Thrombotic thrombocytopenic purpura classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Classification

TTP may be classified into several subtypes based on: 1.autoantibody against ADAMTS13

• Congenital TTP
• Inherited TTP
• familial TTP
• Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34

1. gene mutations of ADAMTS13

• Hereditary:
• Congenital TTP
• Inherited TTP
• familial TTP
• Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34

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• Acquired: Existence of an inhibitory antibody against ADAMS13 due to the variety of conditions.