Sarcomatoid carcinoma of the lung causes: Difference between revisions
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{{Sarcomatoid carcinoma of the lung causes}} | {{Sarcomatoid carcinoma of the lung causes}} | ||
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==Overview== | ==Overview== | ||
The direct cause of sarcomatoid carcinoma of the lung is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. [[KRAS|K-RAS]]) or the inactivation of [[Tumor suppressor gene| | The direct cause of sarcomatoid carcinoma of the lung is [[DNA mutations]] that often result in either activation of [[Proto-oncogene|proto-oncogenes]] (e.g. [[KRAS|K-RAS]]) or the inactivation of [[Tumor suppressor gene|tumor suppressor genes]] (e.g. [[TP53]]) or both. The risk of these genetic mutations may be increased following exposure to environmental components. | ||
==Causes== | ==Causes== | ||
*The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. | *The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. [[KRAS|K-RAS]]) or the inactivation of [[Tumor suppressor gene|tumor suppressor genes]] (e.g. [[TP53]]) or both.<ref name="pmid23122493">{{cite journal |vauthors=Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R |title=KRAS mutations in lung cancer |journal=Clin Lung Cancer |volume=14 |issue=3 |pages=205–14 |year=2013 |pmid=23122493 |doi=10.1016/j.cllc.2012.09.007 |url=}}</ref> | ||
*The risk of these genetic [[Mutation|mutations]] may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer. | *The risk of these genetic [[Mutation|mutations]] may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer. | ||
*To view a comprehensive list of risk factors that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']] | *To view a comprehensive list of risk factors that increase the risk of lung cancer, click [[Lung cancer risk factors|'''here''']]. | ||
==References== | ==References== | ||
Revision as of 16:42, 3 January 2019
Template:Sarcomatoid carcinoma of the lung causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2]
Overview
The direct cause of sarcomatoid carcinoma of the lung is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumor suppressor genes (e.g. TP53) or both. The risk of these genetic mutations may be increased following exposure to environmental components.
Causes
- The direct cause of lung cancers is DNA mutations that often result in either activation of proto-oncogenes (e.g. K-RAS) or the inactivation of tumor suppressor genes (e.g. TP53) or both.[1]
- The risk of these genetic mutations may be increased following exposure to environmental components, which are regarded as risk factors that predispose to the development of lung cancer.
- To view a comprehensive list of risk factors that increase the risk of lung cancer, click here.
References
- ↑ Karachaliou N, Mayo C, Costa C, Magrí I, Gimenez-Capitan A, Molina-Vila MA, Rosell R (2013). "KRAS mutations in lung cancer". Clin Lung Cancer. 14 (3): 205–14. doi:10.1016/j.cllc.2012.09.007. PMID 23122493.