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| {{CMG}}; {{AE}} {{Badria}} | | {{CMG}}; {{AE}} {{Badria}} |
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| ==Thyroid Disorders==
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| Thyroid disorders are divided into two major categories.
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| *Hyperthyroidism*<ref name="pmid29754056">{{cite journal |vauthors=Rong S, Gao Y, Yang Y, Shao H, Okekunle AP, Lv C, Du Y, Sun H, Jiang Y, Darko GM, Sun D |title=Nitric oxide is involved in the hypothyroidism with significant morphology changes in female Wistar rats induced by chronic exposure to high water iodine from potassium iodate |journal=Chemosphere |volume=206 |issue= |pages=320–329 |date=September 2018 |pmid=29754056 |doi=10.1016/j.chemosphere.2018.05.015 |url=}}</ref>
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| *Hypothyroidism*<ref name="pmid30224619">{{cite journal |vauthors=Ikegami T, Yamamoto Y, Goto M, Kawagoe R, Kawada Y, Kusuhara K |title=A Pediatric Case of Graves' Hyperthyroidism with Associated Glucose Intolerance Detected by a Urine Glucose Screening Program at School |journal=J. UOEH |volume=40 |issue=3 |pages=231–236 |date=2018 |pmid=30224619 |doi=10.7888/juoeh.40.231 |url=}}</ref>
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| ===Hyperthyroidism===
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| The signs of hyperthyroidism are increased temperature.
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| ====Hypothyroidism====
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| *cold intolerance*
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| Other signs include skin changes.''Diff''<br>Constipation
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| Diagnosis can be made through laboratory findings
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| *TSH
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| **thyroglobulin levels
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| ***total t3
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| ****free t4
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| *radio iodine test
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| #antithyroid antibodies
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| ##antithyroid peroxidase antibodies
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| #TSH receptors antibodies
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| ;Radiological tests
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| :Ultrasound
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| :Radioiodine scanning
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| ;Biopsy
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| The '''Treatment''' therapy
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| Levothyroxine
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| Surgical Removal
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| :For Hyperthyroidism
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| Iodine Therapy
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| Surgical removal
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| Propothyrouracil
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| Methimazole
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| <center>The End</center>
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| ----
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| The End
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| *#Bullet points
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| *#*Point 1
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| *#*;Bold letters
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| *#*:without Semicolon
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| *#*:*Dell
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| *#*:*A
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| *#*:*B
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| *C
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| {|
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| |A ||B
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| |-
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| |C ||D
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| |}
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| The cause of Protein C deficiency is gene mutation in long arm (q) of chromosome 2 at position 14.3.
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| This mutation follows Autosomal Dominant Pattern of inheritance. However Homozygous cases present
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| Cytogenetic Location: 2q14.3, which is the long (q) arm of chromosome 2 at position 14.3
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| Protein C deficiency affects men and women in equal numbers. The prevalence of the milder form is about 1 in 200-500 people.\The prevalence of severe protein C deficiency is about 1 in 500,000-750,000 people in the general population.
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| Activated protein C indirectly increases the profibrinolytic activity by activating to tissue plasminogen activator (tPA)after binding to Plasminogen activator inhibitor (PAI). The reduced thrombin generation causes decreased the activation of TAFI (thrombin activatable fibrinolysis inhibitor) hence resulting in enhanced profibrinolytic potential.
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| ==References==
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| {{reflist|2}} | | {{reflist|2}} |