Enteropathy-associated T-cell lymphoma CT: Difference between revisions
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===CT scan | ==Overview== | ||
Enteropathy-associated T-cell Lymphoma (EATL), also enteropathy-type T-cell lymphoma (ETTL), is a type of T-cell non-hodgkin lymphoma that affects the small intestine, it is composed of large lymphoid cells. Enteropathy-associated T-cell lymphoma has two subtypes, type I enteropathy-associated T-cell lymphoma which has a strong association with celiac disease and it is more common in western countries and type II enteropathy-associated T-cell lymphoma which is mostly found among the Asian population. Genes involved in the pathogenesis of this disease include 8q24, T-cell receptor (TCR) beta and gamma, and 16q genes. On gross pathology, multiple intestinal ulcers are characteristic findings of EATL. On microscopic histopathological analysis, monotonous cells, round or angulated vesicular nuclei, and prominent nucleoli are characteristic findings of enteropathy-associated T-cell lymphoma. There are no established causes for enteropathy-associated T-cell lymphoma. EATL must be differentiated from other diseases such as peptic ulcer, poorly-differentiated adenocarcinoma, MALT lymphoma, diffuse large B cell lymphoma, and mantle cell lymphoma. | |||
==CT scan== | |||
* [[CT scan]] may be helpful in the diagnosis of enteropathy-associated T-cell lymphoma.<ref name="cancer.gov">Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016</ref> | * [[CT scan]] may be helpful in the diagnosis of enteropathy-associated T-cell lymphoma.<ref name="cancer.gov">Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016</ref> | ||
* Findings on [[CT]] scan suggestive of enteropathy-associated T-cell lymphoma include:<ref name="LeeIm2003">{{cite journal|last1=Lee|first1=Hyun Ju|last2=Im|first2=Jung-Gi|last3=Goo|first3=Jin Mo|last4=Kim|first4=Kyoung Won|last5=Choi|first5=Byung Ihn|last6=Chang|first6=Kee Hyun|last7=Han|first7=Joon Koo|last8=Han|first8=Moon Hee|title=Peripheral T-Cell Lymphoma: Spectrum of Imaging Findings with Clinical and Pathologic Features1|journal=RadioGraphics|volume=23|issue=1|year=2003|pages=7–26|issn=0271-5333|doi=10.1148/rg.231025018}}. Accessed on January 28, 2016</ref><ref name="Di SabatinoBiagi2012">{{cite journal|last1=Di Sabatino|first1=A.|last2=Biagi|first2=F.|last3=Gobbi|first3=P. G.|last4=Corazza|first4=G. R.|title=How I treat enteropathy-associated T-cell lymphoma|journal=Blood|volume=119|issue=11|year=2012|pages=2458–2468|issn=0006-4971|doi=10.1182/blood-2011-10-385559}}. Accessed on January 28, 2016</ref> | * Findings on [[CT]] scan suggestive of enteropathy-associated T-cell lymphoma include:<ref name="LeeIm2003">{{cite journal|last1=Lee|first1=Hyun Ju|last2=Im|first2=Jung-Gi|last3=Goo|first3=Jin Mo|last4=Kim|first4=Kyoung Won|last5=Choi|first5=Byung Ihn|last6=Chang|first6=Kee Hyun|last7=Han|first7=Joon Koo|last8=Han|first8=Moon Hee|title=Peripheral T-Cell Lymphoma: Spectrum of Imaging Findings with Clinical and Pathologic Features1|journal=RadioGraphics|volume=23|issue=1|year=2003|pages=7–26|issn=0271-5333|doi=10.1148/rg.231025018}}. Accessed on January 28, 2016</ref><ref name="Di SabatinoBiagi2012">{{cite journal|last1=Di Sabatino|first1=A.|last2=Biagi|first2=F.|last3=Gobbi|first3=P. G.|last4=Corazza|first4=G. R.|title=How I treat enteropathy-associated T-cell lymphoma|journal=Blood|volume=119|issue=11|year=2012|pages=2458–2468|issn=0006-4971|doi=10.1182/blood-2011-10-385559}}. Accessed on January 28, 2016</ref> | ||
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:* [[Intussusception]] | :* [[Intussusception]] | ||
:* Small-sized [[spleen]] | :* Small-sized [[spleen]] | ||
==Refrences== | ==Refrences== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:26, 9 January 2019
Overview
Enteropathy-associated T-cell Lymphoma (EATL), also enteropathy-type T-cell lymphoma (ETTL), is a type of T-cell non-hodgkin lymphoma that affects the small intestine, it is composed of large lymphoid cells. Enteropathy-associated T-cell lymphoma has two subtypes, type I enteropathy-associated T-cell lymphoma which has a strong association with celiac disease and it is more common in western countries and type II enteropathy-associated T-cell lymphoma which is mostly found among the Asian population. Genes involved in the pathogenesis of this disease include 8q24, T-cell receptor (TCR) beta and gamma, and 16q genes. On gross pathology, multiple intestinal ulcers are characteristic findings of EATL. On microscopic histopathological analysis, monotonous cells, round or angulated vesicular nuclei, and prominent nucleoli are characteristic findings of enteropathy-associated T-cell lymphoma. There are no established causes for enteropathy-associated T-cell lymphoma. EATL must be differentiated from other diseases such as peptic ulcer, poorly-differentiated adenocarcinoma, MALT lymphoma, diffuse large B cell lymphoma, and mantle cell lymphoma.
CT scan
- CT scan may be helpful in the diagnosis of enteropathy-associated T-cell lymphoma.[1]
- Findings on CT scan suggestive of enteropathy-associated T-cell lymphoma include:[2][3]
- Bowel wall thickening
- Mesenteric fat infiltration
- Mesenteric lymph node cavitation
- Intussusception
- Small-sized spleen
Refrences
- ↑ Enteropathy-associated T-cell lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd5315/. Accessed on January 26, 2016
- ↑ Lee, Hyun Ju; Im, Jung-Gi; Goo, Jin Mo; Kim, Kyoung Won; Choi, Byung Ihn; Chang, Kee Hyun; Han, Joon Koo; Han, Moon Hee (2003). "Peripheral T-Cell Lymphoma: Spectrum of Imaging Findings with Clinical and Pathologic Features1". RadioGraphics. 23 (1): 7–26. doi:10.1148/rg.231025018. ISSN 0271-5333.. Accessed on January 28, 2016
- ↑ Di Sabatino, A.; Biagi, F.; Gobbi, P. G.; Corazza, G. R. (2012). "How I treat enteropathy-associated T-cell lymphoma". Blood. 119 (11): 2458–2468. doi:10.1182/blood-2011-10-385559. ISSN 0006-4971.. Accessed on January 28, 2016