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==Classification==
==Classification==
'''Classification of [[breast lumps]] based on [[epithelial hyperplasia]]<ref name="pmid16034008">{{cite journal| author=Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K et al.| title=Benign breast disease and the risk of breast cancer. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 3 | pages= 229-37 | pmid=16034008 | doi=10.1056/NEJMoa044383 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16034008  }} </ref>'''
'''Classification of [[breast lumps]] based on [[epithelial hyperplasia]]<ref name="pmid16034008">{{cite journal| author=Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K et al.| title=Benign breast disease and the risk of breast cancer. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 3 | pages= 229-37 | pmid=16034008 | doi=10.1056/NEJMoa044383 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16034008  }} </ref>'''
*Approximately 65% of all [[BBD]] considered as [[nonproliferative]](NP)with relative cancer risk of 1.2, 1.4 times:
*Approximately 65% of all BBD considered as [[nonproliferative]](NP)with relative cancer risk of 1.2, 1.4 times:
**Simple cyst
**Simple cyst
**Fibrosis
**Fibrosis
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** Apocrine metaplasia (simple)
** Apocrine metaplasia (simple)
** Mild ductal hyperplasia  
** Mild ductal hyperplasia  
* Approximately 30% of total are classifed as [[proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
* Approximately 30% of total are classifed as [[proliferative disease]](PD) with relative cancer risk of 1.7, 2.1 times
** Usual ductal hyperplasia
** Usual ductal hyperplasia
**  Sclerosing adenosis
**  Sclerosing adenosis
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** papilloma
** papilloma
** Radical scar
** Radical scar
* Approximately 5% to 8% of the rest regarded to [[PD with atypia]]with relative cancer risk more than 4 times
* Approximately 5% to 8% of the rest regarded to [[PD with atypia]] with relative cancer risk more than 4 times
** Atypical lobar hyperplasia
** Atypical lobar hyperplasia
** Lobular carcinoma in situ
** Lobular carcinoma in situ

Revision as of 16:23, 6 December 2018


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

Classification

Classification of breast lumps based on epithelial hyperplasia[1]

  • Approximately 65% of all BBD considered as nonproliferative(NP)with relative cancer risk of 1.2, 1.4 times:
    • Simple cyst
    • Fibrosis
    • Fibroadenoma (simple)
    • Columnar alteration (Simple)
    • Apocrine metaplasia (simple)
    • Mild ductal hyperplasia
  • Approximately 30% of total are classifed as proliferative disease(PD) with relative cancer risk of 1.7, 2.1 times
    • Usual ductal hyperplasia
    • Sclerosing adenosis
    • Columnar hyperplasia
    • papilloma
    • Radical scar
  • Approximately 5% to 8% of the rest regarded to PD with atypia with relative cancer risk more than 4 times
    • Atypical lobar hyperplasia
    • Lobular carcinoma in situ
    • Atypical ductal hyperplasia
  • Unclear risk
    • Mucocele like tumor
    • Apocrine atypia
    • Secretory atypia

References

  1. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.