RGS6: Difference between revisions
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*{{cite journal |vauthors=Sherrington R, Rogaev EI, Liang Y, etal |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease |journal=Nature |volume=375 |issue= 6534 |pages= 754–60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0 }} | *{{cite journal |vauthors=Sherrington R, Rogaev EI, Liang Y, etal |title=Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease |journal=Nature |volume=375 |issue= 6534 |pages= 754–60 |year= 1995 |pmid= 7596406 |doi= 10.1038/375754a0 |bibcode=1995Natur.375..754S }} | ||
*{{cite journal |vauthors=Snow BE, Betts L, Mangion J, etal |title=Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6489–94 |year= 1999 |pmid= 10339615 |doi=10.1073/pnas.96.11.6489 | pmc=26909 }} | *{{cite journal |vauthors=Snow BE, Betts L, Mangion J, etal |title=Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6489–94 |year= 1999 |pmid= 10339615 |doi=10.1073/pnas.96.11.6489 | pmc=26909 |bibcode=1999PNAS...96.6489S }} | ||
*{{cite journal |vauthors=Posner BA, Gilman AG, Harris BA |title=Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31087–93 |year= 1999 |pmid= 10521509 |doi=10.1074/jbc.274.43.31087 }} | *{{cite journal |vauthors=Posner BA, Gilman AG, Harris BA |title=Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 31087–93 |year= 1999 |pmid= 10521509 |doi=10.1074/jbc.274.43.31087 }} | ||
*{{cite journal |vauthors=Liu Z, Chatterjee TK, Fisher RA |title=RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37832–9 |year= 2002 |pmid= 12140291 |doi= 10.1074/jbc.M205908200 }} | *{{cite journal |vauthors=Liu Z, Chatterjee TK, Fisher RA |title=RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37832–9 |year= 2002 |pmid= 12140291 |doi= 10.1074/jbc.M205908200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Chatterjee TK, Fisher RA |title=Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30272–82 |year= 2003 |pmid= 12761220 |doi= 10.1074/jbc.M212688200 }} | *{{cite journal |vauthors=Chatterjee TK, Fisher RA |title=Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30272–82 |year= 2003 |pmid= 12761220 |doi= 10.1074/jbc.M212688200 }} | ||
*{{cite journal |vauthors=Chatterjee TK, Liu Z, Fisher RA |title=Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30261–71 |year= 2003 |pmid= 12761221 |doi= 10.1074/jbc.M212687200 }} | *{{cite journal |vauthors=Chatterjee TK, Liu Z, Fisher RA |title=Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30261–71 |year= 2003 |pmid= 12761221 |doi= 10.1074/jbc.M212687200 }} | ||
Revision as of 01:41, 26 June 2018
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Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.[1][2][3]
Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM][3]
Interactions
RGS6 has been shown to interact with STMN2[4] and DMAP1.[2]
References
- ↑ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". J Hum Genet. 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744.
- ↑ 2.0 2.1 Liu Z, Fisher RA (March 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". J Biol Chem. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.
- ↑ 3.0 3.1 "Entrez Gene: RGS6 regulator of G-protein signalling 6".
- ↑ Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. United States. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291.
Further reading
- Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406.
- Snow BE, Betts L, Mangion J, et al. (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
- Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
- Liu Z, Chatterjee TK, Fisher RA (2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chatterjee TK, Fisher RA (2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins". J. Biol. Chem. 278 (32): 30272–82. doi:10.1074/jbc.M212688200. PMID 12761220.
- Chatterjee TK, Liu Z, Fisher RA (2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
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