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{{Infobox_gene}}
{{Infobox_gene}}
'''Protein kinase C and casein kinase substrate in neurons protein 2''' (Pacsin 2) is a protein that in humans is encoded by the ''PACSIN2'' [[gene]].<ref name="pmid10431838">{{cite journal | vauthors = Ritter B, Modregger J, Paulsson M, Plomann M | title = PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins | journal = FEBS Lett | volume = 454 | issue = 3 | pages = 356–62 | date = Aug 1999 | pmid = 10431838 | pmc =  | doi = 10.1016/S0014-5793(99)00830-3 }}</ref><ref name="pmid11082044">{{cite journal | vauthors = Modregger J, Ritter B, Witter B, Paulsson M, Plomann M | title = All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis | journal = J Cell Sci | volume = 113 Pt 24 | issue =  | pages = 4511–21 | date = Jan 2001 | pmid = 11082044 | pmc =  | doi =  }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11252| accessdate = }}</ref> Pacsin 2 is involved in the formation of [[caveolae]].<ref>{{cite journal|last1=Shvets|first1=E|last2=Ludwig|first2=A|last3=Nichols|first3=BJ|title=News from the caves: update on the structure and function of caveolae.|journal=Current Opinion in Cell Biology|date=August 2014|volume=29|pages=99–106|pmid=24908346}}</ref>
'''Protein kinase C and casein kinase substrate in neurons protein 2''' (Pacsin 2) is a protein that in humans is encoded by the ''PACSIN2'' [[gene]].<ref name="pmid10431838">{{cite journal | vauthors = Ritter B, Modregger J, Paulsson M, Plomann M | title = PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins | journal = FEBS Lett | volume = 454 | issue = 3 | pages = 356–62 | date = Aug 1999 | pmid = 10431838 | pmc =  | doi = 10.1016/S0014-5793(99)00830-3 }}</ref><ref name="pmid11082044">{{cite journal | vauthors = Modregger J, Ritter B, Witter B, Paulsson M, Plomann M | title = All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis | journal = J Cell Sci | volume = 113 | issue =  24| pages = 4511–21 | date = Jan 2001 | pmid = 11082044 | pmc =  | doi =  }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11252| accessdate = }}</ref> Pacsin 2 is involved in the formation of [[caveolae]].<ref>{{cite journal|last1=Shvets|first1=E|last2=Ludwig|first2=A|last3=Nichols|first3=BJ|title=News from the caves: update on the structure and function of caveolae.|journal=Current Opinion in Cell Biology|date=August 2014|volume=29|pages=99–106|pmid=24908346|doi=10.1016/j.ceb.2014.04.011}}</ref>


== Interactions ==
== Interactions ==


PACSIN2 has been shown to [[Protein-protein interaction|interact]] with:
PACSIN2 has been shown to [[Protein-protein interaction|interact]] with:
* [[Fas ligand]],<ref name = pmid12023017>{{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1-3 | pages = 50–8 | date = May 2002 | pmid = 12023017 | doi =  10.1016/s0014-5793(02)02709-6}}</ref>
* [[Fas ligand]],<ref name = pmid12023017>{{cite journal | vauthors = Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O | title = Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178) | journal = FEBS Lett. | volume = 519 | issue = 1–3 | pages = 50–8 | date = May 2002 | pmid = 12023017 | doi =  10.1016/s0014-5793(02)02709-6}}</ref>
* [[PACSIN1]],<ref name = pmid11082044 /><ref name = pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>  and
* [[PACSIN1]],<ref name = pmid11082044 /><ref name = pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>  and
* [[PACSIN3]].<ref name = pmid11082044/>
* [[PACSIN3]].<ref name = pmid11082044/>

Revision as of 16:17, 27 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the PACSIN2 gene.[1][2][3] Pacsin 2 is involved in the formation of caveolae.[4]

Interactions

PACSIN2 has been shown to interact with:

References

  1. ↑ Ritter B, Modregger J, Paulsson M, Plomann M (Aug 1999). "PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins". FEBS Lett. 454 (3): 356–62. doi:10.1016/S0014-5793(99)00830-3. PMID 10431838.
  2. ↑ 2.0 2.1 2.2 Modregger J, Ritter B, Witter B, Paulsson M, Plomann M (Jan 2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J Cell Sci. 113 (24): 4511–21. PMID 11082044.
  3. ↑ "Entrez Gene: PACSIN2 protein kinase C and casein kinase substrate in neurons 2".
  4. ↑ Shvets, E; Ludwig, A; Nichols, BJ (August 2014). "News from the caves: update on the structure and function of caveolae". Current Opinion in Cell Biology. 29: 99–106. doi:10.1016/j.ceb.2014.04.011. PMID 24908346.
  5. ↑ Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O (May 2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. 519 (1–3): 50–8. doi:10.1016/s0014-5793(02)02709-6. PMID 12023017.
  6. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family". Gene. 262 (1–2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O (2002). "Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)". FEBS Lett. 519 (1–3): 50–8. doi:10.1016/S0014-5793(02)02709-6. PMID 12023017.
  • Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kessels MM, Dong J, Leibig W, Westermann P, Qualmann B (2006). "Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network". J. Cell Sci. 119 (Pt 8): 1504–16. doi:10.1242/jcs.02877. PMID 16551695.
  • Cuajungco MP, Grimm C, Oshima K, D'hoedt D, Nilius B, Mensenkamp AR, Bindels RJ, Plomann M, Heller S (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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