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'''Double-stranded RNA-binding protein Staufen homolog 2''' is a [[protein]] that in humans is encoded by the ''STAU2'' [[gene]].<ref name="pmid10585778">{{cite journal | vauthors = Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B | title = Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region | journal = Genomics | volume = 62 | issue = 1 | pages = 113–8 |date=Feb 2000 | pmid = 10585778 | pmc =  | doi = 10.1006/geno.1999.6015 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27067| accessdate = }}</ref>
'''Double-stranded RNA-binding protein Staufen homolog 2''' is a [[protein]] that in humans is encoded by the ''STAU2'' [[gene]].<ref name="pmid10585778">{{cite journal | vauthors = Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B | title = Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region | journal = Genomics | volume = 62 | issue = 1 | pages = 113–8 | date = November 1999 | pmid = 10585778 | pmc =  | doi = 10.1006/geno.1999.6015 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27067 }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles.  These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures.  Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively.  The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.<ref name="entrez" />
}}


==References==
Staufen homolog 2 is a member of the family of [[double-stranded RNA]] (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or [[organelle]]s.  These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures.  Staufen homolog 2 shares 48.5% and 59.9% similarity with ''[[drosophila]]'' and human staufen, respectively.  The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.<ref name="entrez" />
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kiebler MA, DesGroseillers L | title = Molecular insights into mRNA transport and local translation in the mammalian nervous system | journal = Neuron | volume = 25 | issue = 1 | pages = 19–28 | date = January 2000 | pmid = 10707969 | doi = 10.1016/S0896-6273(00)80868-5 }}
| citations =
* {{cite journal | vauthors = Furic L, Maher-Laporte M, DesGroseillers L | title = A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes | journal = RNA | volume = 14 | issue = 2 | pages = 324–35 | date = February 2008 | pmid = 18094122 | pmc = 2212254 | doi = 10.1261/rna.720308 }}
*{{cite journal | vauthors=Kiebler MA, DesGroseillers L |title=Molecular insights into mRNA transport and local translation in the mammalian nervous system |journal=Neuron |volume=25 |issue= 1 |pages= 19–28 |year= 2000 |pmid= 10707969 |doi=10.1016/S0896-6273(00)80868-5 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | vauthors=Furic L, Maher-Laporte M, DesGroseillers L |title=A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes |journal=RNA |volume=14 |issue= 2 |pages= 324–35 |year= 2008 |pmid= 18094122 |doi= 10.1261/rna.720308 | pmc=2212254 }}
* {{cite journal | vauthors = Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ | title = Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles | journal = Molecular and Cellular Biology | volume = 24 | issue = 7 | pages = 2637–48 | date = April 2004 | pmid = 15024055 | pmc = 371130 | doi = 10.1128/MCB.24.7.2637-2648.2004 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
* {{cite journal | vauthors = Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L | title = Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles | journal = Journal of Cell Science | volume = 115 | issue = Pt 16 | pages = 3285–95 | date = August 2002 | pmid = 12140260 | doi =  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Chatel-Chaix L, Clément JF, Martel C, etal |title=Identification of Staufen in the Human Immunodeficiency Virus Type 1 Gag Ribonucleoprotein Complex and a Role in Generating Infectious Viral Particles |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2637–48 |year= 2004 |pmid= 15024055 |doi=10.1128/MCB.24.7.2637-2648.2004 | pmc=371130  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Duchaîne TF, Hemraj I, Furic L, etal |title=Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles |journal=J. Cell Sci. |volume=115 |issue= Pt 16 |pages= 3285–95 |year= 2003 |pmid= 12140260 |doi=  }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=27067}}
{{PDB Gallery|geneid=27067}}
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Revision as of 01:20, 28 November 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.[1][2]

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.[2]

References

  1. ↑ Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B (November 1999). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region". Genomics. 62 (1): 113–8. doi:10.1006/geno.1999.6015. PMID 10585778.
  2. ↑ 2.0 2.1 "Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)".

Further reading


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