Waldenström's macroglobulinemia causes: Difference between revisions
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==Overview== | ==Overview== | ||
Common causes of waldenström's macroglobulinemia include genetic factors such as [[somatic mutation]] in ''MYD88'' and ''CXCR4'', environmental factors such as exposure to farming, pesticides, wood dust, and organic solvents, and immunologic factors such as chronic immune stimulation and [[autoimmune disorder]]s.<ref name= | Common causes of waldenström's macroglobulinemia include genetic factors such as [[somatic mutation]] in ''MYD88'' and ''CXCR4'', environmental factors such as exposure to farming, pesticides, wood dust, and organic solvents, and immunologic factors such as chronic immune stimulation and [[autoimmune disorder]]s.<ref name="UTDR">{{cite journal |vauthors=Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM |title=Oncogenically active MYD88 mutations in human lymphoma |journal=Nature |volume=470 |issue=7332 |pages=115–9 |year=2011 |pmid=21179087 |doi=10.1038/nature09671 |url=}}</ref> | ||
==Causes== | ==Causes== | ||
* | |||
=== Genetic Causes === | |||
*Waldenström Macroglobulinemia is caused by a mutation in the MYD88 gene in 90% of cases and CXR4 in around 30% of patients. | |||
=== Less Common Causes === | |||
Less common causes of waldenström's macroglobulinemia include:<ref name="UTDR">{{cite journal |vauthors=Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM |title=Oncogenically active MYD88 mutations in human lymphoma |journal=Nature |volume=470 |issue=7332 |pages=115–9 |year=2011 |pmid=21179087 |doi=10.1038/nature09671 |url=}}</ref> | |||
:*Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q | :*Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q | ||
:*Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents | :*Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents | ||
:*Chronic immune stimulation and [[autoimmune disorders]] | :*Chronic immune stimulation and [[autoimmune disorders]] | ||
==References== | ==References== | ||
Revision as of 18:50, 30 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Common causes of waldenström's macroglobulinemia include genetic factors such as somatic mutation in MYD88 and CXCR4, environmental factors such as exposure to farming, pesticides, wood dust, and organic solvents, and immunologic factors such as chronic immune stimulation and autoimmune disorders.[1]
Causes
Genetic Causes
- Waldenström Macroglobulinemia is caused by a mutation in the MYD88 gene in 90% of cases and CXR4 in around 30% of patients.
Less Common Causes
Less common causes of waldenström's macroglobulinemia include:[1]
- Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q
- Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents
- Chronic immune stimulation and autoimmune disorders
References
- ↑ 1.0 1.1 Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9. doi:10.1038/nature09671. PMID 21179087.