Amyotrophic lateral sclerosis overview: Difference between revisions
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==Overview== | ==Overview== | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating Amyotrophic lateral sclerosis from Other Diseases== | |||
==Epidemiology and Demographics== | |||
==Risk Factors== | |||
==Screening== | |||
==Natural History, Complications, and Prognosis== | |||
==Diagnosis== | |||
===Diagnostic Study of Choice=== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Electrocardiogram=== | |||
===X-ray=== | |||
===Echocardiography and Ultrasound=== | |||
===CT scan=== | |||
===MRI=== | |||
===Other Imaging Findings=== | |||
===Other Diagnostic Studies=== | |||
==Treatment== | |||
===Medical Therapy=== | |||
=== Interventions === | |||
===Surgery=== | |||
===Primary Prevention=== | |||
===Secondary Prevention=== | |||
==References== | |||
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{{WikiDoc Help Menu}} | |||
{{WikiDoc Sources}} | |||
[[Category: (name of the system)]] | |||
==Historical Perspective== | ==Historical Perspective== | ||
The word ''amyotrophic'' is present Greek in origin. ''A'' means no or negative, ''myo'' refers to [[muscle]], and ''trophic'' means nourishment. When put together it means "no-muscle-nourishment." ''[[Anatomical terms of location|Lateral]]'' identifies the areas of the [[spinal cord]] where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ([[sclerosis]]) in the region. <ref>[http://www.alsa.org/als/what.cfm What is ALS - The ALS Association] Retrieved October 24, 2006</ref> | The word ''amyotrophic'' is present Greek in origin. ''A'' means no or negative, ''myo'' refers to [[muscle]], and ''trophic'' means nourishment. When put together it means "no-muscle-nourishment." ''[[Anatomical terms of location|Lateral]]'' identifies the areas of the [[spinal cord]] where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening ([[sclerosis]]) in the region. <ref>[http://www.alsa.org/als/what.cfm What is ALS - The ALS Association] Retrieved October 24, 2006</ref> | ||
Revision as of 16:53, 17 October 2018
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Amyotrophic lateral sclerosis Microchapters |
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Differentiating Amyotrophic lateral sclerosis from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Amyotrophic lateral sclerosis overview On the Web |
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American Roentgen Ray Society Images of Amyotrophic lateral sclerosis overview |
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Risk calculators and risk factors for Amyotrophic lateral sclerosis overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Amyotrophic lateral sclerosis Microchapters |
|
Differentiating Amyotrophic lateral sclerosis from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Amyotrophic lateral sclerosis overview On the Web |
|
American Roentgen Ray Society Images of Amyotrophic lateral sclerosis overview |
|
Risk calculators and risk factors for Amyotrophic lateral sclerosis overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[3]
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Amyotrophic lateral sclerosis from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
References
Historical Perspective
The word amyotrophic is present Greek in origin. A means no or negative, myo refers to muscle, and trophic means nourishment. When put together it means "no-muscle-nourishment." Lateral identifies the areas of the spinal cord where portions of the nerve cells that signal and control the muscles are located. As this area degenerates it leads to scarring or hardening (sclerosis) in the region. [1]
Classification
ALS is classified into three general groups, familial ALS, sporadic ALS and Guamanian ALS.
Pathophysiology
The cause of ALS is not known. An important step toward answering that question came in 1993 when scientists discovered that mutations in the gene that produces the Cu/Zn superoxide dismutase (SOD1) enzyme were associated with some cases (approximately 20%) of familial ALS. This enzyme is a powerful antioxidant that protects the body from damage caused by superoxide, a toxic free radical. Free radicals are highly reactive molecules produced by cells during normal metabolism. Free radicals can accumulate and cause damage to DNA and proteins within cells. Although it is not yet clear how the SOD1 gene mutation leads to motor neuron degeneration, researchers have theorized that an accumulation of free radicals may result from the faulty functioning of this gene. Current research, however, indicates that motor neuron death is not likely a result of lost or compromised dismutase activity, suggesting mutant SOD1 induces toxicity in some other way (a gain of function).[2][3]
Causes
Scientists have not found a definitive cause for ALS and the onset of the disease has been linked to several factors, including: a virus; exposure to neurotoxins or heavy metals; DNA defects; immune system abnormalities; and enzyme abnormalities. There is a known hereditary factor in familial ALS (FALS); however, there is no known hereditary component in the 90-95% cases diagnosed as sporadic ALS.
Epidemiology and Demographics
ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
Risk Factors
Risk factors for the development of ALS include; possessing an inherited mutation in chromosome 21, being a child of someone diagnosed with familial ALS, prolonged exposure to a dietary neurotoxin found in the seed of the cycad plant, and being a military veteran.
References
- ↑ What is ALS - The ALS Association Retrieved October 24, 2006
- ↑ Reaume A, Elliott J, Hoffman E, Kowall N, Ferrante R, Siwek D, Wilcox H, Flood D, Beal M, Brown R, Scott R, Snider W (1996). "Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury". Nat Genet. 13 (1): 43–7. PMID 8673102.
- ↑ Bruijn L, Houseweart M, Kato S, Anderson K, Anderson S, Ohama E, Reaume A, Scott R, Cleveland D (1998). "Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1". Science. 281 (5384): 1851–4. PMID 9743498.