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*{{cite journal | vauthors=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403–7 |year= 1992 |pmid= 1741396 |doi=10.1073/pnas.89.4.1403 | pmc=48459 }} | *{{cite journal | vauthors=Takagaki Y, MacDonald CC, Shenk T, Manley JL |title=The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1403–7 |year= 1992 |pmid= 1741396 |doi=10.1073/pnas.89.4.1403 | pmc=48459 |bibcode=1992PNAS...89.1403T }} | ||
*{{cite journal | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672 }} | *{{cite journal | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672 }} | ||
*{{cite journal | vauthors=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 }} | *{{cite journal | vauthors=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 |bibcode=1994Natur.372..471T }} | ||
*{{cite journal | vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107 }} | *{{cite journal | vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107 }} | ||
*{{cite journal | vauthors=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=10.1126/science.285.5433.1576 }} | *{{cite journal | vauthors=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=10.1126/science.285.5433.1576 }} | ||
*{{cite journal | vauthors=Takagaki Y, Manley JL |title=Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000 | pmc=85326 }} | *{{cite journal | vauthors=Takagaki Y, Manley JL |title=Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000 | pmc=85326 }} | ||
*{{cite journal | vauthors=Fong N, Bentley DL |title=Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD |journal=Genes Dev. |volume=15 |issue= 14 |pages= 1783–95 |year= 2001 |pmid= 11459828 |doi= 10.1101/gad.889101 | pmc=312735 }} | *{{cite journal | vauthors=Fong N, Bentley DL |title=Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD |journal=Genes Dev. |volume=15 |issue= 14 |pages= 1783–95 |year= 2001 |pmid= 11459828 |doi= 10.1101/gad.889101 | pmc=312735 }} | ||
*{{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}} | *{{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal|bibcode=2001Natur.414..865D }} | ||
*{{cite journal | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}} | *{{cite journal | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}} | ||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}} | *{{cite journal | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}} | ||
Revision as of 01:26, 23 June 2018
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Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.[1][2][3]
This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[3]
Interactions
CSTF1 has been shown to interact with BARD1.[2][4]
References
- ↑ Takagaki Y, Manley JL (Dec 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". J Biol Chem. 267 (33): 23471–4. PMID 1358884.
- ↑ 2.0 2.1 Kleiman FE, Manley JL (Mar 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228.
- ↑ 3.0 3.1 "Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".
- ↑ Kleiman, F E; Manley J L (Sep 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. UNITED STATES. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523.
External links
- Human CSTF1 genome location and CSTF1 gene details page in the UCSC Genome Browser.
Further reading
- Takagaki Y, MacDonald CC, Shenk T, Manley JL (1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1403–7. Bibcode:1992PNAS...89.1403T. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
- Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
- Takagaki Y, Manley JL (1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4. Bibcode:1994Natur.372..471T. doi:10.1038/372471a0. PMID 7984242.
- Rüegsegger U, Beyer K, Keller W (1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". J. Biol. Chem. 271 (11): 6107–13. doi:10.1074/jbc.271.11.6107. PMID 8626397.
- Kleiman FE, Manley JL (1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. PMID 10477523.
- Takagaki Y, Manley JL (2000). "Complex Protein Interactions within the Human Polyadenylation Machinery Identify a Novel Component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
- Fong N, Bentley DL (2001). "Capping, splicing, and 3′ processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD". Genes Dev. 15 (14): 1783–95. doi:10.1101/gad.889101. PMC 312735. PMID 11459828.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Tsuzuki M, Wu W, Nishikawa H, et al. (2006). "A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats". Cancer Lett. 233 (1): 108–16. doi:10.1016/j.canlet.2005.03.012. PMID 15878232.
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