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| {{CMG}}; {{AE}} {{Trusha}} | | {{CMG}}; {{AE}} {{Trusha}} |
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| ==Overview== | | ==Overview== |
| There are no direct causes of sarcomatoid carcinoma of the lung. However, there are a few risk factors that can lead to genetic mutation and cause sarcomatoid carcinoma of the lung.
| | The direct cause of sarcomatoid carcinoma of the lung is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both. The risk of these genetic mutations may be increased following exposure to environmental components. |
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| ==Causes== | | ==Causes== |
| ===Life-threatening Causes===
| | *The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. '''[[KRAS|K-RAS]]''') or the inactivation of [[Tumor suppressor gene|tumors suppressor genes]] (e.g. '''[[TP53]]''') or both.<ref>American Cancer Society. Cancer Facts & Figures 2017. |
| *There are no direct causes of sarcomatoid carcinoma of the lung. However, there are a few risk factors that can lead to genetic mutation and cause sarcomatoid carcinoma of the lung. | | Atlanta: American Cancer Society; 2017.</ref><ref name="pmid23122493">{{cite journal |vauthors=Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R |title=KRAS mutations in lung cancer |journal=Clin Lung Cancer |volume=14 |issue=3 |pages=205–14 |year=2013 |pmid=23122493 |doi=10.1016/j.cllc.2012.09.007 |url=}}</ref> |
| | | *The risk of these genetic [[Mutation|mutations]] may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer. |
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| *[Disease name] is caused by an infection with [pathogen name].
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| *[Pathogen name] is caused by [pathogen name].
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| ===Less Common Causes===
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| Less common causes of [disease name] include:
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| *[Cause1]
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| *[Cause2]
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| *[Cause3]
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| ===Genetic Causes===
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| *[Disease name] is caused by a mutation in the [gene name] gene.
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| ===Causes by Organ System===
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| {|style="width:80%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
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| |style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
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| |-
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| |bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
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| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Dental'''
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| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Dermatologic''' | |
| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Drug Side Effect''' | |
| |bgcolor="Beige"| No underlying causes
| |
| |- | |
| |-bgcolor="LightSteelBlue"
| |
| | '''Ear Nose Throat''' | |
| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue" | |
| | '''Endocrine''' | |
| |bgcolor="Beige"| No underlying causes
| |
| |- | |
| |-bgcolor="LightSteelBlue"
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| | '''Environmental'''
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| |bgcolor="Beige"| No underlying causes
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| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Gastroenterologic'''
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| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Genetic'''
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| |bgcolor="Beige"| No underlying causes
| |
| |-
| |
| |-bgcolor="LightSteelBlue"
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| | '''Hematologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Iatrogenic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Infectious Disease'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Musculoskeletal/Orthopedic'''
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| |bgcolor="Beige"| No underlying causes | |
| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Neurologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Nutritional/Metabolic'''
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| |bgcolor="Beige"| No underlying causes | |
| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Obstetric/Gynecologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Oncologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Ophthalmologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Overdose/Toxicity'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Psychiatric'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Pulmonary'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Renal/Electrolyte'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Rheumatology/Immunology/Allergy'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Sexual'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Trauma'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Urologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Miscellaneous'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |}
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| ===Causes in Alphabetical Order===
| | *To view a comprehensive list of risk factors that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']] |
| List the causes of the disease in alphabetical order:
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| <div style="-moz-column-count:3; column-count:3;">
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| * Cause 1
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| * Cause 2
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| * Cause 3
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| * Cause 4
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| * Cause 5
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| * Cause 6
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| * Cause 7
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| * Cause 8
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| * Cause 9
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| * Cause 10
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| </div>
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| ==References== | | ==References== |
| {{Reflist|2}} | | {{reflist|2}} |
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| {{WH}}
| | [[Category:Disease]] |
| {{WS}}
| | [[Category:Types of cancer]] |
| [[Category: (name of the system)]] | | [[Category:Pulmonology]] |
| | [[Category:Lung cancer]] |
| | [[Category:Oncology]] |
| | [[Category:Medicine]] |
| | [[Category:Pulmonology]] |
| | [[Category:Surgery]] |
Template:Sarcomatoid carcinoma of the lung causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2]
Overview
The direct cause of sarcomatoid carcinoma of the lung is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental components.
Causes
- The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumors suppressor genes (e.g. TP53) or both.[1][2]
- The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
- To view a comprehensive list of risk factors that increase the risk of lung cancer, click here
References
- ↑ American Cancer Society. Cancer Facts & Figures 2017.
Atlanta: American Cancer Society; 2017.
- ↑ Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.