Breast lumps risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
Associated risk factors leading to female [[breast cancer]]<ref name="pmid25114845">{{cite journal| author=Shah R, Rosso K, Nathanson SD| title=Pathogenesis, prevention, diagnosis and treatment of breast cancer. | journal=World J Clin Oncol | year= 2014 | volume= 5 | issue= 3 | pages= 283-98 | pmid=25114845 | doi=10.5306/wjco.v5.i3.283 | pmc=4127601 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25114845 }} </ref> | Associated risk factors leading to [[female]] [[breast cancer]]<ref name="pmid25114845">{{cite journal| author=Shah R, Rosso K, Nathanson SD| title=Pathogenesis, prevention, diagnosis and treatment of breast cancer. | journal=World J Clin Oncol | year= 2014 | volume= 5 | issue= 3 | pages= 283-98 | pmid=25114845 | doi=10.5306/wjco.v5.i3.283 | pmc=4127601 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25114845 }} </ref> | ||
* Age: probability of breast | * [[Age]]: probability of [[Breast cancer|breast cance]]<nowiki/>r from birth to 39 years; 1 in 202, from 40 to 59 years; 1 in 26, from 60 to 69 years; 1 in 28. | ||
*Personal history of breast cancer | *Personal history of [[breast cancer]] | ||
*Breast pathology: PD with atypia has greater risk of developing to breast cancer in comparison of PD. | *Breast [[pathology]]: PD with [[atypia]] has greater risk of developing to [[breast cancer]] in comparison of PD. | ||
*Family history: greater breast cancer risk in women with first degree relatives with breast cancer under 50 years old. | *[[Family history]]: greater [[breast cancer]] risk in women with first-degree relatives with [[breast cancer]] under 50 years old. | ||
*Genetic predisposition | *[[Genetic]] predisposition | ||
**High risk | **High risk | ||
*** BRCA1 | *** [[BRCA1]] | ||
***BRCA2 | ***[[BRCA2]] | ||
**Moderate risk | **Moderate risk | ||
*** Homozygous ataxia-telangiectasia (ATM) | *** [[Homozygous]] [[ataxia-telangiectasia]] (ATM) | ||
*** Somatic mutation in CHEK2 | *** Somatic mutation in [[CHEK2]] | ||
***BRCA1 modifier gene: BRIP1 | ***[[BRCA1]] modifier gene: [[BRIP1]] | ||
***BRCA2 modifier gene: PALB2 | ***[[BRCA2]] modifier gene: [[PALB2]] | ||
** Low risk | ** Low risk | ||
***These alleles have not designated yet. | ***These [[alleles]] have not designated yet. | ||
[[Endogenous hormone exposure and reproductive factors]] | [[Endogenous hormone exposure and reproductive factors]] | ||
* Early menarche;under age of 13 years | * Early [[menarche]]; under age of 13 years | ||
*Parity; nulliparous is associated with | *[[Parity]]; [[nulliparous]] is associated with increased risk of [[breast cancer]] | ||
*Age at first full term pregnancy; younger age may decrease risk of breast cancer | *Age at first [[full term]] [[pregnancy]]; younger age may decrease risk of [[breast cancer]] | ||
*Breast feeding; decreased risk of breast cancer | *[[Breast feeding]]; decreased risk of [[breast cancer]] | ||
* Testostrone; increased relative risk to 2.86-3.28 | * [[Testostrone|Testosterone]]; increased [[relative risk]] to 2.86-3.28 | ||
*Age at menopause;older menopausal age associated with greater risk of breast cancer | *[[Age]] at [[menopause]];older [[menopausal]] [[age]] associated with greater risk of [[breast cancer]] | ||
[[Exogenous hormone exposure]] | [[Exogenous hormone exposure]] | ||
*long term exposure> 5 years; increases chances of breast cancer | *long term exposure> 5 years; increases chances of [[breast cancer]] | ||
*Time of usage;nearly menopausal age associated with development to breast cancer | *Time of usage; nearly [[menopausal]] [[age]] associated with development to [[breast cancer]] | ||
[[Lifestyle]] | [[Lifestyle]] | ||
These factors may increase risk of developing breast cancers | |||
* Alcohol consumption; even as 5.0 to 9.9 per day, approximately 3 to 6 drinks per week, developed with relative risk 1.15 | These factors may increase risk of developing [[Breast Cancer|breast cancers]] | ||
* [[Alcohol]] consumption; even as 5.0 to 9.9 per day, approximately 3 to 6 drinks per week, developed with [[relative risk]] 1.15 | |||
*Inactivity | *Inactivity | ||
*Obesity; BMI:25-29.9 and BMI>30 have relative risk | *[[Obesity]]; [[BMI|BM]]I: 25-29.9 and [[BMI]] >30 have [[relative risk]] of 1.28 | ||
*Previous history of radiation;at the age< | *Previous history of [[radiation]]; at the [[age]] < 35 years old | ||
==References== | ==References== | ||
Revision as of 19:40, 7 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Risk Factors
Associated risk factors leading to female breast cancer[1]
- Age: probability of breast cancer from birth to 39 years; 1 in 202, from 40 to 59 years; 1 in 26, from 60 to 69 years; 1 in 28.
- Personal history of breast cancer
- Breast pathology: PD with atypia has greater risk of developing to breast cancer in comparison of PD.
- Family history: greater breast cancer risk in women with first-degree relatives with breast cancer under 50 years old.
- Genetic predisposition
- High risk
- Moderate risk
- Homozygous ataxia-telangiectasia (ATM)
- Somatic mutation in CHEK2
- BRCA1 modifier gene: BRIP1
- BRCA2 modifier gene: PALB2
- Low risk
- These alleles have not designated yet.
Endogenous hormone exposure and reproductive factors
- Early menarche; under age of 13 years
- Parity; nulliparous is associated with increased risk of breast cancer
- Age at first full term pregnancy; younger age may decrease risk of breast cancer
- Breast feeding; decreased risk of breast cancer
- Testosterone; increased relative risk to 2.86-3.28
- Age at menopause;older menopausal age associated with greater risk of breast cancer
- long term exposure> 5 years; increases chances of breast cancer
- Time of usage; nearly menopausal age associated with development to breast cancer
These factors may increase risk of developing breast cancers
- Alcohol consumption; even as 5.0 to 9.9 per day, approximately 3 to 6 drinks per week, developed with relative risk 1.15
- Inactivity
- Obesity; BMI: 25-29.9 and BMI >30 have relative risk of 1.28
- Previous history of radiation; at the age < 35 years old
References
- ↑ Shah R, Rosso K, Nathanson SD (2014). "Pathogenesis, prevention, diagnosis and treatment of breast cancer". World J Clin Oncol. 5 (3): 283–98. doi:10.5306/wjco.v5.i3.283. PMC 4127601. PMID 25114845.