Parkinson's disease MRI: Difference between revisions
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==MRI== | ==MRI== | ||
Diagnosis of Parkinson disease is mostly clinical but there are some [[Magnetic resonance imaging|MRI]] finding supporting the diagnosis. In the [[STN]] of [[Parkinson's disease|PD]] patients there are increased amount of [[iron]]. The excess iron will cause a reduction in T2 relaxation time and it’s more prominent in one side.<ref name="pmid15981079">{{cite journal |vauthors=Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S |title=MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease |journal=J. Neurol. |volume=253 |issue=1 |pages=26–32 |date=January 2006 |pmid=15981079 |doi=10.1007/s00415-005-0914-9 |url=}}</ref> There are also evidence of reduced [[iron]] content in [[putamen]] and [[Globus pallidus|GPe]].<ref name="pmid11099445">{{cite journal |vauthors=Graham JM, Paley MN, Grünewald RA, Hoggard N, Griffiths PD |title=Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence |journal=Brain |volume=123 Pt 12 |issue= |pages=2423–31 |date=December 2000 |pmid=11099445 |doi= |url=}}</ref><ref name="pmid7763206">{{cite journal |vauthors=Ryvlin P, Broussolle E, Piollet H, Viallet F, Khalfallah Y, Chazot G |title=Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease |journal=Arch. Neurol. |volume=52 |issue=6 |pages=583–8 |date=June 1995 |pmid=7763206 |doi= |url=}}</ref> | * Diagnosis of Parkinson disease is mostly clinical but there are some [[Magnetic resonance imaging|MRI]] finding supporting the diagnosis. | ||
* In the [[STN]] of [[Parkinson's disease|PD]] patients there are increased amount of [[iron]]. The excess iron will cause a reduction in T2 relaxation time and it’s more prominent in one side.<ref name="pmid15981079">{{cite journal |vauthors=Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S |title=MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease |journal=J. Neurol. |volume=253 |issue=1 |pages=26–32 |date=January 2006 |pmid=15981079 |doi=10.1007/s00415-005-0914-9 |url=}}</ref> There are also evidence of reduced [[iron]] content in [[putamen]] and [[Globus pallidus|GPe]].<ref name="pmid11099445">{{cite journal |vauthors=Graham JM, Paley MN, Grünewald RA, Hoggard N, Griffiths PD |title=Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence |journal=Brain |volume=123 Pt 12 |issue= |pages=2423–31 |date=December 2000 |pmid=11099445 |doi= |url=}}</ref><ref name="pmid7763206">{{cite journal |vauthors=Ryvlin P, Broussolle E, Piollet H, Viallet F, Khalfallah Y, Chazot G |title=Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease |journal=Arch. Neurol. |volume=52 |issue=6 |pages=583–8 |date=June 1995 |pmid=7763206 |doi= |url=}}</ref> | |||
* We can also use [[MRI]] to differentiate [[Parkinson's disease|PD]] from other conditions. for example in the [[midbrain]], thinning of anteroposterior diameter and enlargement of [[third ventricle]] in suggestive of supranuclear palsy.<ref name="pmid2812334">{{cite journal |vauthors=Stern MB, Braffman BH, Skolnick BE, Hurtig HI, Grossman RI |title=Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes |journal=Neurology |volume=39 |issue=11 |pages=1524–6 |date=November 1989 |pmid=2812334 |doi= |url=}}</ref><ref name="pmid11458995">{{cite journal |vauthors=Asato R, Akiguchi I, Masunaga S, Hashimoto N |title=Magnetic resonance imaging distinguishes progressive supranuclear palsy from multiple system atrophy |journal=J Neural Transm (Vienna) |volume=107 |issue=12 |pages=1427–36 |date=2000 |pmid=11458995 |doi=10.1007/s007020070006 |url=}}</ref> | |||
* Also we can see atrophy of [[Brain stem|brainstem]] and [[cerebellum]] in [[multiple system atrophy]].<ref name="pmid7798985">{{cite journal |vauthors=Konagaya M, Konagaya Y, Iida M |title=Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy |journal=J. Neurol. Neurosurg. Psychiatry |volume=57 |issue=12 |pages=1528–31 |date=December 1994 |pmid=7798985 |pmc=1073237 |doi= |url=}}</ref><ref name="pmid12589575">{{cite journal |vauthors=Yekhlef F, Ballan G, Macia F, Delmer O, Sourgen C, Tison F |title=Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD |journal=J Neural Transm (Vienna) |volume=110 |issue=2 |pages=151–69 |date=February 2003 |pmid=12589575 |doi=10.1007/s00702-002-0785-5 |url=}}</ref> | |||
==References== | ==References== | ||
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Overview
MRI
- Diagnosis of Parkinson disease is mostly clinical but there are some MRI finding supporting the diagnosis.
- In the STN of PD patients there are increased amount of iron. The excess iron will cause a reduction in T2 relaxation time and it’s more prominent in one side.[1] There are also evidence of reduced iron content in putamen and GPe.[2][3]
- We can also use MRI to differentiate PD from other conditions. for example in the midbrain, thinning of anteroposterior diameter and enlargement of third ventricle in suggestive of supranuclear palsy.[4][5]
- Also we can see atrophy of brainstem and cerebellum in multiple system atrophy.[6][7]
References
- ↑ Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S (January 2006). "MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease". J. Neurol. 253 (1): 26–32. doi:10.1007/s00415-005-0914-9. PMID 15981079.
- ↑ Graham JM, Paley MN, Grünewald RA, Hoggard N, Griffiths PD (December 2000). "Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence". Brain. 123 Pt 12: 2423–31. PMID 11099445.
- ↑ Ryvlin P, Broussolle E, Piollet H, Viallet F, Khalfallah Y, Chazot G (June 1995). "Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease". Arch. Neurol. 52 (6): 583–8. PMID 7763206.
- ↑ Stern MB, Braffman BH, Skolnick BE, Hurtig HI, Grossman RI (November 1989). "Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes". Neurology. 39 (11): 1524–6. PMID 2812334.
- ↑ Asato R, Akiguchi I, Masunaga S, Hashimoto N (2000). "Magnetic resonance imaging distinguishes progressive supranuclear palsy from multiple system atrophy". J Neural Transm (Vienna). 107 (12): 1427–36. doi:10.1007/s007020070006. PMID 11458995.
- ↑ Konagaya M, Konagaya Y, Iida M (December 1994). "Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy". J. Neurol. Neurosurg. Psychiatry. 57 (12): 1528–31. PMC 1073237. PMID 7798985.
- ↑ Yekhlef F, Ballan G, Macia F, Delmer O, Sourgen C, Tison F (February 2003). "Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD". J Neural Transm (Vienna). 110 (2): 151–69. doi:10.1007/s00702-002-0785-5. PMID 12589575.