Macrocytic anemia historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal. Increase in bone marrow cellls was noted by Cohnheim in 1876 | [[Megaloblastic anemia]] and [[pernicious anemia]] was first discovered by Osler and Gardner in 1877 at Montreal. Increase in bone marrow cellls was noted by Cohnheim in 1876. | ||
==Historical Perspective== | ==Historical Perspective== | ||
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===Discovery=== | ===Discovery=== | ||
Following facts were found in historical perspective:<ref name="pmid11122079">{{cite journal |vauthors=Chanarin I |title=Historical review: a history of pernicious anaemia |journal=Br. J. Haematol. |volume=111 |issue=2 |pages=407–15 |date=November 2000 |pmid=11122079 |doi= |url=}}</ref> | Following facts were found in historical perspective:<ref name="pmid11122079">{{cite journal |vauthors=Chanarin I |title=Historical review: a history of pernicious anaemia |journal=Br. J. Haematol. |volume=111 |issue=2 |pages=407–15 |date=November 2000 |pmid=11122079 |doi= |url=}}</ref> | ||
*Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal. | *[[Megaloblastic anemia]] and [[pernicious anemia]] was first discovered by Osler and Gardner in 1877 at Montreal. | ||
*Increase in bone marrow | *Increase in [[bone marrow cells]] was noted by Cohnheim in 1876. | ||
*The association between megaloblastic(pernicious) anemia and spinal cord lesions was made in 1887 by Lichtheim. | *The association between [[Megaloblastic anemia|megaloblastic]]([[Pernicious anemia|pernicious]]) [[anemia]] and [[spinal cord]] lesions was made in 1887 by Lichtheim. | ||
*[[Subacute combined degeneration of spinal cord]] was coined by Russell et al in 1900. | *[[Subacute combined degeneration of spinal cord]] was coined by Russell et al in 1900. | ||
*In 1908, Cabot was the first to discover the association between | *In 1908, Cabot was the first to discover the association between [[megaloblastic anemia]] and the development of [[numbness]] and [[tingling]] of extremities. | ||
*In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and [[hemoglobin]] levels. | *In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like [[liver]], [[muscle]] meat, leafy [[vegetables]], eggs and milk. they discovered rises in [[cell]] count and [[hemoglobin]] levels. | ||
*In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures. | *In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for [[medicine]] and [[physiology]] for saving the lives of [[anemic]] people with [[dietary]] measures. | ||
==References== | ==References== | ||
Revision as of 20:54, 6 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2] Omer Kamal, M.D.[3]
Overview
Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal. Increase in bone marrow cellls was noted by Cohnheim in 1876.
Historical Perspective
Discovery
Following facts were found in historical perspective:[1]
- Megaloblastic anemia and pernicious anemia was first discovered by Osler and Gardner in 1877 at Montreal.
- Increase in bone marrow cells was noted by Cohnheim in 1876.
- The association between megaloblastic(pernicious) anemia and spinal cord lesions was made in 1887 by Lichtheim.
- Subacute combined degeneration of spinal cord was coined by Russell et al in 1900.
- In 1908, Cabot was the first to discover the association between megaloblastic anemia and the development of numbness and tingling of extremities.
- In 1923, Minot and Murphy started a diet for people with anemia which had animal sources like liver, muscle meat, leafy vegetables, eggs and milk. they discovered rises in cell count and hemoglobin levels.
- In 1934, Whipple, Minot and Murphy were awarded with Nobel prize for medicine and physiology for saving the lives of anemic people with dietary measures.