Myelofibrosis differential diagnosis: Difference between revisions

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Revision as of 18:05, 14 November 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]

Overview

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, splenomegaly, anemia, leukopenia, thrombocytopenia, leukocytosis, thrombocytosis, and extramedullary hematopoiesis such as sickle cell disease, hyperthyroidism, sclerosing bone dysplasia, osteoblastic metastases, Paget's disease, acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), polycythemia vera, myelodysplastic syndrome, chronic myelomonocytic leukemia, acute panmyelosis, acute megakaryoblastic leukemia, cirrhosis, infections, neoplastic and lipid storage disorders.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Differentiating Myelofibrosis from other Diseases

Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, anemia, leukopenia, thrombocytopenia, leukocytosis, or thrombocytosis. They are presented in the table below.^[2]^[3]^[4]^[6]^[7]


Type of diseases	Diseases

Hematological	Sickle cell disease
Metabolic bone disorders	Hyperthyroidism Hypoparathyroidism Renal osteodystrophy
Congenital	Sclerosing bone dysplasia Osteopetrosis Pyknodysostosis
Malignancy	Lymphoma: infiltration Leukaemia: infiltration Osteoblastic metastases from: prostate cancer breast cancer
Other	Paget disease Fluorosis Mastocytosis Hepatitis C associated osteosclerosis

Myelofibrosis must also be differentiated from other diseases that cause splenomegaly and/or extramedullary hematopoiesis. They are presented in the table below.^[1]^[5]^[6]


Type of diseases	Diseases

Hematological causes	Anemia Sickle cell disease Thalassemia Hereditary spherocytosis Pyruvate kinase deficiency Thrombotic thrombocytopenic purpura (TTP) Neoplastic/proliferative/redistribution of hematopoesis Leukemia (especially CML) Polycythemia rubra vera (PRV) Waldenstorm macroglobulinemia Osteopetrosis Idiopathic hypereosinophilic syndrome _{* = may cause massive splenomegaly}
Hemodynamic	Portal hypertension in the setting of cirrhosis Congestive splenomegaly (Banti's syndrome) Splenic vein obstruction Portal vein obstruction Right heart failure
Infections	Viral Infectious mononucleosis AIDS CMV Herpes simplex virus Rubella Bacterial Tuberculosis (miliary) Tularemia Subacute bacterial endocarditis Typhoid fever Brucellosis Syphilis Abscess Fungal Histoplasmosis (common) Candidiasis Parasitic disease Malaria* Schistosomiasis Hydatid disease Leishmaniasis (kala-azar) Rickettsial Typhus
Storage diseases/metabolic/infiltrative disorders	Gaucher disease Glycogen storage disease Mucopolysaccharidoses Niemann-Pick disease Hemochromatosis Amyloidosis Porphyria Sarcoidosis
Neoplastic	Lymphoma (common) Metastases (breast, lung, colon, ovary, melanoma) Hemangioma Lymphangioma Angiosarcoma
Trauma	Hematoma Pseudocyst
Connective tissue disorders	Systemic lupus erythematosus (SLE) Rheumatoid arthritis Felty's syndrome Juvenile rheumatoid arthritis (JRA) Still's disease

References

↑ ^1.0 ^1.1 Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/Italic textarticles/splenomegaly. Accessed on March 11, 2016
↑ ^2.0 ^2.1 Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ (December 2013). "Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis". Int J Lab Hematol. 35 (6): 629–36. doi:10.1111/ijlh.12101. PMID 23693053.
↑ ^3.0 ^3.1 Tefferi A (September 2014). "Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 89 (9): 915–25. doi:10.1002/ajh.23703. PMID 25124313.
↑ ^4.0 ^4.1 Tefferi A (February 2013). "Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 88 (2): 141–50. doi:10.1002/ajh.23384. PMID 23349007.
↑ ^5.0 ^5.1 Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL (November 2013). "[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis]". Pathologe (in German). 34 Suppl 2: 201–9. doi:10.1007/s00292-013-1824-8. PMID 24196613.
↑ ^6.0 ^6.1 ^6.2 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
↑ ^7.0 ^7.1 Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016

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[splenomegalydiffdiagnosisradio1-1] 1.0 ^1.1 Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/Italic textarticles/splenomegaly. Accessed on March 11, 2016

[pmid23693053-2] 2.0 ^2.1 Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ (December 2013). "Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis". Int J Lab Hematol. 35 (6): 629–36. doi:10.1111/ijlh.12101. PMID 23693053.

[pmid25124313-3] 3.0 ^3.1 Tefferi A (September 2014). "Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 89 (9): 915–25. doi:10.1002/ajh.23703. PMID 25124313.

[pmid23349007-4] 4.0 ^4.1 Tefferi A (February 2013). "Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 88 (2): 141–50. doi:10.1002/ajh.23384. PMID 23349007.

[pmid24196613-5] 5.0 ^5.1 Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL (November 2013). "[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis]". Pathologe (in German). 34 Suppl 2: 201–9. doi:10.1007/s00292-013-1824-8. PMID 24196613.

[myelofibrosisdiffdiagnsosiseradio1-6] 6.0 ^6.1 ^6.2 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016

[Diffusebonysclerosisdifferentialdiagnosis1-7] 7.0 ^7.1 Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016

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@@ Line 71: / Line 71: @@
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Hemodynamic
-| style="padding: 5px 5px; background: #F5F5F5;" |[[Cirrhosis]]: [[portal hypertension]]<br>[[Banti's syndrome|Congestive splenomegaly (Banti's syndrome)]]<br>[[splenic vein|Splenic vein obstruction]]<br>[[portal vein|Portal vein obstruction]]<br>[[Right heart failure]]
+| style="padding: 5px 5px; background: #F5F5F5;" |
+*[[Portal hypertension]] in the setting of [[cirrhosis]]
+*[[Banti's syndrome|Congestive splenomegaly (Banti's syndrome)]]
+*[[splenic vein|Splenic vein]] [[obstruction]]
+*[[portal vein|Portal vein]] [[obstruction]]
+*[[Right heart failure]]
 |-
-| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Infection
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Infections
 | style="padding: 5px 5px; background: #F5F5F5;" |'''Viral'''
-*[[EBV]] (infectious mononucleosis) - (common)
+*[[Infectious mononucleosis]]
 *[[AIDS]]
 *[[CMV]]

Myelofibrosis differential diagnosis: Difference between revisions

Revision as of 18:05, 14 November 2018

Overview

Differentiating Myelofibrosis from other Diseases

References

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