Sandbox: wdx causes

Differentiating Leukocytosis from Other Diseases

• Leukocytosis is defined as an elevated white blood cell (WBC) count greater than 11,000 per mm3 (11.0 × 109 per L).
• The most common type of leukocytosis is neutrophilia.
  • Neutrophilia can be defined as an increase in the absolute number of mature neutrophils to greater than 7,000 per mm3 [7.0 × 109 per L].

Category	Condition	Etiology	Mechanism				Congenital	Acquried	Clinical manifestations									Para−clinical findings						Gold standard	Associated findings
									Demography	History	Symptoms			Signs
																		Lab Findings
			Physiologic	increased bone marrow production		demargination of peripheral blood neutrophils					Appearance	Fever	Bleeding	BP	Splenomegaly	Jaundice	Other	CBC			PBS	Bone marrow exam	ESR/CRP
				autonomous	reactive													Plt	HB	WBC
Hematologic	Hereditary neutrophilia
	Chronic idiopathic neutrophilia
	CML
	Polycythemia Vera
	Hemolytic anemia
	Immature thrombocytopenia
Immunology/ Rheumatology	Condition	Etiology	Physiologic				Congenital	Acquried	Demography	History	Appearance	Fever	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	ESR/CRP	Gold standard	Associated findings
	Rheumatoid arthritis
	Juvenile onset rheumatoid arthritis
	adult Still's disease
	Kawasaki disease
	IBD
	Chronic hepatitis
	Sweet syndrome
	Acute Gout
Infections	Acute bacterial																				toxic granulations, Döhle bodies, and cytoplasmic vacuoles in neutrophils
	Chronic
	Viral infection								Children
	granulomatous infections
	bronchiectasis
Metabolic	Diabetic coma
	Acidosis
	Thyroid strom
	Seizures
Category	Condition	Etiology	Physiologic				Congenital	Acquried	Demography	History	Appearance	Fever	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	ESR/CRP	Gold standard	Associated findings
Medications	Steriod	Release of granulocytes from the bone marrow
	Lithium
	Beta agonists
	Cytokines
	Catecholamines (epinephrine)	Stimulation of bone marrow myelopoiesis and/or egress into the circulation
Other	Post splenectomy
	Down syndrome
	Cigarette smoking
	Stress
	Birth
	Pregnancy
	Platelet clumping	Spurious
	Mixed cryoglobulinemia	Spurious
Category	Condition	Etiology	Physiologic				Congenital	Acquried	Demography	History	Appearance	Fever	Bleeding	BP	Splenomegaly	Jaundice	Other signs	Plt	HB	WBC	PBS	Bone marrow exam	ESR/CRP	Gold standard	Associated findings