Hairy cell leukemia diagnotic study of choice: Difference between revisions
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[[Peripheral blood smear|Peripheral blood smears]] is one of the gold standard test for the diagnosis of [[hairy cell leukemia]]. | [[Peripheral blood smear|Peripheral blood smears]] is one of the gold standard test for the diagnosis of [[hairy cell leukemia]]. | ||
The following result of [[Peripheral blood smear|peripheral blood smears]] is confirmatory of [[hairy cell leukemia]]:<ref name=" | The following result of [[Peripheral blood smear|peripheral blood smears]] is confirmatory of [[hairy cell leukemia]]:<ref name="GreverAbdel-Wahab2017">{{cite journal|last1=Grever|first1=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|last10=Demeter|first10=Judit|last11=Else|first11=Monica|last12=Forconi|first12=Francesco|last13=Gozzetti|first13=Alessandro|last14=Ho|first14=Anthony D.|last15=Johnston|first15=James B.|last16=Jones|first16=Jeffrey|last17=Juliusson|first17=Gunnar|last18=Kraut|first18=Eric|last19=Kreitman|first19=Robert J.|last20=Larratt|first20=Loree|last21=Lauria|first21=Francesco|last22=Lozanski|first22=Gerard|last23=Montserrat|first23=Emili|last24=Parikh|first24=Sameer A.|last25=Park|first25=Jae H.|last26=Polliack|first26=Aaron|last27=Quest|first27=Graeme R.|last28=Rai|first28=Kanti R.|last29=Ravandi|first29=Farhad|last30=Robak|first30=Tadeusz|last31=Saven|first31=Alan|last32=Seymour|first32=John F.|last33=Tadmor|first33=Tamar|last34=Tallman|first34=Martin S.|last35=Tam|first35=Constantine|last36=Tiacci|first36=Enrico|last37=Troussard|first37=Xavier|last38=Zent|first38=Clive S.|last39=Zenz|first39=Thorsten|last40=Zinzani|first40=Pier Luigi|last41=Falini|first41=Brunangelo|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|journal=Blood|volume=129|issue=5|year=2017|pages=553–560|issn=0006-4971|doi=10.1182/blood-2016-01-689422}}</ref> | ||
* Oval [[nuclei]] and abundant [[cytoplasm]] with "hairy" projections | * Oval [[nuclei]] and abundant [[cytoplasm]] with "hairy" projections | ||
* Fried egg appearance | * Fried egg appearance | ||
Revision as of 17:28, 20 November 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Peripheral blood smears are the gold standard test for the diagnosis of hairy cell leukemia.
Diagnostic Study of Choice
Study of choice
Peripheral blood smear:
Peripheral blood smears is one of the gold standard test for the diagnosis of hairy cell leukemia.
The following result of peripheral blood smears is confirmatory of hairy cell leukemia:[1]
- Oval nuclei and abundant cytoplasm with "hairy" projections
- Fried egg appearance
- Loose chromatin
- Mast cells numbers elevation
- Extravasated red cells are positive in peripheral blood smear of hairy cell leukemia patients
References
- ↑ Grever, Michael R.; Abdel-Wahab, Omar; Andritsos, Leslie A.; Banerji, Versha; Barrientos, Jacqueline; Blachly, James S.; Call, Timothy G.; Catovsky, Daniel; Dearden, Claire; Demeter, Judit; Else, Monica; Forconi, Francesco; Gozzetti, Alessandro; Ho, Anthony D.; Johnston, James B.; Jones, Jeffrey; Juliusson, Gunnar; Kraut, Eric; Kreitman, Robert J.; Larratt, Loree; Lauria, Francesco; Lozanski, Gerard; Montserrat, Emili; Parikh, Sameer A.; Park, Jae H.; Polliack, Aaron; Quest, Graeme R.; Rai, Kanti R.; Ravandi, Farhad; Robak, Tadeusz; Saven, Alan; Seymour, John F.; Tadmor, Tamar; Tallman, Martin S.; Tam, Constantine; Tiacci, Enrico; Troussard, Xavier; Zent, Clive S.; Zenz, Thorsten; Zinzani, Pier Luigi; Falini, Brunangelo (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971.