ZNRF1: Difference between revisions
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'''E3 ubiquitin-protein ligase ZNRF1''' is an [[enzyme]] that in humans is encoded by the ''ZNRF1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNRF1 zinc and ring finger 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84937| accessdate = }}</ref> | '''E3 ubiquitin-protein ligase ZNRF1''' is an [[enzyme]] that in humans is encoded by the ''ZNRF1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNRF1 zinc and ring finger 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84937| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = In a study identifying genes in rat that are [[upregulated]] in response to [[nerve damage]], a gene which is highly expressed in [[ganglia]] and in the [[central nervous system]] was found. The | | summary_text = In a study identifying genes in rat that are [[upregulated]] in response to [[nerve damage]], a gene which is highly expressed in [[ganglia]] and in the [[central nervous system]] was found. The protein encoded by the rat gene contains both a [[zinc finger]] and a RING finger motif and is localized in the [[endosome]]/[[lysosome]] compartment, indicating that it may be involved in [[ubiquitin]]-mediated [[protein modification]]. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.<ref name="entrez"/> | ||
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Revision as of 18:28, 13 February 2018
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E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.[1]
In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.[1]
References
Further reading
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Araki T, Nagarajan R, Milbrandt J (2001). "Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery". J. Biol. Chem. 276 (36): 34131–41. doi:10.1074/jbc.M104271200. PMID 11427537.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Araki T, Milbrandt J (2003). "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases". J. Neurosci. 23 (28): 9385–94. PMID 14561866.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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