Waldenström's macroglobulinemia bone marrow aspiration and biopsy: Difference between revisions
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==Overview== | ==Overview== | ||
A bone marrow aspiration may be helpful in the diagnosis of Waldenström macroglobulinemia. A bone marrow biopsy can be diagnostic of Waldenström macroglobulinemia. | A [[bone marrow aspiration]] may be helpful in the diagnosis of Waldenström macroglobulinemia. A [[bone marrow biopsy]] can be diagnostic of Waldenström macroglobulinemia. | ||
==Bone Marrow Aspirate== | ==Bone Marrow Aspirate== | ||
A bone marrow aspirate may be helpful in the diagnosis of Waldenström macroglobulinemia. | A [[Bone marrow aspiration|bone marrow aspirate]] may be helpful in the diagnosis of Waldenström macroglobulinemia. | ||
Findings suggestive of Waldenström macroglobulinemia include: | Findings suggestive of Waldenström macroglobulinemia include: | ||
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== Bone Marrow Biopsy == | == Bone Marrow Biopsy == | ||
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. | A [[bone marrow biopsy]] may be helpful in the diagnosis of Waldenström macroglobulinemia. | ||
Findings on the biopsy suggestive of Waldenström macroglobulinemia include: | Findings on the biopsy suggestive of Waldenström macroglobulinemia include: | ||
* Hypercellular and infiltrated with lymphoid and plasmacytoid cells. | * Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]]. | ||
* Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) | * Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein) | ||
Revision as of 17:36, 31 October 2018
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Waldenström's macroglobulinemia Microchapters |
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Differentiating Waldenström's macroglobulinemia from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]
Overview
A bone marrow aspiration may be helpful in the diagnosis of Waldenström macroglobulinemia. A bone marrow biopsy can be diagnostic of Waldenström macroglobulinemia.
Bone Marrow Aspirate
A bone marrow aspirate may be helpful in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:
- A hypocellular bone marrow aspirate
Bone Marrow Biopsy
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia.
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells.
- Dutcher bodies (PAS positive Intranuclear vacuoles containing IgM monoclonal protein)
- Characteristic feature of Waldenström macroglobulinemia.
Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures)