Sandbox:Maneesha: Difference between revisions
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*The annual incidence of Pleomorphic adenoma is approximately 2-3.5 cases per 100,000 population.<ref name="pmid">{{cite journal |vauthors=Pinkston JA, Cole P |title=Incidence rates of salivary gland tumors: results from a population-based study |journal=Otolaryngol Head Neck Surg |volume=120 |issue=6 |pages=834–40 |date=June 1999 |pmid= |doi=10.1016/S0194-5998(99)70323-2 |url=}}</ref> | *The annual incidence of Pleomorphic adenoma is approximately 2-3.5 cases per 100,000 population.<ref name="pmid">{{cite journal |vauthors=Pinkston JA, Cole P |title=Incidence rates of salivary gland tumors: results from a population-based study |journal=Otolaryngol Head Neck Surg |volume=120 |issue=6 |pages=834–40 |date=June 1999 |pmid= |doi=10.1016/S0194-5998(99)70323-2 |url=}}</ref> | ||
*It accounts for 45-75% of all salivary gland neoplasms. | *It accounts for 45-75% of all salivary gland neoplasms. | ||
===Age=== | *Pleomorphic adenoma distribution among the salivary glands is as follows<ref name="pmid27040584">{{cite journal |vauthors=Zhan KY, Khaja SF, Flack AB, Day TA |title=Benign Parotid Tumors |journal=Otolaryngol. Clin. North Am. |volume=49 |issue=2 |pages=327–42 |date=April 2016 |pmid=27040584 |doi=10.1016/j.otc.2015.10.005 |url=}}</ref>: | ||
**Parotid gland: 84% | |||
**Submandibular gland: 8% | |||
**Minor salivary glands: 6.5% | |||
==Age=== | |||
*People of all age groups may develop Pleomorphic adenoma.<ref name="pmid">{{cite journal |vauthors=Pinkston JA, Cole P |title=Incidence rates of salivary gland tumors: results from a population-based study |journal=Otolaryngol Head Neck Surg |volume=120 |issue=6 |pages=834–40 |date=June 1999 |pmid= |doi=10.1016/S0194-5998(99)70323-2 |url=}}</ref> | *People of all age groups may develop Pleomorphic adenoma.<ref name="pmid">{{cite journal |vauthors=Pinkston JA, Cole P |title=Incidence rates of salivary gland tumors: results from a population-based study |journal=Otolaryngol Head Neck Surg |volume=120 |issue=6 |pages=834–40 |date=June 1999 |pmid= |doi=10.1016/S0194-5998(99)70323-2 |url=}}</ref> | ||
*The incidence of Pleomorphic adenoma increases with age; the average age at diagnosis is 43-46 years. | *The incidence of Pleomorphic adenoma increases with age; the average age at diagnosis is 43-46 years. | ||
===Race=== | ===Race=== | ||
There is no racial predilection to Pleomorphic adenoma. | There is no racial predilection to Pleomorphic adenoma. | ||
| Line 22: | Line 27: | ||
===References | ===References=== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:18, 9 January 2019
Epidemiology and Demographics
Incidence
- The annual incidence of Pleomorphic adenoma is approximately 2-3.5 cases per 100,000 population.[1]
- It accounts for 45-75% of all salivary gland neoplasms.
- Pleomorphic adenoma distribution among the salivary glands is as follows[2]:
- Parotid gland: 84%
- Submandibular gland: 8%
- Minor salivary glands: 6.5%
Age=
- People of all age groups may develop Pleomorphic adenoma.[1]
- The incidence of Pleomorphic adenoma increases with age; the average age at diagnosis is 43-46 years.
Race
There is no racial predilection to Pleomorphic adenoma.
Gender
- Females are predominantly affected by Pleomorphic adenoma than males. The female to male ratio is approximately (2:1)
Causes
- The exact causes of Pleomorphic adenoma are unknown but the tumor has been found to increase 15-20 years after radiation exposure.
- Simian virus(SV40) may play a role in the development of Pleomorphic adenoma.[3]
Risk factors
Prior head and neck irradiation is a risk factor for the development of Pleomorphic adenoma.[4]
References
- ↑ 1.0 1.1 Pinkston JA, Cole P (June 1999). "Incidence rates of salivary gland tumors: results from a population-based study". Otolaryngol Head Neck Surg. 120 (6): 834–40. doi:10.1016/S0194-5998(99)70323-2.
- ↑ Zhan KY, Khaja SF, Flack AB, Day TA (April 2016). "Benign Parotid Tumors". Otolaryngol. Clin. North Am. 49 (2): 327–42. doi:10.1016/j.otc.2015.10.005. PMID 27040584.
- ↑ Martinelli M, Martini F, Rinaldi E, Caramanico L, Magri E, Grandi E, Carinci F, Pastore A, Tognon M (October 2002). "Simian virus 40 sequences and expression of the viral large T antigen oncoprotein in human pleomorphic adenomas of parotid glands". Am. J. Pathol. 161 (4): 1127–33. doi:10.1016/S0002-9440(10)64389-1. PMC 1867276. PMID 12368186.
- ↑ Gündüz AK, Yeşiltaş YS, Shields CL (September 2018). "Overview of benign and malignant lacrimal gland tumors". Curr Opin Ophthalmol. 29 (5): 458–468. doi:10.1097/ICU.0000000000000515. PMID 30028745.