Burkitt's lymphoma classification: Difference between revisions
Jump to navigation
Jump to search
Kamal Akbar (talk | contribs) No edit summary |
Kamal Akbar (talk | contribs) No edit summary |
||
| Line 18: | Line 18: | ||
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Endemic Burkitt's lymphoma''' | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Endemic Burkitt's lymphoma''' | ||
(African Burkitt's lymphoma) | (African Burkitt's lymphoma) | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*The endemic form always presents as a jaw or facial bone [[tumor]] | *The endemic form always presents as a jaw or facial bone [[tumor]] | ||
*Primary involvement of the abdomen is not very common | *Primary involvement of the abdomen is not very common | ||
*The primary tumor can disseminate to the extranodal sites such as the mesentery, ovary, testis, kidney, breast, and meninges | *The primary tumor can disseminate to the extranodal sites such as the [[mesentery]], [[ovary]], [[Testicle|testis]], [[Kidney CA|kidney]], [[breast]], and [[meninges]] | ||
*Peripheral lymph nodes, mediastinum, and spleen involvement are uncommon | *Peripheral [[Lymph node|lymph nodes]], [[mediastinum]], and [[spleen]] involvement are uncommon | ||
*Bone marrow involvement is noted in less than 10 percent of patients at the time of initial diagnosis but is a common complication of treatment resistant disease. | *[[Bone marrow]] involvement is noted in less than 10 percent of patients at the time of initial diagnosis but is a common complication of treatment resistant disease. | ||
|- | |- | ||
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Sporadic Burkitt's lymphoma''' | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | '''Sporadic Burkitt's lymphoma''' | ||
| Line 31: | Line 31: | ||
* Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present | * Sometimes associated with the [[Epstein-Barr virus]], but in many cases this virus is not present | ||
* [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood [[lymphoma]] | * [[Non-Hodgkin's lymphoma]], which includes Burkitt's, accounts for 30-50% of childhood [[lymphoma]] | ||
*This form usually has an abdominal presentation, most often with massive dissemination and [[ascites]]; the distal ileum, stomach , cecum and/or mesentery, kidney, testis, ovary, breast, bone marrow, or central nervous system (CNS) are involved | *This form usually has an abdominal presentation, most often with massive dissemination and [[ascites]]; the distal [[ileum]], [[stomach]] , [[cecum]] and/or mesentery, kidney, testis, ovary, breast, bone marrow, or [[Central nervous system|central nervous system (CNS)]] are involved | ||
*Presenting symptoms can be those that are like [[bowel obstruction]] or [[gastrointestinal bleeding]], often disguised as [[Appendicitis|acute appendicitis]] or [[intussusception]] | *Presenting symptoms can be those that are like [[bowel obstruction]] or [[gastrointestinal bleeding]], often disguised as [[Appendicitis|acute appendicitis]] or [[intussusception]] | ||
*Almost 25 percent of cases will have presentation of the disease in the jaw or facial bones | *Almost 25 percent of cases will have presentation of the disease in the [[jaw]] or [[facial bones]] | ||
*[[Lymphadenopathy]], is generally localized | *[[Lymphadenopathy]], is generally localized | ||
*Bone marrow and CNS involvement occurs in about 30 and 15 percent of cases, respectively, but are likely complications of recurrent or treatment resistant disease | *Bone marrow and CNS involvement occurs in about 30 and 15 percent of cases, respectively, but are likely complications of recurrent or treatment resistant disease | ||
Revision as of 14:50, 9 January 2019
|
Burkitt's lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Burkitt's lymphoma classification On the Web |
|
American Roentgen Ray Society Images of Burkitt's lymphoma classification |
|
Risk calculators and risk factors for Burkitt's lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants: endemic Burkitt's lymphoma, sporadic Burkitt's lymphoma, and immunodeficiency-associated Burkitt's lymphoma.
Classification
Burkitt's lymphoma may be classified according to WHO classification into 3 clinical variants:
- Endemic Burkitt's lymphoma [1]
- Sporadic Burkitt's lymphoma[2]
- Immunodeficiency-associated Burkitt's lymphoma[3]
It is almost impossible to differentiate these three clinical variants based on histology (i.e. microscopic appearance) or immunophenotype.
| Name | Description |
|---|---|
| Endemic Burkitt's lymphoma
(African Burkitt's lymphoma) |
|
| Sporadic Burkitt's lymphoma
(Non-African or Non-endemic Burkitt's lymphoma) |
|
| Immunodeficiency-associated Burkitt's lymphoma |
|
References
- ↑ Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF (1998). "Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue". Blood. 91 (4): 1373–81. PMID 9454768.
- ↑ Ng JY, Thompson RJ, Lam A, Nigam S (2018). "Sporadic Burkitt's lymphoma masquerading as an intussuscepted Meckel's diverticulum in a 9-year-old child". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-224333. PMID 30042102.
- ↑ Linke-Serinsöz E, Fend F, Quintanilla-Martinez L (2017). "Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point". Semin Diagn Pathol. 34 (4): 352–363. doi:10.1053/j.semdp.2017.04.003. PMID 28506687.