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{{Infobox_gene}}
{{Infobox_gene}}
'''Delta-like 4''' is a [[protein]] that in humans is encoded by the ''DLL4'' [[gene]].<ref name="pmid10837024">{{cite journal | vauthors = Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL | title = Dll4, a novel Notch ligand expressed in arterial endothelium | journal = Genes Dev | volume = 14 | issue = 11 | pages = 1313–8 |date=Jul 2000 | pmid = 10837024 | pmc = 316657 | doi = 10.1101/gad.14.11.1313 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567| accessdate = }}</ref>
'''Delta-like 4''' is a [[protein]] that in humans is encoded by the ''DLL4'' [[gene]].<ref name="pmid10837024">{{cite journal | vauthors = Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL | title = Dll4, a novel Notch ligand expressed in arterial endothelium | journal = Genes & Development | volume = 14 | issue = 11 | pages = 1313–8 | date = June 2000 | pmid = 10837024 | pmc = 316657 | doi = 10.1101/gad.14.11.1313 | doi-broken-date = 2018-11-07 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DLL4 delta-like 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54567| access-date = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a [[Sequence homology|homolog]] of the Drosophila delta gene. The delta gene family encodes [[Notch signaling pathway|Notch]] [[ligand|ligands]] that are characterized by a DSL domain, EGF repeats, and a [[Transmembrane protein|transmembrane]] domain.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.<ref name="entrez" />
}}


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yoneya T, Tahara T, Nagao K, Yamada Y, Yamamoto T, Osawa M, Miyatani S, Nishikawa M | title = Molecular cloning of delta-4, a new mouse and human Notch ligand | journal = Journal of Biochemistry | volume = 129 | issue = 1 | pages = 27–34 | date = January 2001 | pmid = 11134954 | doi = 10.1093/oxfordjournals.jbchem.a002832 }}
| citations =
* {{cite journal | vauthors = Yan XQ, Sarmiento U, Sun Y, Huang G, Guo J, Juan T, Van G, Qi MY, Scully S, Senaldi G, Fletcher FA | title = A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer | journal = Blood | volume = 98 | issue = 13 | pages = 3793–9 | date = December 2001 | pmid = 11739188 | doi = 10.1182/blood.V98.13.3793 }}
*{{cite journal | vauthors=Yoneya T, Tahara T, Nagao K |title=Molecular cloning of delta-4, a new mouse and human Notch ligand. |journal=J. Biochem. |volume=129 |issue= 1 |pages= 27–34 |year= 2001 |pmid= 11134954 |doi= 10.1093/oxfordjournals.jbchem.a002832|display-authors=etal}}
* {{cite journal | vauthors = Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D | title = Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis | journal = Differentiation; Research in Biological Diversity | volume = 69 | issue = 2–3 | pages = 135–44 | date = December 2001 | pmid = 11798067 | doi = 10.1046/j.1432-0436.2001.690207.x }}
*{{cite journal | vauthors=Yan XQ, Sarmiento U, Sun Y |title=A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. |journal=Blood |volume=98 |issue= 13 |pages= 3793–9 |year= 2002 |pmid= 11739188 |doi=10.1182/blood.V98.13.3793 |display-authors=etal}}
* {{cite journal | vauthors = Dorsch M, Zheng G, Yowe D, Rao P, Wang Y, Shen Q, Murphy C, Xiong X, Shi Q, Gutierrez-Ramos JC, Fraser C, Villeval JL | title = Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease | journal = Blood | volume = 100 | issue = 6 | pages = 2046–55 | date = September 2002 | pmid = 12200365 | doi =  }}
*{{cite journal | vauthors=Mailhos C, Modlich U, Lewis J |title=Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. |journal=Differentiation |volume=69 |issue= 2–3 |pages= 135–44 |year= 2002 |pmid= 11798067 |doi=10.1046/j.1432-0436.2001.690207.x |display-authors=etal}}
* {{cite journal | vauthors = Liu ZJ, Shirakawa T, Li Y, Soma A, Oka M, Dotto GP, Fairman RM, Velazquez OC, Herlyn M | title = Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis | journal = Molecular and Cellular Biology | volume = 23 | issue = 1 | pages = 14–25 | date = January 2003 | pmid = 12482957 | pmc = 140667 | doi = 10.1128/MCB.23.1.14-25.2003 }}
*{{cite journal | vauthors=Dorsch M, Zheng G, Yowe D |title=Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease |journal=Blood |volume=100 |issue= 6 |pages= 2046–55 |year= 2002 |pmid= 12200365 |doi=  |display-authors=etal}}
* {{cite journal | vauthors = Tohda S, Murata-Ohsawa M, Sakano S, Nara N | title = Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines | journal = International Journal of Oncology | volume = 22 | issue = 5 | pages = 1073–9 | date = May 2003 | pmid = 12684674 | doi = 10.3892/ijo.22.5.1073 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Shawber CJ, Das I, Francisco E, Kitajewski J | title = Notch signaling in primary endothelial cells | journal = Annals of the New York Academy of Sciences | volume = 995 | issue = | pages = 162–70 | date = May 2003 | pmid = 12814948 | doi = 10.1111/j.1749-6632.2003.tb03219.x }}
*{{cite journal | vauthors=Liu ZJ, Shirakawa T, Li Y |title=Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 14–25 |year= 2003 |pmid= 12482957 |doi=10.1128/MCB.23.1.14-25.2003  | pmc=140667  |display-authors=etal}}
* {{cite journal | vauthors = Lauret E, Catelain C, Titeux M, Poirault S, Dando JS, Dorsch M, Villeval JL, Groseil A, Vainchenker W, Sainteny F, Bennaceur-Griscelli A | title = Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential | journal = Leukemia | volume = 18 | issue = 4 | pages = 788–97 | date = April 2004 | pmid = 14990974 | doi = 10.1038/sj.leu.2403288 }}
*{{cite journal | vauthors=Tohda S, Murata-Ohsawa M, Sakano S, Nara N |title=Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines |journal=Int. J. Oncol. |volume=22 |issue= 5 |pages= 1073–9 |year= 2003 |pmid= 12684674 |doi= 10.3892/ijo.22.5.1073}}
* {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
*{{cite journal | vauthors=Shawber CJ, Das I, Francisco E, Kitajewski J |title=Notch signaling in primary endothelial cells |journal=Ann. N. Y. Acad. Sci. |volume=995 |issue= |pages= 162–70 |year= 2003 |pmid= 12814948 |doi=10.1111/j.1749-6632.2003.tb03219.x  }}
* {{cite journal | vauthors = McKeane DP, Meyer J, Dobrin SE, Melmed KM, Ekawardhani S, Tracy NA, Lesch KP, Stephan DA | title = No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families | journal = Schizophrenia Research | volume = 75 | issue = 1 | pages = 1–3 | date = June 2005 | pmid = 15820317 | doi = 10.1016/j.schres.2004.07.017 }}
*{{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
* {{cite journal | vauthors = Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL | title = Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function | journal = Cancer Research | volume = 65 | issue = 19 | pages = 8690–7 | date = October 2005 | pmid = 16204037 | doi = 10.1158/0008-5472.CAN-05-1208 }}
*{{cite journal | vauthors=Lauret E, Catelain C, Titeux M |title=Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential |journal=Leukemia |volume=18 |issue= 4 |pages= 788–97 |year= 2004 |pmid= 14990974 |doi= 10.1038/sj.leu.2403288 |display-authors=etal}}
* {{cite journal | vauthors = Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li JL, Harris AL | title = Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer | journal = Clinical Cancer Research | volume = 12 | issue = 16 | pages = 4836–44 | date = August 2006 | pmid = 16914569 | doi = 10.1158/1078-0432.CCR-06-0285 }}
*{{cite journal | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
* {{cite journal | vauthors = Lefort N, Benne C, Lelièvre JD, Dorival C, Balbo M, Sakano S, Coulombel L, Lévy Y | title = Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells | journal = Experimental Hematology | volume = 34 | issue = 12 | pages = 1720–9 | date = December 2006 | pmid = 17157169 | doi = 10.1016/j.exphem.2006.08.007 }}
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
* {{cite journal | vauthors = Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M | title = Delta-like 4 induces notch signaling in macrophages: implications for inflammation | journal = Circulation | volume = 115 | issue = 23 | pages = 2948–56 | date = June 2007 | pmid = 17533181 | doi = 10.1161/CIRCULATIONAHA.106.675462 }}
*{{cite journal | vauthors=McKeane DP, Meyer J, Dobrin SE |title=No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families |journal=[[Schizophrenia Research]] |volume=75 |issue= 1 |pages= 1–3 |year= 2005 |pmid= 15820317 |doi= 10.1016/j.schres.2004.07.017 |display-authors=etal}}
* {{cite journal | vauthors = Hodkinson PS, Elliott PA, Lad Y, McHugh BJ, MacKinnon AC, Haslett C, Sethi T | title = Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras | journal = The Journal of Biological Chemistry | volume = 282 | issue = 39 | pages = 28991–9001 | date = September 2007 | pmid = 17664272 | doi = 10.1074/jbc.M703601200 }}
*{{cite journal | vauthors=Patel NS, Li JL, Generali D |title=Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function |journal=Cancer Res. |volume=65 |issue= 19 |pages= 8690–7 |year= 2005 |pmid= 16204037 |doi= 10.1158/0008-5472.CAN-05-1208 |display-authors=etal}}
* {{cite journal | vauthors = Zang S, Ji C, Qu X, Dong X, Ma D, Ye J, Ma R, Dai J, Guo D | title = A study on Notch signaling in human breast cancer | journal = Neoplasma | volume = 54 | issue = 4 | pages = 304–10 | year = 2007 | pmid = 17822320 | doi =  }}
*{{cite journal | vauthors=Patel NS, Dobbie MS, Rochester M |title=Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer |journal=Clin. Cancer Res. |volume=12 |issue= 16 |pages= 4836–44 |year= 2006 |pmid= 16914569 |doi= 10.1158/1078-0432.CCR-06-0285 |display-authors=etal}}
*{{cite journal | vauthors=Lefort N, Benne C, Lelièvre JD |title=Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells |journal=Exp. Hematol. |volume=34 |issue= 12 |pages= 1720–9 |year= 2007 |pmid= 17157169 |doi= 10.1016/j.exphem.2006.08.007 |display-authors=etal}}
*{{cite journal  | vauthors=Fung E, Tang SM, Canner JP |title=Delta-like 4 induces notch signaling in macrophages: implications for inflammation |journal=Circulation |volume=115 |issue= 23 |pages= 2948–56 |year= 2007 |pmid= 17533181 |doi= 10.1161/CIRCULATIONAHA.106.675462 |display-authors=etal}}
*{{cite journal  | vauthors=Hodkinson PS, Elliott PA, Lad Y |title=Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras |journal=J. Biol. Chem. |volume=282 |issue= 39 |pages= 28991–9001 |year= 2007 |pmid= 17664272 |doi= 10.1074/jbc.M703601200 |display-authors=etal}}
*{{cite journal  | vauthors=Zang S, ((Ji Ch)), Qu X |title=A study on Notch signaling in human breast cancer |journal=Neoplasma |volume=54 |issue= 4 |pages= 304–10 |year= 2007 |pmid= 17822320 |doi=  |display-authors=etal}}
}}
{{refend}}
{{refend}}


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{{Notch signaling pathway}}
{{Notch signaling pathway}}


{{gene-15-stub}}
{{gene-15-stub}}

Revision as of 13:13, 7 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.[1][2]

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[2]

References

  1. ↑ Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL (June 2000). "Dll4, a novel Notch ligand expressed in arterial endothelium". Genes & Development. 14 (11): 1313–8. doi:10.1101/gad.14.11.1313 (inactive 2018-11-07). PMC 316657. PMID 10837024.
  2. ↑ 2.0 2.1 "Entrez Gene: DLL4 delta-like 4 (Drosophila)".

Further reading

  • Yoneya T, Tahara T, Nagao K, Yamada Y, Yamamoto T, Osawa M, Miyatani S, Nishikawa M (January 2001). "Molecular cloning of delta-4, a new mouse and human Notch ligand". Journal of Biochemistry. 129 (1): 27–34. doi:10.1093/oxfordjournals.jbchem.a002832. PMID 11134954.
  • Yan XQ, Sarmiento U, Sun Y, Huang G, Guo J, Juan T, Van G, Qi MY, Scully S, Senaldi G, Fletcher FA (December 2001). "A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer". Blood. 98 (13): 3793–9. doi:10.1182/blood.V98.13.3793. PMID 11739188.
  • Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D (December 2001). "Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis". Differentiation; Research in Biological Diversity. 69 (2–3): 135–44. doi:10.1046/j.1432-0436.2001.690207.x. PMID 11798067.
  • Dorsch M, Zheng G, Yowe D, Rao P, Wang Y, Shen Q, Murphy C, Xiong X, Shi Q, Gutierrez-Ramos JC, Fraser C, Villeval JL (September 2002). "Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease". Blood. 100 (6): 2046–55. PMID 12200365.
  • Liu ZJ, Shirakawa T, Li Y, Soma A, Oka M, Dotto GP, Fairman RM, Velazquez OC, Herlyn M (January 2003). "Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis". Molecular and Cellular Biology. 23 (1): 14–25. doi:10.1128/MCB.23.1.14-25.2003. PMC 140667. PMID 12482957.
  • Tohda S, Murata-Ohsawa M, Sakano S, Nara N (May 2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". International Journal of Oncology. 22 (5): 1073–9. doi:10.3892/ijo.22.5.1073. PMID 12684674.
  • Shawber CJ, Das I, Francisco E, Kitajewski J (May 2003). "Notch signaling in primary endothelial cells". Annals of the New York Academy of Sciences. 995: 162–70. doi:10.1111/j.1749-6632.2003.tb03219.x. PMID 12814948.
  • Lauret E, Catelain C, Titeux M, Poirault S, Dando JS, Dorsch M, Villeval JL, Groseil A, Vainchenker W, Sainteny F, Bennaceur-Griscelli A (April 2004). "Membrane-bound delta-4 notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential". Leukemia. 18 (4): 788–97. doi:10.1038/sj.leu.2403288. PMID 14990974.
  • Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • McKeane DP, Meyer J, Dobrin SE, Melmed KM, Ekawardhani S, Tracy NA, Lesch KP, Stephan DA (June 2005). "No causative DLL4 mutations in periodic catatonia patients from 15q15 linked families". Schizophrenia Research. 75 (1): 1–3. doi:10.1016/j.schres.2004.07.017. PMID 15820317.
  • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL (October 2005). "Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function". Cancer Research. 65 (19): 8690–7. doi:10.1158/0008-5472.CAN-05-1208. PMID 16204037.
  • Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li JL, Harris AL (August 2006). "Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer". Clinical Cancer Research. 12 (16): 4836–44. doi:10.1158/1078-0432.CCR-06-0285. PMID 16914569.
  • Lefort N, Benne C, Lelièvre JD, Dorival C, Balbo M, Sakano S, Coulombel L, Lévy Y (December 2006). "Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells". Experimental Hematology. 34 (12): 1720–9. doi:10.1016/j.exphem.2006.08.007. PMID 17157169.
  • Fung E, Tang SM, Canner JP, Morishige K, Arboleda-Velasquez JF, Cardoso AA, Carlesso N, Aster JC, Aikawa M (June 2007). "Delta-like 4 induces notch signaling in macrophages: implications for inflammation". Circulation. 115 (23): 2948–56. doi:10.1161/CIRCULATIONAHA.106.675462. PMID 17533181.
  • Hodkinson PS, Elliott PA, Lad Y, McHugh BJ, MacKinnon AC, Haslett C, Sethi T (September 2007). "Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras". The Journal of Biological Chemistry. 282 (39): 28991–9001. doi:10.1074/jbc.M703601200. PMID 17664272.
  • Zang S, Ji C, Qu X, Dong X, Ma D, Ye J, Ma R, Dai J, Guo D (2007). "A study on Notch signaling in human breast cancer". Neoplasma. 54 (4): 304–10. PMID 17822320.
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