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{{Infobox gene}}
{{Infobox gene}}
'''MicroRNA 7-1''' is a [[protein]] that in humans is encoded by the MIR7-1 [[gene]].<ref name="entrez">{{cite web
| title = Entrez Gene: MicroRNA 7-1 | url = https://www.ncbi.nlm.nih.gov/gene/407043 | work = [[National Center for Biotechnology Information]] | publisher = [[National Institutes of Health]] | accessdate = 26 December 2013 }}</ref>


'''MicroRNA 7-1''' is a [[protein]] that in humans is encoded by the MIR7-1 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: MicroRNA 7-1
| url = https://www.ncbi.nlm.nih.gov/gene/407043
| work = [[National Center for Biotechnology Information]]
| publisher = [[National Institutes of Health]]
| accessdate = 26 December 2013
}}</ref>
 
==Function==
{{technical|date=January 2014}}
{{technical|date=January 2014}}
[[microRNAs]], or miRNAs, are short (20-24 [[nucleotide|nt]]) non-coding [[RNA]]s that are involved in post-transcriptional regulation of gene expression in [[multicellular organism]]s by affecting both the stability and translation of mRNAs. miRNAs are transcribed by [[RNA polymerase II]] as part of capped and [[polyadenylation|polyadenylated]] [[primary transcript]]s (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III [[enzyme]] to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and [[Antisense RNA|antisense]] miRNA star (miRNA*) products. The mature miRNA is incorporated into a [[RNA-induced silencing complex]] (RISC), which recognizes target mRNAs through imperfect [[base pairing]] with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The [[RefSeq]] represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
[[microRNAs]], or miRNAs, are short (20-24 [[nucleotide|nt]]) non-coding [[RNA]]s that are involved in post-transcriptional regulation of gene expression in [[multicellular organism]]s by affecting both the stability and translation of mRNAs. miRNAs are transcribed by [[RNA polymerase II]] as part of capped and [[polyadenylation|polyadenylated]] [[primary transcript]]s (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III [[enzyme]] to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and [[Antisense RNA|antisense]] miRNA star (miRNA*) products. The mature miRNA is incorporated into a [[RNA-induced silencing complex]] (RISC), which recognizes target mRNAs through imperfect [[base pairing]] with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The [[RefSeq]] represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal  
* {{cite journal | vauthors = Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP | title = Vertebrate microRNA genes | journal = Science | volume = 299 | issue = 5612 | pages = 1540 | date = March 2003 | pmid = 12624257 | pmc = | doi = 10.1126/science.1080372 }}
| last1 = Lim | first1 = L. P.
* {{cite journal | vauthors = Correa-Medina M, Bravo-Egana V, Rosero S, Ricordi C, Edlund H, Diez J, Pastori RL | title = MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas | journal = Gene Expression Patterns | volume = 9 | issue = 4 | pages = 193–9 | date = April 2009 | pmid = 19135553 | pmc = | doi = 10.1016/j.gep.2008.12.003 }}
| last2 = Glasner | first2 = M. E.
* {{cite journal | vauthors = Chen AX, Yu KD, Fan L, Li JY, Yang C, Huang AJ, Shao ZM | title = Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility | journal = PLoS Genetics | volume = 7 | issue = 9 | pages = e1002259 | date = September 2011 | pmid = 21912531 | pmc = 3164678 | doi = 10.1371/journal.pgen.1002259 | editor1-last = Horwitz | editor1-first = Marshall S }}
| last3 = Yekta | first3 = S.
* {{cite journal | vauthors = Xu L, Wen Z, Zhou Y, Liu Z, Li Q, Fei G, Luo J, Ren T | title = MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway | journal = Molecular Biology of the Cell | volume = 24 | issue = 1 | pages = 42–55 | date = January 2013 | pmid = 23135998 | pmc = 3530778 | doi = 10.1091/mbc.E12-07-0519 }}
| last4 = Burge | first4 = C. B.
* {{cite journal | vauthors = Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B | title = microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma | journal = Cancer Research | volume = 68 | issue = 10 | pages = 3566–72 | date = May 2008 | pmid = 18483236 | pmc = | doi = 10.1158/0008-5472.CAN-07-6639 }}
| last5 = Bartel | first5 = D. P.
* {{cite journal | vauthors = Bravo-Egana V, Rosero S, Molano RD, Pileggi A, Ricordi C, Domínguez-Bendala J, Pastori RL | title = Quantitative differential expression analysis reveals miR-7 as major islet microRNA | journal = Biochemical and Biophysical Research Communications | volume = 366 | issue = 4 | pages = 922–6 | date = February 2008 | pmid = 18086561 | pmc = 4104201 | doi = 10.1016/j.bbrc.2007.12.052 }}
| title = Vertebrate MicroRNA Genes
* {{cite journal | vauthors = Chen ZX, Sun AM, Chen Y, Liu Y, Zhan JF, Chen LH, Yuan YW | title = [Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma] | journal = Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University | volume = 30 | issue = 8 | pages = 1810–2, 1816 | date = August 2010 | pmid = 20813671 }}
| doi = 10.1126/science.1080372
* {{cite journal | vauthors = Kredo-Russo S, Ness A, Mandelbaum AD, Walker MD, Hornstein E | title = Regulation of pancreatic microRNA-7 expression | journal = Experimental Diabetes Research | volume = 2012 | pages = 695214 | year = 2012 | pmid = 22675342 | pmc = 3362837 | doi = 10.1155/2012/695214 }}
| journal = Science  
* {{cite journal | vauthors = Wang Y, Liu J, Liu C, Naji A, Stoffers DA | title = MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells | journal = Diabetes | volume = 62 | issue = 3 | pages = 887–95 | date = March 2013 | pmid = 23223022 | pmc = 3581216 | doi = 10.2337/db12-0451 }}
| volume = 299  
* {{cite journal | vauthors = Midgley AC, Bowen T, Phillips AO, Steadman R | title = MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts | journal = Aging Cell | volume = 13 | issue = 2 | pages = 235–44 | date = April 2014 | pmid = 24134702 | pmc = 4331777 | doi = 10.1111/acel.12167 }}
| issue = 5612  
* {{cite journal | vauthors = Midgley AC, Morris G, Phillips AO, Steadman R | title = 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation | journal = Aging Cell | volume = 15 | issue = 3 | pages = 531–41 | date = June 2016 | pmid = 26931423 | pmc = | doi = 10.1111/acel.12462 }}
| pages = 1540  
| year = 2003  
| pmid = 12624257  
| pmc =  
}}
*{{Cite journal  
| last1 = Correa-Medina | first1 = M.
| last2 = Bravo-Egana | first2 = V.
| last3 = Rosero | first3 = S.
| last4 = Ricordi | first4 = C.
| last5 = Edlund | first5 = H.
| last6 = Diez | first6 = J.
| last7 = Pastori | first7 = R. L.
| doi = 10.1016/j.gep.2008.12.003
| title = MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas  
| journal = Gene Expression Patterns  
| volume = 9  
| issue = 4  
| pages = 193–199
| year = 2009  
| pmid = 19135553  
| pmc =  
}}
*{{Cite journal  
| last1 = Chen | first1 = A. X.
| last2 = Yu | first2 = K. D.
| last3 = Fan | first3 = L.
| last4 = Li | first4 = J. Y.
| last5 = Yang | first5 = C.
| last6 = Huang | first6 = A. J.
| last7 = Shao | first7 = Z. M.
| editor1-last = Horwitz
| editor1-first = Marshall S
| title = Germline Genetic Variants Disturbing the Let-7/LIN28 Double-Negative Feedback Loop Alter Breast Cancer Susceptibility
| doi = 10.1371/journal.pgen.1002259
| journal = PLoS Genetics  
| volume = 7  
| issue = 9  
| pages = e1002259  
| year = 2011  
| pmid = 21912531  
| pmc =3164678  
}}
*{{Cite journal  
| last1 = Xu | first1 = L.
| last2 = Wen | first2 = Z.
| last3 = Zhou | first3 = Y.
| last4 = Liu | first4 = Z.
| last5 = Li | first5 = Q.
| last6 = Fei | first6 = G.
| last7 = Luo | first7 = J.
| last8 = Ren | first8 = T.
| doi = 10.1091/mbc.E12-07-0519
| title = MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3/Akt pathway  
| journal = Molecular Biology of the Cell  
| volume = 24  
| issue = 1  
| pages = 42–55  
| year = 2012
| pmid = 23135998  
| pmc =3530778  
}}
*{{Cite journal  
| last1 = Kefas | first1 = B.
| last2 = Godlewski | first2 = J.
| last3 = Comeau | first3 = L.
| last4 = Li | first4 = Y.
| last5 = Abounader | first5 = R.
| last6 = Hawkinson | first6 = M.
| last7 = Lee | first7 = J.
| last8 = Fine | first8 = H.
| last9 = Chiocca | first9 = E. A.
| last10 = Lawler | first10 = S.
| last11 = Purow | first11 = B.
| doi = 10.1158/0008-5472.CAN-07-6639
| title = MicroRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and is Down-regulated in Glioblastoma
| journal = Cancer Research  
| volume = 68  
| issue = 10  
| pages = 3566–3572
| year = 2008  
| pmid = 18483236  
| pmc =  
}}
*{{Cite journal  
| last1 = Bravo-Egana | first1 = V.
| last2 = Rosero | first2 = S.
| last3 = Molano | first3 = R. D.
| last4 = Pileggi | first4 = A.
| last5 = Ricordi | first5 = C.
| last6 = Domínguez-Bendala | first6 = J.
| last7 = Pastori | first7 = R. L.
| doi = 10.1016/j.bbrc.2007.12.052
| title = Quantitative differential expression analysis reveals miR-7 as major islet microRNA  
| journal = Biochemical and Biophysical Research Communications  
| volume = 366  
| issue = 4  
| pages = 922–926
| year = 2008  
| pmid = 18086561  
| pmc = 4104201
}}
*{{Cite journal  
| last1 = Chen | first1 = Z. X.
| last2 = Sun | first2 = A. M.
| last3 = Chen | first3 = Y.
| last4 = Liu | first4 = Y.
| last5 = Zhan | first5 = J. F.
| last6 = Chen | first6 = L. H.
| last7 = Yuan | first7 = Y. W.
| title = Effects of radiosensitivity and X-ray dose on miR-7 expression in nasopharyngeal carcinoma  
| journal = Nan fang yi ke da xue xue bao = Journal of Southern Medical University  
| volume = 30  
| issue = 8  
| pages = 1810–1812, 1816  
| year = 2010  
| pmid = 20813671
}}
*{{Cite journal  
| last1 = Kredo-Russo | first1 = S.
| last2 = Ness | first2 = A.
| last3 = Mandelbaum | first3 = A. D.
| last4 = Walker | first4 = M. D.
| last5 = Hornstein | first5 = E.
| title = Regulation of Pancreatic microRNA-7 Expression
| doi = 10.1155/2012/695214
| journal = Experimental Diabetes Research  
| volume = 2012  
| pages = 1–7
| year = 2012  
| pmid = 22675342  
| pmc =3362837  
}}
*{{Cite journal  
| last1 = Wang | first1 = Y.
| last2 = Liu | first2 = J.
| last3 = Liu | first3 = C.
| last4 = Naji | first4 = A.
| last5 = Stoffers | first5 = D. A.
| title = MicroRNA-7 Regulates the mTOR Pathway and Proliferation in Adult Pancreatic  -Cells
| doi = 10.2337/db12-0451
| journal = Diabetes  
| volume = 62  
| issue = 3  
| pages = 887–895
| year = 2012
| pmid = 23223022  
| pmc =3581216  
}}
*{{Cite journal  
| last1 = Midgley | first1 = A. C.
| last2 = Bowen | first2 = T.
| last3 = Phillips | first3 = A. O.
| last4 = Steadman | first4 = R.
| title = MicroRNA-7 inhibition rescues age-associated loss of EGFR receptor and HA-dependent differentiation in fibroblasts  
| doi = 10.1111/acel.12167
| journal = Aging Cell  
| volume = 13  
| issue = 2  
| pages = 235–44
| year = 2014  
| pmid = 24134702  
| pmc =4331777  
}}
*{{Cite journal  
| last1 = Midgley | first1 = A. C.
| last2 = Morris | first2 = G.
| last3 = Phillips | first3 = A. O.
| last4 = Steadman | first4 = R.
| title = 17β-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-γ/STAT1-dependent miR-7 upregulation  
| doi = 10.1111/acel.12462
| journal = Aging Cell  
| volume = 15
| issue = 3
| pages = 531–41
| year = 2016  
| pmid = 26931423  
| pmc =  
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


[[Category:Human genes]]
[[Category:Human proteins]]
[[Category:Human proteins]]
[[Category:Genes on human chromosome 9]]
[[Category:Genes on human chromosome 9]]


{{gene-9-stub}}
{{gene-9-stub}}

Revision as of 01:54, 25 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MicroRNA 7-1 is a protein that in humans is encoded by the MIR7-1 gene.[1]

Function

microRNAs, or miRNAs, are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

  1. ↑ "Entrez Gene: MicroRNA 7-1". National Center for Biotechnology Information. National Institutes of Health. Retrieved 26 December 2013.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=MIR7-1&oldid=1522640"