Macrocytic anemia history and symptoms: Difference between revisions
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==Overview== | ==Overview== | ||
==History and Symptoms== | ==History and Symptoms== | ||
The following points should be noted in history: | The following points should be noted in history:<ref name="pmid17972890">{{cite journal |vauthors=Christensen RD, Jopling J, Henry E, Wiedmeier SE |title=The erythrocyte indices of neonates, defined using data from over 12,000 patients in a multihospital health care system |journal=J Perinatol |volume=28 |issue=1 |pages=24–8 |date=January 2008 |pmid=17972890 |doi=10.1038/sj.jp.7211852 |url=}}</ref><ref name="pmid758417">{{cite journal |vauthors=Dallman PR, Siimes MA |title=Percentile curves for hemoglobin and red cell volume in infancy and childhood |journal=J. Pediatr. |volume=94 |issue=1 |pages=26–31 |date=January 1979 |pmid=758417 |doi= |url=}}</ref><ref name="pmid1534402">{{cite journal |vauthors=Pappo AS, Fields BW, Buchanan GR |title=Etiology of red blood cell macrocytosis during childhood: impact of new diseases and therapies |journal=Pediatrics |volume=89 |issue=6 Pt 1 |pages=1063–7 |date=June 1992 |pmid=1534402 |doi= |url=}}</ref> | ||
* Patient age: MCV is higher in neonates and infants. | * Patient age: MCV is higher in neonates and infants. | ||
* Medical history | * Medical history | ||
| Line 16: | Line 16: | ||
* Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS) | * Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS) | ||
* Macrocytosis is a common feature of MDS, especially in older adults | * Macrocytosis is a common feature of MDS, especially in older adults | ||
Patients usally show the following symptoms: | Patients usally show the following symptoms:<ref name="pmid8546042">{{cite journal |vauthors=Davenport J |title=Macrocytic anemia |journal=Am Fam Physician |volume=53 |issue=1 |pages=155–62 |date=January 1996 |pmid=8546042 |doi= |url=}}</ref><ref name="pmid7669657">{{cite journal |vauthors=Anttila P, Ihalainen J, Salo A, Heiskanen M, Juvonen E, Palotie A |title=Idiopathic macrocytic anaemia in the aged: molecular and cytogenetic findings |journal=Br. J. Haematol. |volume=90 |issue=4 |pages=797–803 |date=August 1995 |pmid=7669657 |doi= |url=}}</ref> | ||
* B12 deficiency causes neurologic dysfunction. | * B12 deficiency causes neurologic dysfunction. | ||
* Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur | * Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History and Symptoms
The following points should be noted in history:[1][2][3]
- Patient age: MCV is higher in neonates and infants.
- Medical history
- Alcohol use
- Medications (eg, anticonvulsants, zidovudine, immunosuppressive agents) – 51 (35 percent)
- Congenital heart disease – 20 (14 percent)
- Down syndrome – 12 (8 percent)
- Reticulocytosis – 11 (8 percent)
- Bone marrow failure/dysplasia – 6 (4 percent)
- Liver disease, thyroid disease [21,47]
- Hemolytic anemias with reticulocytosis and myelodysplastic syndromes (MDS)
- Macrocytosis is a common feature of MDS, especially in older adults
Patients usally show the following symptoms:[4][5]
- B12 deficiency causes neurologic dysfunction.
- Anemia symptoms such as fatigue, dyspnea, lightheadedess, and anorexia occur
- High output cardiac failure
- Angina
- Diarrhea
- Cheilosis
- Glossitis
- Subacute combined degeneration of the dorsal columns.
- Broad based gait
- Ataxic
- Numbness or paresthesias.
- Rhomberg and Babinski’s sign.
- Dementia may progress to frank “Megaloblastic Madness”
References
- ↑ Christensen RD, Jopling J, Henry E, Wiedmeier SE (January 2008). "The erythrocyte indices of neonates, defined using data from over 12,000 patients in a multihospital health care system". J Perinatol. 28 (1): 24–8. doi:10.1038/sj.jp.7211852. PMID 17972890.
- ↑ Dallman PR, Siimes MA (January 1979). "Percentile curves for hemoglobin and red cell volume in infancy and childhood". J. Pediatr. 94 (1): 26–31. PMID 758417.
- ↑ Pappo AS, Fields BW, Buchanan GR (June 1992). "Etiology of red blood cell macrocytosis during childhood: impact of new diseases and therapies". Pediatrics. 89 (6 Pt 1): 1063–7. PMID 1534402.
- ↑ Davenport J (January 1996). "Macrocytic anemia". Am Fam Physician. 53 (1): 155–62. PMID 8546042.
- ↑ Anttila P, Ihalainen J, Salo A, Heiskanen M, Juvonen E, Palotie A (August 1995). "Idiopathic macrocytic anaemia in the aged: molecular and cytogenetic findings". Br. J. Haematol. 90 (4): 797–803. PMID 7669657.