Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11gene.[1][2]
This gene encodes an alpha integrin. Integrins are heterodimeric integral membraneproteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.[2]
According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.[3]
References
↑Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, Liu D, Wang SX, Morris CM, Krissansen GW (Nov 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics. 60 (2): 179–87. doi:10.1006/geno.1999.5909. PMID10486209.
Leomil Coelho LF, Mota BE, Sales PC, et al. (2006). "Integrin alpha 11 is a novel type I interferon stimulated gene". Cytokine. 33 (6): 352–61. doi:10.1016/j.cyto.2006.03.007. PMID16697656.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID15146197.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Zhang WM, Kapyla J, Puranen JS, et al. (2003). "alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens". J. Biol. Chem. 278 (9): 7270–7. doi:10.1074/jbc.M210313200. PMID12496264.
Zhang WM, Popova SN, Bergman C, et al. (2003). "Analysis of the human integrin alpha11 gene (ITGA11) and its promoter". Matrix Biol. 21 (6): 513–23. doi:10.1016/S0945-053X(02)00054-9. PMID12392762.
Tiger CF, Fougerousse F, Grundström G, et al. (2001). "alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells". Dev. Biol. 237 (1): 116–29. doi:10.1006/dbio.2001.0363. PMID11518510.
Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D (1999). "cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". J. Biol. Chem. 274 (36): 25735–42. doi:10.1074/jbc.274.36.25735. PMID10464311.
