Burkitt's lymphoma classification: Difference between revisions
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It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or [[immunophenotype]]. | It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or [[immunophenotype]]. | ||
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|+ '''Classification Based on The Geographic Distribution and Clinical Presentation''' | |+ '''Classification Based on The Geographic Distribution and Clinical Presentation''' | ||
! style="background: #4479BA;; color:#FFF;" | Name | ! style="background: #4479BA;; color:#FFF;" | Name | ||
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(African Burkitt's lymphoma) | (African Burkitt's lymphoma) | ||
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*The endemic form always presents as a jaw or facial bone tumor | *The endemic form always presents as a jaw or facial bone [[tumor]] | ||
*Primary involvement of the abdomen is not very common | *Primary involvement of the abdomen is not very common | ||
*The primary tumor can disseminate to the extranodal sites such as the mesentery, ovary, testis, kidney, breast, and meninges | *The primary tumor can disseminate to the extranodal sites such as the mesentery, ovary, testis, kidney, breast, and meninges | ||
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* The most common type of Burkitt's lymphoma in North America and Europe | * The most common type of Burkitt's lymphoma in North America and Europe | ||
* Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present | * Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present | ||
* [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood lymphoma | * [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood [[lymphoma]] | ||
*This form usually has an abdominal presentation, most often with massive dissemination and ascites; the distal ileum, stomach , cecum and/or mesentery, kidney, testis, ovary, breast, bone marrow, or central nervous system (CNS) are involved | *This form usually has an abdominal presentation, most often with massive dissemination and [[ascites]]; the distal ileum, stomach , cecum and/or mesentery, kidney, testis, ovary, breast, bone marrow, or central nervous system (CNS) are involved | ||
*Presenting symptoms can be those that are like bowel obstruction or gastrointestinal bleeding, often disguised as acute appendicitis or intussusception | *Presenting symptoms can be those that are like [[bowel obstruction]] or [[gastrointestinal bleeding]], often disguised as [[Appendicitis|acute appendicitis]] or [[intussusception]] | ||
*Almost 25 percent of cases will have presentation of the disease in the jaw or facial bones | *Almost 25 percent of cases will have presentation of the disease in the jaw or facial bones | ||
*Lymphadenopathy, is generally localized | *[[Lymphadenopathy]], is generally localized | ||
*Bone marrow and CNS involvement occurs in about 30 and 15 percent of cases, respectively, but are likely complications of recurrent or treatment resistant disease | *Bone marrow and CNS involvement occurs in about 30 and 15 percent of cases, respectively, but are likely complications of recurrent or treatment resistant disease | ||
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*The presentation of patients with immunodeficiency-related Burkitt's lymphoma is often accompanied by signs or symptoms related to the underlying immunodeficiency which can be the following: | *The presentation of patients with immunodeficiency-related Burkitt's lymphoma is often accompanied by signs or symptoms related to the underlying immunodeficiency which can be the following: | ||
**AIDS | **[[HIV AIDS|AIDS]] | ||
**Congenital immunodeficiency | **[[Primary immunodeficiency|Congenital immunodeficiency]] | ||
**Acquired immunodeficiency due to bone marrow or solid organ transplantation | **Acquired immunodeficiency due to bone marrow or solid [[Organ transplant|organ transplantation]] | ||
*Immunodeficiency-related cases frequently often involve lymph nodes, bone marrow, and CNS | *Immunodeficiency-related cases frequently often involve lymph nodes, bone marrow, and CNS | ||
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Revision as of 14:46, 9 January 2019
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Burkitt's lymphoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Burkitt's lymphoma classification On the Web |
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American Roentgen Ray Society Images of Burkitt's lymphoma classification |
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Risk calculators and risk factors for Burkitt's lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants: endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.
Classification
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants:
- Endemic Burkitt's lymphoma [1]
- Sporadic Burkitt's lymphoma[2]
- Immunodeficiency-associated Burkitt's lymphoma[3]
It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or immunophenotype.
| Name | Description |
|---|---|
| Endemic Burkitt's lymphoma
(African Burkitt's lymphoma) |
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| Sporadic Burkitt's lymphoma
(Non-African or Non-endemic Burkitt's lymphoma) |
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| Immunodeficiency-associated Burkitt's lymphoma |
|
References
- ↑ Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF (1998). "Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue". Blood. 91 (4): 1373–81. PMID 9454768.
- ↑ Ng JY, Thompson RJ, Lam A, Nigam S (2018). "Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-224333. PMID 30042102.
- ↑ Linke-Serinsöz E, Fend F, Quintanilla-Martinez L (2017). "Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point". Semin Diagn Pathol. 34 (4): 352–363. doi:10.1053/j.semdp.2017.04.003. PMID 28506687.