Myelofibrosis differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, splenomegaly, anemia, leukopenia, thrombocytopenia, leukocytosis, thrombocytosis, and extramedullary hematopoiesis such as [[sickle cell disease]], [[hyperthyroidism]], [[dysplasia|sclerosing bone dysplasia]], [[bone metastasis|osteoblastic metastases]], [[Paget's disease]], acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), polycythemia vera, myelodysplastic syndrome, chronic myelomonocytic leukemia, acute panmyelosis, acute megakaryoblastic leukemia, cirrhosis, infections, neoplastic and lipid storage disorders.<ref name=splenomegalydiffdiagnosisradio1>Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/''Italic text''articles/splenomegaly. Accessed on March 11, 2016</ref><ref name="pmid23693053">{{cite journal |vauthors=Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ |title=Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis |journal=Int J Lab Hematol |volume=35 |issue=6 |pages=629–36 |date=December 2013 |pmid=23693053 |doi=10.1111/ijlh.12101 |url=}}</ref><ref name="pmid25124313">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=9 |pages=915–25 |date=September 2014 |pmid=25124313 |doi=10.1002/ajh.23703 |url=}}</ref><ref name="pmid23349007">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=88 |issue=2 |pages=141–50 |date=February 2013 |pmid=23349007 |doi=10.1002/ajh.23384 |url=}}</ref><ref name="pmid24196613">{{cite journal |vauthors=Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL |title=[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis] |language=German |journal=Pathologe |volume=34 Suppl 2 |issue= |pages=201–9 |date=November 2013 |pmid=24196613 |doi=10.1007/s00292-013-1824-8 |url=}}</ref><ref name=myelofibrosisdiffdiagnsosiseradio1>Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name=Diffusebonysclerosisdifferentialdiagnosis1>Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016</ref> | [[Myelofibrosis]] must be differentiated from other [[Disease|diseases]] that cause diffuse [[bone]] [[sclerosis]], [[splenomegaly]], [[anemia]], [[leukopenia]], [[thrombocytopenia]], [[leukocytosis]], [[thrombocytosis]], and [[Extramedullary hematopoiesis|extramedullary hematopoiesis (EMH)]] such as [[sickle cell disease]], [[hyperthyroidism]], [[dysplasia|sclerosing bone dysplasia]], [[bone metastasis|osteoblastic metastases]], [[Paget's disease]], [[Acute myelogenous leukemia|acute myelogenous leukemia (AML)]], [[Chronic myelogenous leukemia|chronic myelogenous leukemia (CML)]], [[Polycythemia vera|polycythemia vera (PV)]], [[myelodysplastic syndrome]], [[chronic myelomonocytic leukemia]], acute panmyelosis, [[acute megakaryoblastic leukemia]], [[cirrhosis]], [[Infection|infections]], [[neoplastic]] and [[Lipid storage disorder|lipid storage disorders]].<ref name="splenomegalydiffdiagnosisradio1">Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/''Italic text''articles/splenomegaly. Accessed on March 11, 2016</ref><ref name="pmid23693053">{{cite journal |vauthors=Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ |title=Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis |journal=Int J Lab Hematol |volume=35 |issue=6 |pages=629–36 |date=December 2013 |pmid=23693053 |doi=10.1111/ijlh.12101 |url=}}</ref><ref name="pmid25124313">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=9 |pages=915–25 |date=September 2014 |pmid=25124313 |doi=10.1002/ajh.23703 |url=}}</ref><ref name="pmid23349007">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=88 |issue=2 |pages=141–50 |date=February 2013 |pmid=23349007 |doi=10.1002/ajh.23384 |url=}}</ref><ref name="pmid24196613">{{cite journal |vauthors=Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL |title=[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis] |language=German |journal=Pathologe |volume=34 Suppl 2 |issue= |pages=201–9 |date=November 2013 |pmid=24196613 |doi=10.1007/s00292-013-1824-8 |url=}}</ref><ref name="myelofibrosisdiffdiagnsosiseradio1">Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name="Diffusebonysclerosisdifferentialdiagnosis1">Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016</ref> | ||
==Differentiating Myelofibrosis from other Diseases== | ==Differentiating Myelofibrosis from other Diseases== | ||
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, anemia, leukopenia, thrombocytopenia, leukocytosis, or thrombocytosis. They are presented in the table below.<ref name="pmid23693053">{{cite journal |vauthors=Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ |title=Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis |journal=Int J Lab Hematol |volume=35 |issue=6 |pages=629–36 |date=December 2013 |pmid=23693053 |doi=10.1111/ijlh.12101 |url=}}</ref><ref name="pmid25124313">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=9 |pages=915–25 |date=September 2014 |pmid=25124313 |doi=10.1002/ajh.23703 |url=}}</ref><ref name="pmid23349007">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=88 |issue=2 |pages=141–50 |date=February 2013 |pmid=23349007 |doi=10.1002/ajh.23384 |url=}}</ref><ref name=myelofibrosisdiffdiagnsosiseradio1>Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name=Diffusebonysclerosisdifferentialdiagnosis1>Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016</ref> | [[Myelofibrosis]] must be differentiated from other [[Disease|diseases]] that cause diffuse [[bone]] [[sclerosis]], [[anemia]], [[leukopenia]], [[thrombocytopenia]], [[leukocytosis]], or [[thrombocytosis]]. They are presented in the table below.<ref name="pmid23693053">{{cite journal |vauthors=Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ |title=Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis |journal=Int J Lab Hematol |volume=35 |issue=6 |pages=629–36 |date=December 2013 |pmid=23693053 |doi=10.1111/ijlh.12101 |url=}}</ref><ref name="pmid25124313">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=89 |issue=9 |pages=915–25 |date=September 2014 |pmid=25124313 |doi=10.1002/ajh.23703 |url=}}</ref><ref name="pmid23349007">{{cite journal |vauthors=Tefferi A |title=Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=88 |issue=2 |pages=141–50 |date=February 2013 |pmid=23349007 |doi=10.1002/ajh.23384 |url=}}</ref><ref name="myelofibrosisdiffdiagnsosiseradio1">Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref><ref name="Diffusebonysclerosisdifferentialdiagnosis1">Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016</ref> | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width:650px" | {| style="border: 0px; font-size: 90%; margin: 3px; width:650px" | ||
|valign=top| | | valign="top" | | ||
|+ | |+ | ||
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}} | ! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}} | ||
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}} | ! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}} | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Hematological | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Hematological | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Sickle cell disease]] | *[[Sickle cell disease]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Metabolic bone disorders | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align="center" |Metabolic bone disorders | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Hyperthyroidism]] | *[[Hyperthyroidism]] | ||
| Line 25: | Line 25: | ||
*[[Renal osteodystrophy]] | *[[Renal osteodystrophy]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Congenital | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Congenital | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[dysplasia|Sclerosing bone dysplasia]] | *[[dysplasia|Sclerosing bone dysplasia]] | ||
| Line 31: | Line 31: | ||
*[[Pyknodysostosis]] | *[[Pyknodysostosis]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Malignancy | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Malignancy | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Lymphoma]]: infiltration | *[[Lymphoma]]: infiltration | ||
| Line 39: | Line 39: | ||
:*[[breast cancer]] | :*[[breast cancer]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Other | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Other | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Paget disease]] | *[[Paget disease]] | ||
| Line 47: | Line 47: | ||
|} | |} | ||
Myelofibrosis must also be differentiated from other diseases that cause [[splenomegaly]] and/or extramedullary hematopoiesis. They are presented in the table below.<ref name=splenomegalydiffdiagnosisradio1>Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/''Italic text''articles/splenomegaly. Accessed on March 11, 2016</ref><ref name="pmid24196613">{{cite journal |vauthors=Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL |title=[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis] |language=German |journal=Pathologe |volume=34 Suppl 2 |issue= |pages=201–9 |date=November 2013 |pmid=24196613 |doi=10.1007/s00292-013-1824-8 |url=}}</ref><ref name=myelofibrosisdiffdiagnsosiseradio1>Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref> | [[Myelofibrosis]] must also be differentiated from other [[Disease|diseases]] that cause [[splenomegaly]] and/or [[Extramedullary hematopoiesis|extramedullary hematopoiesis (EMH)]]. They are presented in the table below.<ref name="splenomegalydiffdiagnosisradio1">Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/''Italic text''articles/splenomegaly. Accessed on March 11, 2016</ref><ref name="pmid24196613">{{cite journal |vauthors=Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL |title=[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis] |language=German |journal=Pathologe |volume=34 Suppl 2 |issue= |pages=201–9 |date=November 2013 |pmid=24196613 |doi=10.1007/s00292-013-1824-8 |url=}}</ref><ref name="myelofibrosisdiffdiagnsosiseradio1">Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016</ref> | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width:650px" | {| style="border: 0px; font-size: 90%; margin: 3px; width:650px" | ||
|valign=top| | | valign="top" | | ||
|+ | |+ | ||
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}} | ! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type of diseases}} | ||
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}} | ! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Diseases}} | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Hematological causes | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Hematological causes | ||
| style="padding: 5px 5px; background: #F5F5F5;" |'''Anemia''' | | style="padding: 5px 5px; background: #F5F5F5;" |'''Anemia''' | ||
*[[Sickle cell disease]] | *[[Sickle cell disease]] | ||
| Line 70: | Line 70: | ||
<sub>* = may cause massive splenomegaly</sub> | <sub>* = may cause massive splenomegaly</sub> | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Hemodynamic | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align="center" |Hemodynamic | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Portal hypertension]] in the setting of [[cirrhosis]] | *[[Portal hypertension]] in the setting of [[cirrhosis]] | ||
| Line 78: | Line 78: | ||
*[[Right heart failure]] | *[[Right heart failure]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Infections | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Infections | ||
| style="padding: 5px 5px; background: #F5F5F5;" |'''Viral''' | | style="padding: 5px 5px; background: #F5F5F5;" |'''Viral''' | ||
*[[Infectious mononucleosis]] | *[[Infectious mononucleosis]] | ||
*[[Acquired immunodeficiency syndrome (AIDS)]] | *[[Acquired immunodeficiency syndrome|Acquired immunodeficiency syndrome (AIDS)]] | ||
*Cytomegalovirus (CMV) viremia | *[[Cytomegalovirus|Cytomegalovirus (CMV)]] [[viremia]] | ||
*Disseminated Herpes simplex virus (HSV) infection | *Disseminated [[Herpes simplex virus (HSV)]] [[infection]] | ||
*Rubella infection | *[[Rubella]] [[infection]] | ||
'''Bacterial''' | '''Bacterial''' | ||
*Miliary tuberculosis | *[[Miliary tuberculosis]] | ||
*[[Tularemia]] | *[[Tularemia]] | ||
*[[Subacute bacterial endocarditis]] | *[[Subacute bacterial endocarditis]] | ||
| Line 100: | Line 100: | ||
*[[Schistosomiasis]] | *[[Schistosomiasis]] | ||
*[[Hydatid disease]] | *[[Hydatid disease]] | ||
*[[Leishmaniasis (kala-azar)]] | *[[Leishmaniasis|Leishmaniasis (kala-azar)]] | ||
*[[Rickettsial disease]] | *[[Rickettsial disease]] | ||
*[[Typhus]] | *[[Typhus]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Storage/metabolic/infiltrative disorders | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Storage/metabolic/infiltrative disorders | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Glycogen storage diseases]] | *[[Glycogen storage diseases]] | ||
| Line 113: | Line 113: | ||
*[[Sarcoidosis]] | *[[Sarcoidosis]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Neoplastic | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Neoplastic | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Lymphoma]] | *[[Lymphoma]] | ||
*[[Metastases]] from primary malignancies such as: | *[[Metastases]] from primary [[malignancies]] such as: | ||
:*Breast carcinoma | :*[[Breast carcinoma]] | ||
:*Lung carcinoma | :*[[Lung carcinoma]] | ||
:*Colon carcinoma | :*[[Colon carcinoma]] | ||
:*Ovarian carcinoma | :*[[Ovarian carcinoma]] | ||
:*Melanoma | :*[[Melanoma]] | ||
:*[[Hemangioma]] | :*[[Hemangioma]] | ||
:*[[Lymphangioma]] | :*[[Lymphangioma]] | ||
:*[[Angiosarcoma]] | :*[[Angiosarcoma]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Trauma | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Trauma | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Hematoma]] | *[[Hematoma]] | ||
*[[Pseudocyst]] | *[[Pseudocyst]] | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |Connective tissue disorders | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align="center" |Connective tissue disorders | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*[[Systemic lupus erythematosus (SLE)]] | *[[Systemic lupus erythematosus|Systemic lupus erythematosus (SLE)]] | ||
*[[Rheumatoid arthritis]] | *[[Rheumatoid arthritis]] | ||
*[[Felty's syndrome]] | *[[Felty's syndrome]] | ||
Revision as of 19:25, 11 December 2018
|
Myelofibrosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Myelofibrosis differential diagnosis On the Web |
|
American Roentgen Ray Society Images of Myelofibrosis differential diagnosis |
|
Risk calculators and risk factors for Myelofibrosis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2], Sujit Routray, M.D. [3]
Overview
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, splenomegaly, anemia, leukopenia, thrombocytopenia, leukocytosis, thrombocytosis, and extramedullary hematopoiesis (EMH) such as sickle cell disease, hyperthyroidism, sclerosing bone dysplasia, osteoblastic metastases, Paget's disease, acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), polycythemia vera (PV), myelodysplastic syndrome, chronic myelomonocytic leukemia, acute panmyelosis, acute megakaryoblastic leukemia, cirrhosis, infections, neoplastic and lipid storage disorders.[1][2][3][4][5][6][7]
Differentiating Myelofibrosis from other Diseases
Myelofibrosis must be differentiated from other diseases that cause diffuse bone sclerosis, anemia, leukopenia, thrombocytopenia, leukocytosis, or thrombocytosis. They are presented in the table below.[2][3][4][6][7]
| Type of diseases | Diseases |
|---|---|
| Hematological | |
| Metabolic bone disorders | |
| Congenital | |
| Malignancy |
|
| Other |
|
Myelofibrosis must also be differentiated from other diseases that cause splenomegaly and/or extramedullary hematopoiesis (EMH). They are presented in the table below.[1][5][6]
| Type of diseases | Diseases |
|---|---|
| Hematological causes | Anemia
Neoplastic/proliferative/redistribution of hematopoesis
* = may cause massive splenomegaly |
| Hemodynamic | |
| Infections | Viral
Bacterial
Fungal Parasitic disease |
| Storage/metabolic/infiltrative disorders | |
| Neoplastic |
|
| Trauma | |
| Connective tissue disorders |
References
- ↑ 1.0 1.1 Splenomegaly. Dr Henry Knipe and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/Italic textarticles/splenomegaly. Accessed on March 11, 2016
- ↑ 2.0 2.1 Bae E, Park CJ, Cho YU, Seo EJ, Chi HS, Jang S, Lee KH, Lee JH, Lee JH, Suh JJ, Im HJ (December 2013). "Differential diagnosis of myelofibrosis based on WHO 2008 criteria: acute panmyelosis with myelofibrosis, acute megakaryoblastic leukemia with myelofibrosis, primary myelofibrosis and myelodysplastic syndrome with myelofibrosis". Int J Lab Hematol. 35 (6): 629–36. doi:10.1111/ijlh.12101. PMID 23693053.
- ↑ 3.0 3.1 Tefferi A (September 2014). "Primary myelofibrosis: 2014 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 89 (9): 915–25. doi:10.1002/ajh.23703. PMID 25124313.
- ↑ 4.0 4.1 Tefferi A (February 2013). "Primary myelofibrosis: 2013 update on diagnosis, risk-stratification, and management". Am. J. Hematol. 88 (2): 141–50. doi:10.1002/ajh.23384. PMID 23349007.
- ↑ 5.0 5.1 Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL (November 2013). "[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis]". Pathologe (in German). 34 Suppl 2: 201–9. doi:10.1007/s00292-013-1824-8. PMID 24196613.
- ↑ 6.0 6.1 6.2 Differential diagnosis of myelofibrosis. Dr Henry Knipe and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/myelofibrosis. Accessed on March 10, 2016
- ↑ 7.0 7.1 Diffuse bony sclerosis: differential diagnosis. Dr Craig Hacking and Dr Yuranga Weerakkody et al. Radiopaedia 2016. http://radiopaedia.org/articles/diffuse-bony-sclerosis-differential-diagnosis. Accessed on March 10, 2016