Merkel cell cancer classification: Difference between revisions
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{{CMG}} {{AE}} {{AAM}} | {{CMG}} {{AE}} {{AAM}} | ||
==Overview== | ==Overview== | ||
[[Merkel cell carcinoma]] is classified into 3 subgroups: trabecular, intermediate, and small cell. | |||
==Classification== | ==Classification== | ||
Histologically, MCC has been classified into three distinct subtypes:<ref name="pmid3724197">{{cite journal |vauthors=Suster S, Ronnen M, Lin E, Shewach-Millet M |title=Trabecular carcinoma of the skin simulating metastatic disease |journal=J Surg Oncol |volume=32 |issue=2 |pages=73–5 |date=June 1986 |pmid=3724197 |doi= |url=}}</ref><ref name="pmid1698390">{{cite journal |vauthors=Johansson L, Tennvall J, Akerman M |title=Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature |journal=APMIS |volume=98 |issue=8 |pages=741–52 |date=August 1990 |pmid=1698390 |doi= |url=}}</ref> | Histologically, [[MCC]] has been classified into three distinct subtypes:<ref name="pmid3724197">{{cite journal |vauthors=Suster S, Ronnen M, Lin E, Shewach-Millet M |title=Trabecular carcinoma of the skin simulating metastatic disease |journal=J Surg Oncol |volume=32 |issue=2 |pages=73–5 |date=June 1986 |pmid=3724197 |doi= |url=}}</ref><ref name="pmid1698390">{{cite journal |vauthors=Johansson L, Tennvall J, Akerman M |title=Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature |journal=APMIS |volume=98 |issue=8 |pages=741–52 |date=August 1990 |pmid=1698390 |doi= |url=}}</ref> | ||
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|Solid pattern | |Solid pattern | ||
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* Most common type | * Most common subtype | ||
* Compactly arranged cells | |||
* Cytoplasm is less abundant in the cells | |||
* Mitotic figures are positive | |||
* Necrosis is positive | |||
* Intermediate type may invade the epidermis | |||
* More aggressive subtype when compared to the trabecular type | |||
* | * | ||
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Revision as of 17:58, 2 January 2019
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Merkel cell cancer Microchapters |
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Merkel cell cancer classification On the Web |
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Risk calculators and risk factors for Merkel cell cancer classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Merkel cell carcinoma is classified into 3 subgroups: trabecular, intermediate, and small cell.
Classification
Histologically, MCC has been classified into three distinct subtypes:[1][2]
| Subtype | Pattern | Histology studies |
|---|---|---|
| Trabecular type | Classic pattern |
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| Intermediate type | Solid pattern |
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| Small cell type | Diffuse pattern |
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References
- ↑ Suster S, Ronnen M, Lin E, Shewach-Millet M (June 1986). "Trabecular carcinoma of the skin simulating metastatic disease". J Surg Oncol. 32 (2): 73–5. PMID 3724197.
- ↑ Johansson L, Tennvall J, Akerman M (August 1990). "Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and a review of the literature". APMIS. 98 (8): 741–52. PMID 1698390.