Peripheral neuropathy laboratory findings: Difference between revisions
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** [[serum calcium]], [[K]], [[Na]], [[CL]] | ** [[serum calcium]], [[K]], [[Na]], [[CL]] | ||
* Tests for diagnosis the [[Nutritional Diseases]] and [[vitamin deficiencies]] which may cause peripheral neuropathy include:<ref name="pmid23642720">{{cite journal| author=Hammond N, Wang Y, Dimachkie MM, Barohn RJ| title=Nutritional neuropathies. | journal=Neurol Clin | year= 2013 | volume= 31 | issue= 2 | pages= 477-89 | pmid=23642720 | doi=10.1016/j.ncl.2013.02.002 | pmc=4199287 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23642720 }} </ref><ref name="pmid17324726">{{cite journal| author=Kumar N| title=Nutritional neuropathies. | journal=Neurol Clin | year= 2007 | volume= 25 | issue= 1 | pages= 209-55 | pmid=17324726 | doi=10.1016/j.ncl.2006.11.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17324726 }} </ref><ref name="pmid22970351">{{cite journal| author=Becker DA, Balcer LJ, Galetta SL| title=The Neurological Complications of Nutritional Deficiency following Bariatric Surgery. | journal=J Obes | year= 2012 | volume= 2012 | issue= | pages= 608534 | pmid=22970351 | doi=10.1155/2012/608534 | pmc=3432875 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22970351 }} </ref> | * Tests for diagnosis the [[Nutritional Diseases]] and [[vitamin deficiencies]] which may cause peripheral neuropathy include:<ref name="pmid23642720">{{cite journal| author=Hammond N, Wang Y, Dimachkie MM, Barohn RJ| title=Nutritional neuropathies. | journal=Neurol Clin | year= 2013 | volume= 31 | issue= 2 | pages= 477-89 | pmid=23642720 | doi=10.1016/j.ncl.2013.02.002 | pmc=4199287 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23642720 }} </ref><ref name="pmid17324726">{{cite journal| author=Kumar N| title=Nutritional neuropathies. | journal=Neurol Clin | year= 2007 | volume= 25 | issue= 1 | pages= 209-55 | pmid=17324726 | doi=10.1016/j.ncl.2006.11.001 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17324726 }} </ref><ref name="pmid22970351">{{cite journal| author=Becker DA, Balcer LJ, Galetta SL| title=The Neurological Complications of Nutritional Deficiency following Bariatric Surgery. | journal=J Obes | year= 2012 | volume= 2012 | issue= | pages= 608534 | pmid=22970351 | doi=10.1155/2012/608534 | pmc=3432875 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22970351 }} </ref> | ||
** CBC; serum B12 | **[[ CBC]]; [[serum vitamin B12]] | ||
** Plasma B6 | ** Plasma [[vitamin B6]] | ||
** Plasma B6 | ** Plasma [[vitamin B6]] | ||
** Blood B1 | ** Blood [[vitamin B1]] | ||
** Serum vitamin E | ** Serum [[vitamin E]] | ||
** Serum folate | ** Serum [[folate]] | ||
* Tests for diagnosis the [[heavy Metal]] toxicities which may cause peripheral neuropathy include:<ref name="pmid25184144">{{cite journal| author=Sharma B, Singh S, Siddiqi NJ| title=Biomedical implications of heavy metals induced imbalances in redox systems. | journal=Biomed Res Int | year= 2014 | volume= 2014 | issue= | pages= 640754 | pmid=25184144 | doi=10.1155/2014/640754 | pmc=4145541 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25184144 }} </ref> | * Tests for diagnosis the [[heavy Metal]] toxicities which may cause peripheral neuropathy include:<ref name="pmid25184144">{{cite journal| author=Sharma B, Singh S, Siddiqi NJ| title=Biomedical implications of heavy metals induced imbalances in redox systems. | journal=Biomed Res Int | year= 2014 | volume= 2014 | issue= | pages= 640754 | pmid=25184144 | doi=10.1155/2014/640754 | pmc=4145541 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25184144 }} </ref> | ||
**[[Lead]] | **[[Lead]] | ||
**[[Arsenic]] | **[[Arsenic]] | ||
**Mercury | **[[Mercury]] | ||
**24-hour urine heavy metals panel | **24-hour urine [[heavy metals]] panel | ||
* Tests for diagnosis the diseases which produce [[autoantibodies]] against [[peripheral nerves]] such as [[Guillain-Barré syndrome]] and [[chronic inflammatory demyelinating polyneuropathy]] and [[eaton lambert]] disease:<ref name="pmid8862128">{{cite journal| author=Yuki N, Tagawa Y, Handa S| title=Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. | journal=J Neuroimmunol | year= 1996 | volume= 70 | issue= 1 | pages= 1-6 | pmid=8862128 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8862128 }} </ref><ref name="pmid1645944">{{cite journal| author=Leys K, Lang B, Johnston I, Newsom-Davis J| title=Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. | journal=Ann Neurol | year= 1991 | volume= 29 | issue= 3 | pages= 307-14 | pmid=1645944 | doi=10.1002/ana.410290313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1645944 }} </ref> | * Tests for diagnosis the diseases which produce [[autoantibodies]] against [[peripheral nerves]] such as [[Guillain-Barré syndrome]] and [[chronic inflammatory demyelinating polyneuropathy]] and [[eaton lambert]] disease:<ref name="pmid8862128">{{cite journal| author=Yuki N, Tagawa Y, Handa S| title=Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. | journal=J Neuroimmunol | year= 1996 | volume= 70 | issue= 1 | pages= 1-6 | pmid=8862128 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8862128 }} </ref><ref name="pmid1645944">{{cite journal| author=Leys K, Lang B, Johnston I, Newsom-Davis J| title=Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. | journal=Ann Neurol | year= 1991 | volume= 29 | issue= 3 | pages= 307-14 | pmid=1645944 | doi=10.1002/ana.410290313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1645944 }} </ref> | ||
| Line 35: | Line 35: | ||
**Anti sulfated glucuronyl paragloboside antibodies | **Anti sulfated glucuronyl paragloboside antibodies | ||
* Rheumatologic, Autoimmune, and Vasculitic Disease:<ref name="pmid25299283">{{cite journal| author=Staff NP, Windebank AJ| title=Peripheral neuropathy due to vitamin deficiency, toxins, and medications. | journal=Continuum (Minneap Minn) | year= 2014 | volume= 20 | issue= 5 Peripheral Nervous System Disorders | pages= 1293-306 | pmid=25299283 | doi=10.1212/01.CON.0000455880.06675.5a | pmc=4208100 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25299283 }} </ref> | * Rheumatologic, Autoimmune, and Vasculitic Disease:<ref name="pmid25299283">{{cite journal| author=Staff NP, Windebank AJ| title=Peripheral neuropathy due to vitamin deficiency, toxins, and medications. | journal=Continuum (Minneap Minn) | year= 2014 | volume= 20 | issue= 5 Peripheral Nervous System Disorders | pages= 1293-306 | pmid=25299283 | doi=10.1212/01.CON.0000455880.06675.5a | pmc=4208100 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25299283 }} </ref><ref name="pmid16207324">{{cite journal| author=Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M| title=Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides. | journal=Arthritis Res Ther | year= 2005 | volume= 7 | issue= 5 | pages= R1072-81 | pmid=16207324 | doi=10.1186/ar1789 | pmc=1257438 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16207324 }} </ref><ref name="pmid25954277">{{cite journal| author=Silva de Souza AW| title=Autoantibodies in systemic vasculitis. | journal=Front Immunol | year= 2015 | volume= 6 | issue= | pages= 184 | pmid=25954277 | doi=10.3389/fimmu.2015.00184 | pmc=4406058 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25954277 }} </ref><ref name="pmid20944818">{{cite journal| author=Nam TS, Lee SH, Park MS, Choi KH, Kim JT, Choi SM et al.| title=Mononeuropathy multiplex in a patient with chronic active hepatitis B. | journal=J Clin Neurol | year= 2010 | volume= 6 | issue= 3 | pages= 156-8 | pmid=20944818 | doi=10.3988/jcn.2010.6.3.156 | pmc=2950922 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20944818 }} </ref><ref name="pmid9480721">{{cite journal| author=Wahren M, Tengnér P, Gunnarsson I, Lundberg I, Hedfors E, Ringertz NR et al.| title=Ro/SS-A and La/SS-B antibody level variation in patients with Sjögren's syndrome and systemic lupus erythematosus. | journal=J Autoimmun | year= 1998 | volume= 11 | issue= 1 | pages= 29-38 | pmid=9480721 | doi=10.1006/jaut.1997.0173 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9480721 }} </ref><ref name="pmid25865251">{{cite journal| author=Della-Torre E, Lanzillotta M, Doglioni C| title=Immunology of IgG4-related disease. | journal=Clin Exp Immunol | year= 2015 | volume= 181 | issue= 2 | pages= 191-206 | pmid=25865251 | doi=10.1111/cei.12641 | pmc=4516435 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25865251 }} </ref> | ||
**[[ANA]], [[dsDNA antibodies]] | **[[ANA]], [[dsDNA antibodies]] | ||
**[[Cyclic citrullinated peptide antibody]], [[rheumatoid factor]] | **[[Cyclic citrullinated peptide antibody]], [[rheumatoid factor]] | ||
Revision as of 16:46, 29 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of peripheral neuropathy according to the common causes of it, include:
- Tests for diagnosis the endocrine and metabolic Diseases which may cause peripheral neuropathy include:[1][2]
- Tests for diagnosis the Nutritional Diseases and vitamin deficiencies which may cause peripheral neuropathy include:[3][4][5]
- CBC; serum vitamin B12
- Plasma vitamin B6
- Plasma vitamin B6
- Blood vitamin B1
- Serum vitamin E
- Serum folate
- Tests for diagnosis the heavy Metal toxicities which may cause peripheral neuropathy include:[6]
- Lead
- Arsenic
- Mercury
- 24-hour urine heavy metals panel
- Tests for diagnosis the diseases which produce autoantibodies against peripheral nerves such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy and eaton lambert disease:[7][8]
- Calcium channel autoantibodies to rule out eaton lambert disease
- Anti acidic glycosphingolipids sialosyl paragloboside antibodies
- Anti sialosyl lactosaminyl paragloboside antibodies
- Anti sulfated glucuronyl paragloboside antibodies
- Rheumatologic, Autoimmune, and Vasculitic Disease:[9][10][11][12][13][14]
- ANA, dsDNA antibodies
- Cyclic citrullinated peptide antibody, rheumatoid factor
- Anti neutrophil cytoplasmic antibody
- Myeloperoxidase antibody
- Cryoglobulins
- Hepatitis B and C serology
- Parvovirus serology
- HIV-1 serology
- Proteinase 3 antibody
- Mitochondrial antibody
- SS-A/Ro antibody, SS-B/La antibody
- Thyroid peroxidase antibody
- Kappa/lambda light chains and free with ratio in serum
- Tests for diagnosis the other common causes of peripheral neuropathy include:
References
- ↑ Yu J (2014). "Endocrine disorders and the neurologic manifestations". Ann Pediatr Endocrinol Metab. 19 (4): 184–90. doi:10.6065/apem.2014.19.4.184. PMC 4316409. PMID 25654063.
- ↑ Callaghan B, Feldman E (2013). "The metabolic syndrome and neuropathy: therapeutic challenges and opportunities". Ann Neurol. 74 (3): 397–403. doi:10.1002/ana.23986. PMC 3881591. PMID 23929529.
- ↑ Hammond N, Wang Y, Dimachkie MM, Barohn RJ (2013). "Nutritional neuropathies". Neurol Clin. 31 (2): 477–89. doi:10.1016/j.ncl.2013.02.002. PMC 4199287. PMID 23642720.
- ↑ Kumar N (2007). "Nutritional neuropathies". Neurol Clin. 25 (1): 209–55. doi:10.1016/j.ncl.2006.11.001. PMID 17324726.
- ↑ Becker DA, Balcer LJ, Galetta SL (2012). "The Neurological Complications of Nutritional Deficiency following Bariatric Surgery". J Obes. 2012: 608534. doi:10.1155/2012/608534. PMC 3432875. PMID 22970351.
- ↑ Sharma B, Singh S, Siddiqi NJ (2014). "Biomedical implications of heavy metals induced imbalances in redox systems". Biomed Res Int. 2014: 640754. doi:10.1155/2014/640754. PMC 4145541. PMID 25184144.
- ↑ Yuki N, Tagawa Y, Handa S (1996). "Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG, and SGPG in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy". J Neuroimmunol. 70 (1): 1–6. PMID 8862128.
- ↑ Leys K, Lang B, Johnston I, Newsom-Davis J (1991). "Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome". Ann Neurol. 29 (3): 307–14. doi:10.1002/ana.410290313. PMID 1645944.
- ↑ Staff NP, Windebank AJ (2014). "Peripheral neuropathy due to vitamin deficiency, toxins, and medications". Continuum (Minneap Minn). 20 (5 Peripheral Nervous System Disorders): 1293–306. doi:10.1212/01.CON.0000455880.06675.5a. PMC 4208100. PMID 25299283.
- ↑ Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M (2005). "Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides". Arthritis Res Ther. 7 (5): R1072–81. doi:10.1186/ar1789. PMC 1257438. PMID 16207324.
- ↑ Silva de Souza AW (2015). "Autoantibodies in systemic vasculitis". Front Immunol. 6: 184. doi:10.3389/fimmu.2015.00184. PMC 4406058. PMID 25954277.
- ↑ Nam TS, Lee SH, Park MS, Choi KH, Kim JT, Choi SM; et al. (2010). "Mononeuropathy multiplex in a patient with chronic active hepatitis B." J Clin Neurol. 6 (3): 156–8. doi:10.3988/jcn.2010.6.3.156. PMC 2950922. PMID 20944818.
- ↑ Wahren M, Tengnér P, Gunnarsson I, Lundberg I, Hedfors E, Ringertz NR; et al. (1998). "Ro/SS-A and La/SS-B antibody level variation in patients with Sjögren's syndrome and systemic lupus erythematosus". J Autoimmun. 11 (1): 29–38. doi:10.1006/jaut.1997.0173. PMID 9480721.
- ↑ Della-Torre E, Lanzillotta M, Doglioni C (2015). "Immunology of IgG4-related disease". Clin Exp Immunol. 181 (2): 191–206. doi:10.1111/cei.12641. PMC 4516435. PMID 25865251.
- ↑ Weis J, Brandner S, Lammens M, Sommer C, Vallat JM (2012). "Processing of nerve biopsies: a practical guide for neuropathologists". Clin Neuropathol. 31 (1): 7–23. PMC 3663462. PMID 22192700.
- ↑ Jain J, Singh R, Banait S, Verma N, Waghmare S (2014). "Magnitude of peripheral neuropathy in cirrhosis of liver patients from central rural India". Ann Indian Acad Neurol. 17 (4): 409–15. doi:10.4103/0972-2327.144012. PMC 4251014. PMID 25506162.
- ↑ Arnold R, Issar T, Krishnan AV, Pussell BA (2016). "Neurological complications in chronic kidney disease". JRSM Cardiovasc Dis. 5: 2048004016677687. doi:10.1177/2048004016677687. PMC 5102165. PMID 27867500.
- ↑ Ghosh S, Chaudhury PK, Goswami HK (2006). "An analysis of six cases of acute intermittent porphyria (AIP)". Indian J Psychiatry. 48 (3): 189–92. doi:10.4103/0019-5545.31584. PMC 2932991. PMID 20844651.
- ↑ Misra UK, Kalita J, Nair PP (2008). "Diagnostic approach to peripheral neuropathy". Ann Indian Acad Neurol. 11 (2): 89–97. doi:10.4103/0972-2327.41875. PMC 2771953. PMID 19893645.
- ↑ Argov Z, Mastaglia FL (1979). "Drug-induced peripheral neuropathies". Br Med J. 1 (6164): 663–6. PMC 1598252. PMID 219931.
- ↑ Rison RA, Beydoun SR (2016). "Paraproteinemic neuropathy: a practical review". BMC Neurol. 16: 13. doi:10.1186/s12883-016-0532-4. PMC 4731930. PMID 26821540.