GNPTG: Difference between revisions

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Revision as of 03:15, 5 February 2018

GNPTG (“N-acetylglucosamine-1-phosphate transferase, gamma subunit.”) is a gene in the human body. It is one of three genes that were found to correlate with stuttering.

Function

The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called N-acetylglucosamine-1-phosphate transferase). This enzyme is made up of two alpha (α), two beta (β), and two gamma (γ) subunits. GNPTAB produces the alpha and beta subunits. GlcNAc-1-phosphotransferase functions to prepare newly made enzymes for lysosome transportation (lysosomal hydrolases to the lysosome). Lysosomes, a part of an animal cells, helps break down large molecules into smaller ones that can be reused. GlcNAc-1-phosphotransferase catalyzes the N-linked glycosylation of asparagine residues with a molecule called mannose-6-phosphate (M6P). M6P acts as indicator whether a hydrolase should be transported to the lysosome or not. Once a hydrolase has the indication from an M6P, it can be transported to a lysosome.

References

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+{{Infobox_gene}}
 '''GNPTG  (“N-acetylglucosamine-1-phosphate transferase, gamma subunit.”)''' is a [[gene]] in the human body. It is one of three genes that were found to correlate with [[stuttering]].
 ==Function==
-The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called [[N-acetylglucosamine-1-phosphate transferase]]). This enzyme is made up of two [[Alpha particle|alpha]] (α), two [[Beta particle|beta]] (β), and two [[G beta-gamma complex|gamma]] (γ) subunits. GNPTAB produces the alpha and beta subunits. GlcNAc-1-phosphotransferase functions to prepare newly made enzymes for lysosome transportation (lysosomal hydrolases to the lysosome). [[Lysosome]]s, a part of an animal cells, helps break down large molecules into smaller ones that can be reused. GlcNAc-1-phosphotransferase catalyzes the N-linked [[glycosylation]] of asparagine residues with a molecule called [[mannose-6-phosphate]] (M6P). M6P acts as indicator whether a hydrolase should be transported to the lysosome or not. Once a hydrolase has the indication from an M6P, it can be transported to a lysosome.
+The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called [[N-acetylglucosamine-1-phosphate transferase]]). This enzyme is made up of two alpha (α), two beta (β), and two gamma (γ) [[protein subunit|subunit]]s. GNPTAB produces the alpha and beta subunits. GlcNAc-1-phosphotransferase functions to prepare newly made enzymes for lysosome transportation (lysosomal hydrolases to the lysosome). [[Lysosome]]s, a part of an animal cells, helps break down large molecules into smaller ones that can be reused. GlcNAc-1-phosphotransferase catalyzes the [[N-linked glycosylation|''N''-linked glycosylation]] of asparagine residues with a molecule called [[mannose-6-phosphate]] (M6P). M6P acts as indicator whether a hydrolase should be transported to the lysosome or not. Once a hydrolase has the indication from an M6P, it can be transported to a lysosome.
-==Location==
-The GNPTG gene is located in chromosome 16 at position 13.3.
-<ref>{{cite web|title=N-acetylglucosamine-1-phosphate transferase, gamma subunit|url=http://www.genecards.org/cgi-bin/carddisp.pl?gene=GNPTG|work=Gene Cards|accessdate=2013-06-06}}</ref><ref>{{cite web|title=GNPTG|url=http://ghr.nlm.nih.gov/gene/GNPTG|work=Genetics Home Reference|accessdate=2013-06-06}}</ref>
 ==References==

GNPTG: Difference between revisions

Revision as of 03:15, 5 February 2018

Function

References

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