Huntington's disease history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Huntington's disease}} | {{Huntington's disease}} | ||
{{CMG}} | {{CMG}} {{AE}} {{SAH}} | ||
==Overview== | ==Overview== | ||
== History and Symptoms == | == History and Symptoms == | ||
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'''Physicals''' | '''Physicals''' | ||
* Chorea movements: | *Dementia | ||
** Jerky | *Chorea movements: | ||
**Jerky movements | |||
** Uncontrollable movements | **Uncontrollable movements | ||
**Although some exhibit very slow movement and stiffness | |||
* Loss of determination | *Loss of determination | ||
* Speaking is impaired with slurred words and uncontrollable movements of the mouth | *Speaking is impaired with slurred words and uncontrollable movements of the mouth | ||
* Eating and mobility are extremely difficult if not impossible, and full-time care is required. | *Eating and mobility are extremely difficult if not impossible, and full-time care is required. | ||
'''Cognitive''' : Abilities affected are; | '''Cognitive''' : Abilities affected are; | ||
* [[Executive system|Executive function]] | *[[Executive system|Executive function]] | ||
* Planning; cognitive flexibility | *Planning; cognitive flexibility | ||
* Rule acquisition | *Rule acquisition | ||
* Initiating appropriate actions | *Initiating appropriate actions | ||
* Inhibiting inappropriate actions | *Inhibiting inappropriate actions | ||
* Slurring of the words and some uncontrollable movement of the lips | *Slurring of the words and some uncontrollable movement of the lips | ||
* [[Perceptual]] and [[spatial]] skills of self and surrounding environment | *[[Perceptual]] and [[spatial]] skills of self and surrounding environment | ||
* Ability to learn new [[skills]], depending on the affected parts of the brain. | *Ability to learn new [[skills]], depending on the affected parts of the brain. | ||
'''Psychopathological''' : Psychopathological symptoms vary more than cognitive and physical symptoms, and may include | '''Psychopathological''' : Psychopathological symptoms vary more than cognitive and physical symptoms, and may include | ||
* [[Anxiety]] | *[[Anxiety]] | ||
* [[Clinical depression|Depression]] | *[[Clinical depression|Depression]] | ||
* [[Compulsion|Compulsivity]] which can cause [[addictions]] such as [[alcoholism]] and [[gambling]], or [[hypersexuality]]. | * [[Compulsion|Compulsivity]] which can cause [[addictions]] such as [[alcoholism]] and [[gambling]], or [[hypersexuality]]. | ||
* Unable to recognize expressions of [[disgust]] in others and also don't show reactions of disgust to foul odors or tastes.<ref>Mitchell IJ, Heims H, Neville EA, Rickards H. [http://www.neuro.psychiatryonline.org/cgi/content/full/17/1/119 Huntington's disease patients show impaired perception of disgust in the gustatory and olfactory modalities.] ''Journal of Neuropsychiatry and Clinical Neuroscience'', 17:119-121, February 2005. PMID 15746492</ref> The inability to recognize disgust in others appears in carriers of the Huntington gene before symptoms are manifest.<ref>Sprengelmeyer R, Schroeder U, Young AW, Epplen JT. "Disgust in pre-clinical Huntington's disease: a longitudinal study." ''Neuropsychologia.'' 2006;44(4):518-33. Epub 2005 August 11. PMID 16098998</ref> A number of related studies have been published.<ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=%22Huntington+Disease%22%5BMAJR%5D+disgust PubMed search for "Huntington's disease" and "disgust"]</ref> | * Unable to recognize expressions of [[disgust]] in others and also don't show reactions of disgust to foul odors or tastes.<ref>Mitchell IJ, Heims H, Neville EA, Rickards H. [http://www.neuro.psychiatryonline.org/cgi/content/full/17/1/119 Huntington's disease patients show impaired perception of disgust in the gustatory and olfactory modalities.] ''Journal of Neuropsychiatry and Clinical Neuroscience'', 17:119-121, February 2005. PMID 15746492</ref> The inability to recognize disgust in others appears in carriers of the Huntington gene before symptoms are manifest.<ref>Sprengelmeyer R, Schroeder U, Young AW, Epplen JT. "Disgust in pre-clinical Huntington's disease: a longitudinal study." ''Neuropsychologia.'' 2006;44(4):518-33. Epub 2005 August 11. PMID 16098998</ref> A number of related studies have been published.<ref>[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&term=%22Huntington+Disease%22%5BMAJR%5D+disgust PubMed search for "Huntington's disease" and "disgust"]</ref> | ||
Revision as of 21:04, 5 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Syed Ahsan Hussain, M.D.[2]
Overview
History and Symptoms
Although there is no sudden loss of abilities or exhibition of symptoms, there is a progressive decline.
Physicals
- Dementia
- Chorea movements:
- Jerky movements
- Uncontrollable movements
- Although some exhibit very slow movement and stiffness
- Loss of determination
- Speaking is impaired with slurred words and uncontrollable movements of the mouth
- Eating and mobility are extremely difficult if not impossible, and full-time care is required.
Cognitive : Abilities affected are;
- Executive function
- Planning; cognitive flexibility
- Rule acquisition
- Initiating appropriate actions
- Inhibiting inappropriate actions
- Slurring of the words and some uncontrollable movement of the lips
- Perceptual and spatial skills of self and surrounding environment
- Ability to learn new skills, depending on the affected parts of the brain.
Psychopathological : Psychopathological symptoms vary more than cognitive and physical symptoms, and may include
- Anxiety
- Depression
- Compulsivity which can cause addictions such as alcoholism and gambling, or hypersexuality.
- Unable to recognize expressions of disgust in others and also don't show reactions of disgust to foul odors or tastes.[1] The inability to recognize disgust in others appears in carriers of the Huntington gene before symptoms are manifest.[2] A number of related studies have been published.[3]
References
- ↑ Mitchell IJ, Heims H, Neville EA, Rickards H. Huntington's disease patients show impaired perception of disgust in the gustatory and olfactory modalities. Journal of Neuropsychiatry and Clinical Neuroscience, 17:119-121, February 2005. PMID 15746492
- ↑ Sprengelmeyer R, Schroeder U, Young AW, Epplen JT. "Disgust in pre-clinical Huntington's disease: a longitudinal study." Neuropsychologia. 2006;44(4):518-33. Epub 2005 August 11. PMID 16098998
- ↑ PubMed search for "Huntington's disease" and "disgust"