Myelofibrosis diagnostic study of choice: Difference between revisions
Created page with "__NOTOC__ {{Myelofibrosis}} {{CMG}}{{AE}}{{SR}} ==Overview== Diagnosis of myelofibrosis may be made based upon a thorough clinical evaluation, detailed patient history, and s..." |
|||
| Line 7: | Line 7: | ||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
===2001 WHO criteria for prefibrotic/early (pre-primary myelofibrosis) phase=== | |||
====Clinical findings==== | |||
*Spleen and liver | |||
:*No or mild splenomegaly or hepatomegaly | |||
*Hematology (variable) | |||
:*Mild anemia | |||
:*Mild to moderate leukocytosis | |||
:*Mild to marked thrombocytosis | |||
====Morphological findings==== | |||
*Blood | |||
:*No or mild leukoerythroblastosis | |||
:*No or mild red blood cell poikilocytosis | |||
:*Few if any dacryocytes | |||
*Bone marrow | |||
:*Hypercellularity | |||
:*Neutrophilic proliferation | |||
:*Megakaryocytic proliferation | |||
According to the World Health Organization (WHO) diagnostic criteria for primary myelofibrosis, [[polycythemia vera]], and [[essential thrombocythemia]], the diagnosis of primary myelofibrosis is made when all three of the following major diagnostic criteria and at least two minor criteria are met.<ref name=diagnosticcriteriamyelofibrosis1>World Health Organization (WHO) Diagnostic Criteria for Primary Myelofibrosis (PMF), Polycythemia Vera (PV), and Essential Thrombocythemia (ET). MPN Connect 2016. http://www.mpnconnect.com/pdf/who-diagnostic-criteria-myelofibrosis.pdf. Accessed on March 8, 2016</ref><ref name="pmid17488875">{{cite journal| author=Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA et al.| title=Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. | journal=Blood | year= 2007 | volume= 110 | issue= 4 | pages= 1092-7 | pmid=17488875 | doi=10.1182/blood-2007-04-083501 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17488875 }} </ref> | According to the World Health Organization (WHO) diagnostic criteria for primary myelofibrosis, [[polycythemia vera]], and [[essential thrombocythemia]], the diagnosis of primary myelofibrosis is made when all three of the following major diagnostic criteria and at least two minor criteria are met.<ref name=diagnosticcriteriamyelofibrosis1>World Health Organization (WHO) Diagnostic Criteria for Primary Myelofibrosis (PMF), Polycythemia Vera (PV), and Essential Thrombocythemia (ET). MPN Connect 2016. http://www.mpnconnect.com/pdf/who-diagnostic-criteria-myelofibrosis.pdf. Accessed on March 8, 2016</ref><ref name="pmid17488875">{{cite journal| author=Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA et al.| title=Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. | journal=Blood | year= 2007 | volume= 110 | issue= 4 | pages= 1092-7 | pmid=17488875 | doi=10.1182/blood-2007-04-083501 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17488875 }} </ref> | ||
Revision as of 20:35, 30 November 2018
|
Myelofibrosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Myelofibrosis diagnostic study of choice On the Web |
|
American Roentgen Ray Society Images of Myelofibrosis diagnostic study of choice |
|
Risk calculators and risk factors for Myelofibrosis diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Diagnosis of myelofibrosis may be made based upon a thorough clinical evaluation, detailed patient history, and specialized tests. The World Health Organization (WHO) has set the criteria for diagnosing primary myelofibrosis (PMF). It has determined set rules for distinguishing the prefibrotic/early (pre-primary myelofibrosis) phase and the overtly fibrotic (overt primary myelofibrosis) phase. The World Health Organization (WHO) has also introduced a proposed revised criteria for primary myelofibrosis (PMF).
Diagnostic Criteria
2001 WHO criteria for prefibrotic/early (pre-primary myelofibrosis) phase
Clinical findings
- Spleen and liver
- No or mild splenomegaly or hepatomegaly
- Hematology (variable)
- Mild anemia
- Mild to moderate leukocytosis
- Mild to marked thrombocytosis
Morphological findings
- Blood
- No or mild leukoerythroblastosis
- No or mild red blood cell poikilocytosis
- Few if any dacryocytes
- Bone marrow
- Hypercellularity
- Neutrophilic proliferation
- Megakaryocytic proliferation
According to the World Health Organization (WHO) diagnostic criteria for primary myelofibrosis, polycythemia vera, and essential thrombocythemia, the diagnosis of primary myelofibrosis is made when all three of the following major diagnostic criteria and at least two minor criteria are met.[1][2]
| Major Criteria | Minor Criteria |
|---|---|
|
I. On bone marrow biopsy, proliferation and atypia of megakaryocytes, with or without reticulin or collagen fibrosis and it must be accompanied by hypercellular bone marrow |
I. Anemia |
References
- ↑ World Health Organization (WHO) Diagnostic Criteria for Primary Myelofibrosis (PMF), Polycythemia Vera (PV), and Essential Thrombocythemia (ET). MPN Connect 2016. http://www.mpnconnect.com/pdf/who-diagnostic-criteria-myelofibrosis.pdf. Accessed on March 8, 2016
- ↑ Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA; et al. (2007). "Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel". Blood. 110 (4): 1092–7. doi:10.1182/blood-2007-04-083501. PMID 17488875.