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== Clinical significance == | == Clinical significance == | ||
Mutations in ''LRSAM1'' have been reported in the [[peripheral neuropathy]] [[Charcot-Marie-Tooth]] type 2P (OMIM 614436),<ref name="pmid20865121">{{cite journal |vauthors=Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M, Skidmore DL, Benstead T, Samuels ME | title = Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease | journal = PLoS Genet. | volume = 6 | issue = 8 | pages = |date=August 2010 | pmid = 20865121 | pmc = 2928813 | doi = 10.1371/journal.pgen.1001081 }}</ref><ref name="pmid22012984">{{cite journal |vauthors=Weterman MA, Sorrentino V, Kasher PR, Jakobs ME, van Engelen BG, Fluiter K, de Wissel MB, Sizarov A, Nürnberg G, Nürnberg P, Zelcer N, Schelhaas HJ, Baas F | title = A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy | journal = Hum. Mol. Genet. | volume = 21 | issue = 2 | pages = 358–70 |date=January 2012 | pmid = 22012984 | pmc = 3276280 | doi = 10.1093/hmg/ddr471 }}</ref><ref name="pmid22781092">{{cite journal |vauthors=Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E, Middleton L, Christodoulou K | title = A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease | journal = Eur. J. Hum. Genet. | volume = 21 | issue = 2 | pages = 190–4 |date=February 2013 | pmid = 22781092 | doi = 10.1038/ejhg.2012.146 | pmc=3548253}}</ref> while disruption of the mouse ''Lrsam1'' gene has been shown to sensitize peripheral axons to acrylamide-induced degeneration.<ref name="pmid23519028">{{cite journal |vauthors=Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW | title = Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease | journal = Dis Model Mech | volume = 6 | issue = 3 | pages = 780–92 |date=May 2013 | pmid = 23519028 | pmc = 3634660 | doi = 10.1242/dmm.010942 }}</ref> | Mutations in ''LRSAM1'' have been reported in the [[peripheral neuropathy]] [[Charcot-Marie-Tooth]] type 2P (OMIM 614436),<ref name="pmid20865121">{{cite journal |vauthors=Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M, Skidmore DL, Benstead T, Samuels ME | title = Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease | journal = PLoS Genet. | volume = 6 | issue = 8 | pages = e1001081|date=August 2010 | pmid = 20865121 | pmc = 2928813 | doi = 10.1371/journal.pgen.1001081 }}</ref><ref name="pmid22012984">{{cite journal |vauthors=Weterman MA, Sorrentino V, Kasher PR, Jakobs ME, van Engelen BG, Fluiter K, de Wissel MB, Sizarov A, Nürnberg G, Nürnberg P, Zelcer N, Schelhaas HJ, Baas F | title = A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy | journal = Hum. Mol. Genet. | volume = 21 | issue = 2 | pages = 358–70 |date=January 2012 | pmid = 22012984 | pmc = 3276280 | doi = 10.1093/hmg/ddr471 }}</ref><ref name="pmid22781092">{{cite journal |vauthors=Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E, Middleton L, Christodoulou K | title = A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease | journal = Eur. J. Hum. Genet. | volume = 21 | issue = 2 | pages = 190–4 |date=February 2013 | pmid = 22781092 | doi = 10.1038/ejhg.2012.146 | pmc=3548253}}</ref> while disruption of the mouse ''Lrsam1'' gene has been shown to sensitize peripheral axons to acrylamide-induced degeneration.<ref name="pmid23519028">{{cite journal |vauthors=Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW | title = Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease | journal = Dis Model Mech | volume = 6 | issue = 3 | pages = 780–92 |date=May 2013 | pmid = 23519028 | pmc = 3634660 | doi = 10.1242/dmm.010942 }}</ref> | ||
== Interactions == | == Interactions == | ||
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{{refbegin | 2}} | {{refbegin | 2}} | ||
*{{cite journal |vauthors=Mazzé FM, Degrève L |title=The role of viral and cellular proteins in the budding of human immunodeficiency virus |journal=Acta Virol. |volume=50 |issue= 2 |pages= 75–85 |year= 2006 |pmid= 16808324 |doi= }} | *{{cite journal |vauthors=Mazzé FM, Degrève L |title=The role of viral and cellular proteins in the budding of human immunodeficiency virus |journal=Acta Virol. |volume=50 |issue= 2 |pages= 75–85 |year= 2006 |pmid= 16808324 |doi= }} | ||
*{{cite journal | author=Auffray C |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal= | *{{cite journal | author=Auffray C |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi= |name-list-format=vanc| author2=Behar G | author3=Bois F | display-authors=3 | last4=Bouchier | first4=C | last5=Da Silva | first5=C | last6=Devignes | first6=MD | last7=Duprat | first7=S | last8=Houlgatte | first8=R | last9=Jumeau | first9=MN }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Li B |title=RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells |journal=J. Cell. Biochem. |volume=90 |issue= 6 |pages= 1224–41 |year= 2004 |pmid= 14635195 |doi= 10.1002/jcb.10674 |name-list-format=vanc| author2=Su Y | author3=Ryder J | display-authors=3 | last4=Yan | first4=Lei | last5=Na | first5=Songqing | last6=Ni | first6=Binhui }} | *{{cite journal | author=Li B |title=RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells |journal=J. Cell. Biochem. |volume=90 |issue= 6 |pages= 1224–41 |year= 2004 |pmid= 14635195 |doi= 10.1002/jcb.10674 |name-list-format=vanc| author2=Su Y | author3=Ryder J | display-authors=3 | last4=Yan | first4=Lei | last5=Na | first5=Songqing | last6=Ni | first6=Binhui }} | ||
Revision as of 13:30, 7 November 2018
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E3 ubiquitin-protein ligase LRSAM1, previously known as Tsg101-associated ligase (Tal), is an enzyme that in humans is encoded by the LRSAM1 gene.[1][2]
Clinical significance
Mutations in LRSAM1 have been reported in the peripheral neuropathy Charcot-Marie-Tooth type 2P (OMIM 614436),[3][4][5] while disruption of the mouse Lrsam1 gene has been shown to sensitize peripheral axons to acrylamide-induced degeneration.[6]
Interactions
LRSAM1 has been shown to interact with TSG101.[7][8]
References
- ↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- ↑ "Entrez Gene: LRSAM1 leucine rich repeat and sterile alpha motif containing 1".
- ↑ Guernsey DL, Jiang H, Bedard K, Evans SC, Ferguson M, Matsuoka M, Macgillivray C, Nightingale M, Perry S, Rideout AL, Orr A, Ludman M, Skidmore DL, Benstead T, Samuels ME (August 2010). "Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease". PLoS Genet. 6 (8): e1001081. doi:10.1371/journal.pgen.1001081. PMC 2928813. PMID 20865121.
- ↑ Weterman MA, Sorrentino V, Kasher PR, Jakobs ME, van Engelen BG, Fluiter K, de Wissel MB, Sizarov A, Nürnberg G, Nürnberg P, Zelcer N, Schelhaas HJ, Baas F (January 2012). "A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy". Hum. Mol. Genet. 21 (2): 358–70. doi:10.1093/hmg/ddr471. PMC 3276280. PMID 22012984.
- ↑ Nicolaou P, Cianchetti C, Minaidou A, Marrosu G, Zamba-Papanicolaou E, Middleton L, Christodoulou K (February 2013). "A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease". Eur. J. Hum. Genet. 21 (2): 190–4. doi:10.1038/ejhg.2012.146. PMC 3548253. PMID 22781092.
- ↑ Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW (May 2013). "Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease". Dis Model Mech. 6 (3): 780–92. doi:10.1242/dmm.010942. PMC 3634660. PMID 23519028.
- ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Amit I, Yakir L, Katz M, Zwang Y, Marmor MD, Citri A, Shtiegman K, Alroy I, Tuvia S, Reiss Y, Roubini E, Cohen M, Wides R, Bacharach E, Schubert U, Yarden Y (July 2004). "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding". Genes Dev. 18 (14): 1737–52. doi:10.1101/gad.294904. PMC 478194. PMID 15256501.
Further reading
- Mazzé FM, Degrève L (2006). "The role of viral and cellular proteins in the budding of human immunodeficiency virus". Acta Virol. 50 (2): 75–85. PMID 16808324.
- Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Li B, Su Y, Ryder J, et al. (2004). "RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells". J. Cell. Biochem. 90 (6): 1224–41. doi:10.1002/jcb.10674. PMID 14635195.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Amit I, Yakir L, Katz M, et al. (2004). "Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding". Genes Dev. 18 (14): 1737–52. doi:10.1101/gad.294904. PMC 478194. PMID 15256501.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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