'''Feline leukemia virus subgroup C cellular receptor family, member 2''' is a [[protein]] that in humans is encoded by the FLVCR2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Feline leukemia virus subgroup C cellular receptor family, member 2 }}</ref>
'''Feline leukemia virus subgroup C cellular receptor family, member 2''' is a [[protein]] that in humans is encoded by the FLVCR2 [[gene]].<ref name="entrez">{{cite web |url=https://www.ncbi.nlm.nih.gov/gene/55640| website=NCBI|title = Entrez Gene: Feline leukemia virus subgroup C cellular receptor family, member 2 }}</ref>
Feline leukemia virus subgroup C cellular receptor family, member 2 is a protein that in humans is encoded by the FLVCR2 gene.[1]
Function
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1 (FLVCR1), the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome.
Thomas S, Encha-Razavi F, Devisme L, Etchevers H, Bessieres-Grattagliano B, Goudefroye G, Elkhartoufi N, Pateau E, Ichkou A, Bonnière M, Marcorelle P, Parent P, Manouvrier S, Holder M, Laquerrière A, Loeuillet L, Roume J, Martinovic J, Mougou-Zerelli S, Gonzales M, Meyer V, Wessner M, Feysot CB, Nitschke P, Leticee N, Munnich A, Lyonnet S, Wookey P, Gyapay G, Foliguet B, Vekemans M, Attié-Bitach T (Oct 2010). "High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy". Human Mutation. 31 (10): 1134–41. doi:10.1002/humu.21329. PMID20690116.
