MYST3: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
(changed NCBI link to a reference.)
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}
'''MYST histone acetyltransferase (monocytic leukemia) 3''', also known as '''MYST3''', is an enzyme that, in humans, is encoded by the ''MYST3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7994| accessdate = }}</ref><ref name="pmid8782817">{{cite journal |vauthors=Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE | title = The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein | journal = Nat. Genet. | volume = 14 | issue = 1 | pages = 33–41 |date=September 1996 | pmid = 8782817 | doi = 10.1038/ng0996-33 | url = | issn = }}</ref>
'''MYST histone acetyltransferase (monocytic leukemia) 3''', also known as '''MYST3''', is an enzyme that, in humans, is encoded by the ''MYST3'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7994| accessdate = }}</ref><ref name="pmid8782817">{{cite journal |vauthors=Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE | title = The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein | journal = Nat. Genet. | volume = 14 | issue = 1 | pages = 33–41 |date=September 1996 | pmid = 8782817 | doi = 10.1038/ng0996-33 | url = | issn = }}</ref>. This gene is located on the back wing of human chromosome 8, band 8p11.21. <ref>[https://www.ncbi.nlm.nih.gov/gene/7994 - KAT6A NCBI]</ref>


== Function ==
== Function ==


MYST3 contains two nuclear localization domains, a C<sub>2</sub>HC<sub>3</sub> [[zinc finger]] and an [[acetyltransferase]] domain.  This structure suggests that MYST3 functions as a [[chromatin]]-bound acetyltransferase.<ref name="pmid8782817"/> MYST3 is important for proper development of [[haematopoiesis|hematopoietic]] [[stem cell]]s.<ref name="pmid17694082">{{cite journal |vauthors=Yang XJ, Ullah M | title = MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells | journal = Oncogene | volume = 26 | issue = 37 | pages = 5408–19 |date=August 2007 | pmid = 17694082 | doi = 10.1038/sj.onc.1210609 | url = | issn = }}</ref>
MYST3 contains two nuclear localization domains, a C<sub>2</sub>HC<sub>3</sub> [[zinc finger]] and an [[acetyltransferase]] domain.  This structure suggests that MYST3 functions as a [[chromatin]]-bound acetyltransferase.<ref name="pmid8782817"/> MYST3 is important for proper development of [[haematopoiesis|hematopoietic]] [[stem cell]]s.<ref name="pmid17694082">{{cite journal |vauthors=Yang XJ, Ullah M | title = MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells | journal = Oncogene | volume = 26 | issue = 37 | pages = 5408–19 |date=August 2007 | pmid = 17694082 | doi = 10.1038/sj.onc.1210609 | url = | issn = }}</ref>
== Alternate Names ==
*KAT6A
*MOZ
*MRD32
*MYST-3
*ZNF220
*RUNXBP2
*ZC2HC6A


==References==
==References==

Revision as of 16:32, 2 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.[1][2]. This gene is located on the back wing of human chromosome 8, band 8p11.21. [3]

Function

MYST3 contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.[2] MYST3 is important for proper development of hematopoietic stem cells.[4]

Alternate Names

  • KAT6A
  • MOZ
  • MRD32
  • MYST-3
  • ZNF220
  • RUNXBP2
  • ZC2HC6A

References

  1. "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3".
  2. 2.0 2.1 Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817.
  3. - KAT6A NCBI
  4. Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082.

Further reading