Ameloblastoma causes: Difference between revisions
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==Overview== | ==Overview== | ||
There are no established causes for ameloblastoma. It is thought that ameloblastoma | There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of [[ameloblastoma]], or it is may be due to increased expression of α5β1 [[integrin]] which participate in the local invasiveness of [[ameloblastoma]]. | ||
==Causes== | ==Causes== | ||
There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro. There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas. A recent study discovered a high frequency of ''BRAF V600E'' mutations in solid/multicystic ameloblastoma. These data suggests drugs targeting mutant ''BRAF'' as potential novel therapies for ameloblastoma. | * There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro. | ||
* There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas. | |||
* A recent study discovered a high frequency of ''BRAF V600E'' mutations in solid/multicystic ameloblastoma. | |||
* These data suggests drugs targeting mutant ''BRAF'' as potential novel therapies for ameloblastoma. | |||
==References== | ==References== | ||
Revision as of 16:24, 28 September 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There are no established causes for ameloblastoma. It is thought that ameloblastoma may be the result of either decreased expression of matrix metalloproteinase-2 which helps in inhibition of the local invasiveness of ameloblastoma, or it is may be due to increased expression of α5β1 integrin which participate in the local invasiveness of ameloblastoma.
Causes
- There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro.
- There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas.
- A recent study discovered a high frequency of BRAF V600E mutations in solid/multicystic ameloblastoma.
- These data suggests drugs targeting mutant BRAF as potential novel therapies for ameloblastoma.