Thrombotic thrombocytopenic purpura classification: Difference between revisions
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{{CMG}}; {{AE}} {{S.G.}} | {{CMG}}; {{AE}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
TTP may be classified according to ''ADAMTS13'' gene mutations and autoantibody against ADAMTS13 into two subtypes:herditary syndromes,aquired syndromes | |||
==Classification== | ==Classification== | ||
TTP may be classified into several subtypes based on ''ADAMTS13'' gene mutations | TTP may be classified into several subtypes based on ''ADAMTS13'' gene mutations(herditary syndromes) and autoantibodyagainst ADAMTS13(aquired syndromes):<ref name="pmid26581428">{{cite journal |vauthors=Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K |title=ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies |journal=Expert Rev Hematol |volume=9 |issue=2 |pages=209–21 |date=2016 |pmid=26581428 |doi=10.1586/17474086.2016.1122515 |url=}}</ref><ref>{{Cite journal | ||
| author = [[Yoshihiro Fujimura]], [[Masanori Matsumoto]], [[Hideo Yagi]], [[Akira Yoshioka]], [[Taei Matsui]] & [[Koiti Titani]] | | author = [[Yoshihiro Fujimura]], [[Masanori Matsumoto]], [[Hideo Yagi]], [[Akira Yoshioka]], [[Taei Matsui]] & [[Koiti Titani]] | ||
| title = Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome | | title = Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome | ||
Revision as of 22:03, 19 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
TTP may be classified according to ADAMTS13 gene mutations and autoantibody against ADAMTS13 into two subtypes:herditary syndromes,aquired syndromes
Classification
TTP may be classified into several subtypes based on ADAMTS13 gene mutations(herditary syndromes) and autoantibodyagainst ADAMTS13(aquired syndromes):[1][2]
1.Hereditary:
- Congenital TTP
- Inherited TTP
- familial TTP
- Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34 .
2.Acquired
- Existence of an inhibitory antibody against ADAMS13 due to the variety of conditions.
References
- ↑ Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K (2016). "ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies". Expert Rev Hematol. 9 (2): 209–21. doi:10.1586/17474086.2016.1122515. PMID 26581428.
- ↑ Yoshihiro Fujimura, Masanori Matsumoto, Hideo Yagi, Akira Yoshioka, Taei Matsui & Koiti Titani (2002). "Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome". International journal of hematology. 75 (1): 25–34. PMID 11843286. Unknown parameter
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