Sandbox:Zahir

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

The disease presents as this that whatever

Pathophysiology

Pathology

• AAA
• BBB
  • CCC

• abc
• def

Diseases		A	B
ABC	Type 1
	Type 2
DEF

Algorithm

Combined Immunodeficiencies Generally Less Pronounced the Severe Combined Immunodeficiency

Low CD4: MHC II Expression?

Low CD8

Low B Cells

Ig: Often Normal

Ig Low

Normal Ig but Low Specific Antibody Response

Absent: MHCII Deficiency

Present: XL: MAGT 1 Def:, AR: LCK Def:, AD: UNC119 Def:

IL2IR Def:

MALT1 Def:

CD8 def:

ZAP70 def:

MHC1 def:

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