disseminated intravascular coagulation
! align="center" style="background:#DCDCDC;" |Vasculitides
!Consumption
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" + |Acute pancreatitis
! rowspan="5" |Immunology/
| align="center" style="background:#F5F5F5;" + |
Rheumatology
| align="center" style="background:#F5F5F5;" + |
!SLE
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
!
|-
|-
! align="center" style="background:#DCDCDC;" |Malignancy
!Felty syndrome
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! rowspan="3" align="center" style="background:#DCDCDC;" + |Tissue damage
!Wiskott Aldrich syndrome
! align="center" style="background:#DCDCDC;" + |Thermal burns
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" + |Trauma
!GATA2 deficiency
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Myocardial infarction
!Hemophagocytic lymphohistiocytosis (HLH)
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! rowspan="6" align="center" style="background:#DCDCDC;" + |Medication
! rowspan="2" |GI disorders
! align="center" style="background:#DCDCDC;" + |Myelosuppressive agents
!Portal hypertension/cirrhosis
| align="center" style="background:#F5F5F5;" + |
!Splenomegaly
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Vincristine
!Storage diseases (eg, Gaucher)
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
* Splenomegaly
| align="center" style="background:#F5F5F5;" + |
* Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Epinephrine, glucocorticoids
! rowspan="2" |Infections
| align="center" style="background:#F5F5F5;" + |
!Sepsis
| align="center" style="background:#F5F5F5;" + |
!Bone marrow infiltration
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Interleukin-1B
!Viral infection such as HIV, hepatitis, Epstein-Barr virus
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
* Marrow suppression
| align="center" style="background:#F5F5F5;" + |
* Splenomegaly
| align="center" style="background:#F5F5F5;" + |
*
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| +
| align="center" style="background:#F5F5F5;" + |
| +
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
!
!
|-
|-
! align="center" style="background:#DCDCDC;" + |All-trans retinoic acid
! rowspan="4" |Nutritional
| align="center" style="background:#F5F5F5;" + |
!Megaloblastic anemia
| align="center" style="background:#F5F5F5;" + |
|Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
|
| align="center" style="background:#F5F5F5;" + |
| +
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Thrombopoietin
!Excessive alcohol
| align="center" style="background:#F5F5F5;" + |
|Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! rowspan="3" align="center" style="background:#DCDCDC;" + |Other
!Other (eg, copper deficiency, zinc toxicity)
! align="center" style="background:#DCDCDC;" + |Post-splenectomy or functional asplenia
|Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
|-
|-
! align="center" style="background:#DCDCDC;" + |Allergic reactions
!Malnutrition
| align="center" style="background:#F5F5F5;" + |
|Ineffective hematopoiesis
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
|-
|-
! align="center" style="background:#DCDCDC;" + |Exercise
!Medications
| align="center" style="background:#F5F5F5;" + |
!Medications such as:
| align="center" style="background:#F5F5F5;" + |
* Cytotoxic drugs
| align="center" style="background:#F5F5F5;" + |
* Idiosyncratic reactions to medications
| align="center" style="background:#F5F5F5;" + |
!Immune destruction/suppression
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!+
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
| align="center" style="background:#F5F5F5;" + |
!
!
!
!
|-
|-
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category
! colspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition
!
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in blood
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Platelet destruction in spleen
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Inherited
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Congenital
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Acquried
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography
Line 859: Line 746:
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Associated findings
|}
|}
<references />

Revision as of 03:10, 28 August 2018

Differentiating Pancytopenia from Other Diseases

  • Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
  • There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
Category Etiology Mechanism Congenital Acquried Clinical manifestations Para−clinical findings Gold standard Associated findings
Demography History Symptoms Signs
Lab Findings Imaging
Fever Rash Bleeding BP Splenomegaly Jaundice Other CBC PBS Bone marrow exam PT PTT UA
Bone marrow infiltration Bone marrow failure Destruction/

sequestration/

redistribution

Plt HB WBC
Hematologic disorders Myelodysplastic syndromes (MDS)
  • Bone marrow infiltration
  • Ineffective hematopoiesis
  • Acute leukemias
  • Chronic leukemias/myeloproliferative neoplasms (MPN)
  • Multiple myeloma
  • Metastatic cancer
  • Bone marrow infiltration
  • Ineffective hematopoiesis
 + + +
Myelofibrosis Bone marrow infiltration +
Fanconi anemia +
Aplastic anemia Immune destruction/suppression +
Dyskeratosis congenital/telomere biology disorders +
Shwachman-Diamond syndrome +
Paroxysmal nocturnal hemoglobinuria Immune destruction/suppression +
Disseminated intravascular coagulation Consumption +
Immunology/

Rheumatology

SLE
Felty syndrome
Wiskott Aldrich syndrome +
GATA2 deficiency +
Hemophagocytic lymphohistiocytosis (HLH) +
GI disorders Portal hypertension/cirrhosis Splenomegaly +
Storage diseases (eg, Gaucher)
  • Splenomegaly
  • Bone marrow infiltration
 + +
Infections Sepsis Bone marrow infiltration +
Viral infection such as HIV, hepatitis, Epstein-Barr virus
  • Marrow suppression
  • Splenomegaly
 + +
Nutritional Megaloblastic anemia Ineffective hematopoiesis +
Excessive alcohol Ineffective hematopoiesis
Other (eg, copper deficiency, zinc toxicity) Ineffective hematopoiesis
Malnutrition Ineffective hematopoiesis
Medications Medications such as:
  • Cytotoxic drugs
  • Idiosyncratic reactions to medications
 Immune destruction/suppression +
Category Etiology Decreased platelet production Platelet destruction in blood Platelet destruction in spleen Congenital Acquried Demography History Fever Rash Bleeding BP Splenomegaly Jaundice Other signs Plt HB WBC PBS Bone marrow exam PT PTT UA Imaging Gold standard Associated findings
Retrieved from "https://www.wikidoc.org/index.php?title=Sandbox:_wdx_causes&oldid=1492246"