Macrocytic anemia diagnostic study of choice: Difference between revisions
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==Diagnostic study of choice== | ==Diagnostic study of choice== | ||
Homocysteine and MMA levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not MMA is increased in folate deficiency. | Homocysteine and MMA levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not MMA is increased in folate deficiency. <ref name="pmid19202968">{{cite journal |vauthors=Kaferle J, Strzoda CE |title=Evaluation of macrocytosis |journal=Am Fam Physician |volume=79 |issue=3 |pages=203–8 |date=February 2009 |pmid=19202968 |doi= |url=}}</ref><ref name="pmid23423840">{{cite journal |vauthors=Oberley MJ, Yang DT |title=Laboratory testing for cobalamin deficiency in megaloblastic anemia |journal=Am. J. Hematol. |volume=88 |issue=6 |pages=522–6 |date=June 2013 |pmid=23423840 |doi=10.1002/ajh.23421 |url=}}</ref><ref name="pmid23301732">{{cite journal |vauthors=Stabler SP |title=Clinical practice. Vitamin B12 deficiency |journal=N. Engl. J. Med. |volume=368 |issue=2 |pages=149–60 |date=January 2013 |pmid=23301732 |doi=10.1056/NEJMcp1113996 |url=}}</ref><ref name="pmid19202968">{{cite journal |vauthors=Kaferle J, Strzoda CE |title=Evaluation of macrocytosis |journal=Am Fam Physician |volume=79 |issue=3 |pages=203–8 |date=February 2009 |pmid=19202968 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
Overview
Homocysteine and MMA levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not MMA is increased in folate deficiency.
Diagnostic study of choice
Homocysteine and MMA levels can be helpful in confirmation. Both serum homocysteine and methylmalonic acid (MMA) levels are increased in helpful confirmatory tests for cobalamin and folate deficiencies. Homocysteine but not MMA is increased in folate deficiency. [1][2][3][1]
References
- ↑ 1.0 1.1 Kaferle J, Strzoda CE (February 2009). "Evaluation of macrocytosis". Am Fam Physician. 79 (3): 203–8. PMID 19202968.
- ↑ Oberley MJ, Yang DT (June 2013). "Laboratory testing for cobalamin deficiency in megaloblastic anemia". Am. J. Hematol. 88 (6): 522–6. doi:10.1002/ajh.23421. PMID 23423840.
- ↑ Stabler SP (January 2013). "Clinical practice. Vitamin B12 deficiency". N. Engl. J. Med. 368 (2): 149–60. doi:10.1056/NEJMcp1113996. PMID 23301732.