Breast lumps differential diagnosis: Difference between revisions
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[[Breast lumps]] must be differentiated from other diseases such as [[malignancy]], [[cysts]], [[inflammation]] and non-inflammatory solid lumps. | [[Breast lumps]] must be differentiated from other diseases such as [[malignancy]], [[cysts]], [[inflammation]] and non-inflammatory solid lumps. | ||
Breast symptoms such as [[nipple discharge]] and [[mastalgia]] require assessment as well <ref name="pmid15691804" />. | |||
==Differentiating Breast lumps from other Diseases== | ==Differentiating Breast lumps from other Diseases== | ||
Differential diagnosis of [[breast lumps]] include: <ref name="pmid15691804">{{cite journal| author=Cheung KL, Lam TP| title=Approach to a lump in the breast: a regional perspective. | journal=Asian J Surg | year= 2005 | volume= 28 | issue= 1 | pages= 65-70 | pmid=15691804 | doi=10.1016/S1015-9584(09)60264-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15691804 }} </ref> | Differential diagnosis of [[breast lumps]] include: <ref name="pmid15691804">{{cite journal| author=Cheung KL, Lam TP| title=Approach to a lump in the breast: a regional perspective. | journal=Asian J Surg | year= 2005 | volume= 28 | issue= 1 | pages= 65-70 | pmid=15691804 | doi=10.1016/S1015-9584(09)60264-5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15691804 }} </ref> | ||
*Malignancy or breast cancer | *[[Malignancy]] or [[breast cancer]] | ||
**Associated with following factors:<ref>@article{Collyar2001BreastCA, | **Associated with following factors:<ref>@article{Collyar2001BreastCA, | ||
title={Breast cancer: a global perspective.}, | title={Breast cancer: a global perspective.}, | ||
| Line 19: | Line 19: | ||
}</ref> | }</ref> | ||
***geographical area | ***geographical area | ||
*** age | *** [[age]] | ||
***ethnicity | ***ethnicity | ||
***positive family history | ***positive [[family history]] | ||
*** pathology results such as: | *** [[pathology]] results such as: | ||
****Atypical ductal hyperplasia (ADH) | ****Atypical ductal [[hyperplasia]] (ADH) | ||
****Atypical lobular hyperplasia(ALH) | ****Atypical lobular hyperplasia(ALH) | ||
****Lobular carcinoma in situ(LCIS) | ****[[Lobular carcinoma in situ]](LCIS) | ||
***Previous history of | ***Previous history of [[radiotherapy]] | ||
*Inflammatory lumps:<ref name="pmid3307689">{{cite journal| author=Lang AP, Luchsinger IS, Rawling EG| title=Filariasis of the breast. | journal=Arch Pathol Lab Med | year= 1987 | volume= 111 | issue= 8 | pages= 757-9 | pmid=3307689 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3307689 }} </ref><ref name="pmid8629415">{{cite journal| author=Varghese R, Raghuveer CV, Pai MR, Bansal R| title=Microfilariae in cytologic smears: a report of six cases. | journal=Acta Cytol | year= 1996 | volume= 40 | issue= 2 | pages= 299-301 | pmid=8629415 | doi=10.1159/000333755 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8629415 }} </ref> | *[[Inflammatory]] lumps:<ref name="pmid3307689">{{cite journal| author=Lang AP, Luchsinger IS, Rawling EG| title=Filariasis of the breast. | journal=Arch Pathol Lab Med | year= 1987 | volume= 111 | issue= 8 | pages= 757-9 | pmid=3307689 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3307689 }} </ref><ref name="pmid8629415">{{cite journal| author=Varghese R, Raghuveer CV, Pai MR, Bansal R| title=Microfilariae in cytologic smears: a report of six cases. | journal=Acta Cytol | year= 1996 | volume= 40 | issue= 2 | pages= 299-301 | pmid=8629415 | doi=10.1159/000333755 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8629415 }} </ref> | ||
**Associated to personal habit and disease pattern: | **Associated to personal habit and disease pattern: | ||
***Infective lumps | ***Infective lumps | ||
****Lactational mastitis or abscess | ****Lactational [[mastitis]] or [[abscess]] | ||
****Non-lactational mastitis | ****Non-lactational [[mastitis]] | ||
*****Periductal mastitis in chronic smokers | *****Periductal [[mastitis]] in chronic smokers | ||
*****Lobular mastitis in tuberculosis and parasitic infection | *****[[Lobular]] [[mastitis]] in tuberculosis and parasitic infection | ||
***Non-infective lumps such as chronic granulomatous infection | ***Non-infective lumps such as chronic [[granulomatous]] infection | ||
*Solid non-inflammatory lumps <ref>Alagaratnam, T.T. & Wong, J. World J. Surg. (1989) 13: 743. https://doi.org/10.1007/BF01658425</ref> <ref name="pmid2623884">{{cite journal| author=Shukla HS, Kumar S| title=Benign breast disorders in nonwestern populations: Part II--Benign breast disorders in India. | journal=World J Surg | year= 1989 | volume= 13 | issue= 6 | pages= 746-9 | pmid=2623884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2623884 }} </ref> | *Solid non-inflammatory lumps <ref>Alagaratnam, T.T. & Wong, J. World J. Surg. (1989) 13: 743. https://doi.org/10.1007/BF01658425</ref> <ref name="pmid2623884">{{cite journal| author=Shukla HS, Kumar S| title=Benign breast disorders in nonwestern populations: Part II--Benign breast disorders in India. | journal=World J Surg | year= 1989 | volume= 13 | issue= 6 | pages= 746-9 | pmid=2623884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2623884 }} </ref> | ||
**Related to age, geographical area and ethnicity | **Related to age, geographical area and ethnicity | ||
**Mostly fibroadenomas in women aged 20-30 years | **Mostly [[Fibroadenoma|fibroadenomas]] in women aged 20-30 years | ||
**Phyllodes | **Phyllodes tumor are prevalent in various centers,racial groups in different frequencies | ||
*Cysts<ref name="pmid11574178">{{cite journal| author=Leung TN, Haines CJ, Chung TK| title=Five-year compliance with hormone replacement therapy in postmenopausal Chinese women in Hong Kong. | journal=Maturitas | year= 2001 | volume= 39 | issue= 3 | pages= 195-201 | pmid=11574178 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11574178 }} </ref> | *[[Cysts]]<ref name="pmid11574178">{{cite journal| author=Leung TN, Haines CJ, Chung TK| title=Five-year compliance with hormone replacement therapy in postmenopausal Chinese women in Hong Kong. | journal=Maturitas | year= 2001 | volume= 39 | issue= 3 | pages= 195-201 | pmid=11574178 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11574178 }} </ref> | ||
**Related to age and usage of hormonal replacement therapy | **Related to age and usage of [[Hormone replacement therapy|hormonal replacement therapy]] | ||
**Symptomatic cysts are often seen in women age 30years to early 50 years | **Symptomatic [[cysts]] are often seen in women age 30years to early 50 years | ||
**If menopausaed women may be present due to hormone replacement therapy (HRT) | **If menopausaed women may be present due to [[hormone replacement therapy]] (HRT) | ||
Revision as of 18:03, 21 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Breast lumps must be differentiated from other diseases such as malignancy, cysts, inflammation and non-inflammatory solid lumps.
Breast symptoms such as nipple discharge and mastalgia require assessment as well [1].
Differentiating Breast lumps from other Diseases
Differential diagnosis of breast lumps include: [1]
- Malignancy or breast cancer
- Associated with following factors:[2]
- geographical area
- age
- ethnicity
- positive family history
- pathology results such as:
- Atypical ductal hyperplasia (ADH)
- Atypical lobular hyperplasia(ALH)
- Lobular carcinoma in situ(LCIS)
- Previous history of radiotherapy
- Associated with following factors:[2]
- Inflammatory lumps:[3][4]
- Solid non-inflammatory lumps [5] [6]
- Related to age, geographical area and ethnicity
- Mostly fibroadenomas in women aged 20-30 years
- Phyllodes tumor are prevalent in various centers,racial groups in different frequencies
- Cysts[7]
- Related to age and usage of hormonal replacement therapy
- Symptomatic cysts are often seen in women age 30years to early 50 years
- If menopausaed women may be present due to hormone replacement therapy (HRT)
References
- ↑ 1.0 1.1 Cheung KL, Lam TP (2005). "Approach to a lump in the breast: a regional perspective". Asian J Surg. 28 (1): 65–70. doi:10.1016/S1015-9584(09)60264-5. PMID 15691804.
- ↑ @article{Collyar2001BreastCA, title={Breast cancer: a global perspective.}, author={Deborah E. Collyar}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2001}, volume={19 18 Suppl}, pages={101S-105S} }
- ↑ Lang AP, Luchsinger IS, Rawling EG (1987). "Filariasis of the breast". Arch Pathol Lab Med. 111 (8): 757–9. PMID 3307689.
- ↑ Varghese R, Raghuveer CV, Pai MR, Bansal R (1996). "Microfilariae in cytologic smears: a report of six cases". Acta Cytol. 40 (2): 299–301. doi:10.1159/000333755. PMID 8629415.
- ↑ Alagaratnam, T.T. & Wong, J. World J. Surg. (1989) 13: 743. https://doi.org/10.1007/BF01658425
- ↑ Shukla HS, Kumar S (1989). "Benign breast disorders in nonwestern populations: Part II--Benign breast disorders in India". World J Surg. 13 (6): 746–9. PMID 2623884.
- ↑ Leung TN, Haines CJ, Chung TK (2001). "Five-year compliance with hormone replacement therapy in postmenopausal Chinese women in Hong Kong". Maturitas. 39 (3): 195–201. PMID 11574178.