ONECUT1: Difference between revisions

Revision as of 14:05, 14 February 2018

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. ^[1]

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

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 {{Infobox_gene}}
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 ==Function==
-This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
+This gene encodes a member of the Cut homeobox family of [[Transcription factor|transcription factors]]. [[Gene expression|Expression]] of the encoded protein is enriched in the [[liver]], where it stimulates [[Transcription (biology)|transcription]] of liver-expressed genes, and antagonizes [[glucocorticoid]]-stimulated gene transcription. This gene may influence a variety of cellular processes including [[glucose metabolism]], [[Cell-cycle regulation|cell cycle regulation]], and it may also be associated with [[cancer]]. [[Alternative splicing]] results in multiple transcript variants.
 == References ==