Carcinoid syndrome causes: Difference between revisions
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==Causes== | ==Causes== | ||
*Approximately 30-40% of patients with well-differentiated neuroendocrine tumors present with carcinoid syndrome. | |||
*Carcinoid syndrome is predominantly associated with neuroendocrine tumors (NETs) that arise from the midgut in the setting of extensive liver metastases | |||
* Carcinoid syndrome may be present in patients with bronchial carcinoids.<ref name="pmid30133565">{{cite journal |vauthors=Rubin de Celis Ferrari AC, Glasberg J, Riechelmann RP |title=Carcinoid syndrome: update on the pathophysiology and treatment |journal=Clinics (Sao Paulo) |volume=73 |issue=suppl 1 |pages=e490s |date=August 2018 |pmid=30133565 |pmc=6096975 |doi=10.6061/clinics/2018/e490s |url=}}</ref> | |||
* other common causes of carcinoid syndrome includes are mostly genetic:<ref name=aaa>Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | |||
*'''Genetic disorders''' | *'''Genetic disorders''' | ||
Revision as of 19:39, 7 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Common causes of carcinoid syndrome include genetic disorders (multiple endocrine neoplasia type 1 and neurofibromatosis type 1) and genetic mutations (gains involving chromosomes 5, 14, 17, and 19 and losses involving chromosomes 11 and 18).
Causes
- Approximately 30-40% of patients with well-differentiated neuroendocrine tumors present with carcinoid syndrome.
- Carcinoid syndrome is predominantly associated with neuroendocrine tumors (NETs) that arise from the midgut in the setting of extensive liver metastases
- Carcinoid syndrome may be present in patients with bronchial carcinoids.[1]
- other common causes of carcinoid syndrome includes are mostly genetic:[2]
- Genetic disorders
| Genetic Disorder | Tumor Location |
|---|---|
| |
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- Genetic mutations
| Type of Mutation | Chromosomes |
|---|---|
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Gains |
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Losses |
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References
- ↑ Rubin de Celis Ferrari AC, Glasberg J, Riechelmann RP (August 2018). "Carcinoid syndrome: update on the pathophysiology and treatment". Clinics (Sao Paulo). 73 (suppl 1): e490s. doi:10.6061/clinics/2018/e490s. PMC 6096975. PMID 30133565.
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq