Thrombotic thrombocytopenic purpura history and symptoms: Difference between revisions
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===Common Symptoms=== | ===Common Symptoms=== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3]
Overview
The majority of patients with TTP are asymptomatic. However, the classic pentad of signs/symptoms includes microangiopathic hemolytic anemia, renal failure, thrombocytopenia, neurologic dysfunction, and fever.
History and Symptoms
History
Patients with TTP may have a positive history of:[1]
| Clinical history of TTP | |
|---|---|
| Thrombocytopenia | Epistaxis, bruising, petechiae, gingival bleeding, haematuria, menorrhagia, gastrointestinal bleeding, retinal haemorrhage and haemoptysis |
| Central neurological | Confusion, headache, paresis, aphasia, dysarthria, visual problems, encephalopathy, stroke-like symptom, coma (10%) |
| Renal Impairment | Proteinuria, microhaematuria |
| Non-specific symptoms | Pallor, jaundice, fatigue, arthralgia or myalgia |
| Jaundice | Resulting from microangiopathic haemolytic anaemia |
| Cardiac | Chest pain, heart failure, hypotension |
| Gastro-intestinal tract(GI) | Abdominal pain, nausea and vomiting |
| Skin | Skin bleeding – purpura and petechiae |
Common Symptoms
Common symptoms of [disease] include:[2][3]
- History of autoimmune disease like SLE
- History of surgery or transplant
- Drug history
- Initial symptoms: Fatigue, pale and/or red skin, shortness of breath, bruises, bleeding
- Headache
- Numbness
- Weakness
- Dizziness
- Palpitation
- Abdominal pain
- Easy bruising
- Nausea and vomiting
- Fever
- Changes in the urine
Less Common Symptoms
Less common symptoms of TTP include:
- Chills
- Chest pain
- Cough
References
- ↑ Scully M, Hunt BJ, Benjamin S, Liesner R, Rose P, Peyvandi F, Cheung B, Machin SJ (August 2012). "Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies". Br. J. Haematol. 158 (3): 323–35. doi:10.1111/j.1365-2141.2012.09167.x. PMID 22624596.
- ↑ Griffin D, Al-Nouri ZL, Muthurajah D, Ross JR, Ballard RB, Terrell DR; et al. (2013). "First symptoms in patients with thrombotic thrombocytopenic purpura: what are they and when do they occur?". Transfusion. 53 (1): 235–7. doi:10.1111/j.1537-2995.2012.03934.x. PMC 3541531. PMID 23294213.
- ↑ Medina PJ, Sipols JM, George JN (September 2001). "Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome". Curr. Opin. Hematol. 8 (5): 286–93. PMID 11604563.