CNOT1: Difference between revisions

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'''CCR4-NOT transcription complex subunit 1''' is a [[protein]] that in humans is encoded by the ''CNOT1'' [[gene]].<ref name="pmid14702039">{{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–5 | year = 2004 | date = December 2003 | pmid = 14702039 | pmc =  | doi = 10.1038/ng1285 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23019| accessdate = }}</ref>
'''CCR4-NOT transcription complex subunit 1''' is a [[protein]] that in humans is encoded by the ''CNOT1'' [[gene]].<ref name="pmid14702039">{{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S|display-authors = 6 | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nature Genetics | volume = 36 | issue = 1 | pages = 40–5 | date = January 2004 | pmid = 14702039 | doi = 10.1038/ng1285 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23019| accessdate = }}</ref>


It is a part of the Ccr4-Not complex, which [[deadenylation|deadenylates]] [[mRNA]]s.<ref>{{cite journal | vauthors = Garneau NL, Wilusz J, Wilusz CJ | title = The highways and byways of mRNA decay | journal = Nat. Rev. Mol. Cell Biol. | volume = 8 | issue = 2 | pages = 113–26  | date = Feb 2007 | pmid = 17245413 | doi = 10.1038/nrm2104 }}</ref>  CNOT1 acts as a scaffold protein, binding other subunits of the complex.<ref>{{cite journal | vauthors = Sandler H, Kreth J, Timmers HT, Stoecklin G | title = Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin | journal = Nucleic Acids Res. | volume = 39 | issue = 10 | pages = 4373–86  | date = May 2011 | pmid = 21278420 | pmc = 3105394 | doi = 10.1093/nar/gkr011 }}</ref><ref>{{cite journal | vauthors = Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O | title = The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex | journal = Nucleic Acids Res. | volume = 40 | issue = 21 | pages = 11058–72  | date = Nov 2012 | pmid = 22977175 | pmc = 3510486 | doi = 10.1093/nar/gks883 }}</ref><ref>{{cite journal | vauthors = Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E | title = Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction | journal = Mol. Cell | volume = 48 | issue = 2 | pages = 207–18  | date = Oct 26, 2012 | pmid = 22959269 | doi = 10.1016/j.molcel.2012.08.014 }}</ref>
It is a part of the Ccr4-Not complex, which [[deadenylation|deadenylates]] [[mRNA]]s.<ref>{{cite journal | vauthors = Garneau NL, Wilusz J, Wilusz CJ | title = The highways and byways of mRNA decay | journal = Nat. Rev. Mol. Cell Biol. | volume = 8 | issue = 2 | pages = 113–26  | date = Feb 2007 | pmid = 17245413 | doi = 10.1038/nrm2104 }}</ref>  CNOT1 acts as a scaffold protein, binding other subunits of the complex.<ref>{{cite journal | vauthors = Sandler H, Kreth J, Timmers HT, Stoecklin G | title = Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin | journal = Nucleic Acids Res. | volume = 39 | issue = 10 | pages = 4373–86  | date = May 2011 | pmid = 21278420 | pmc = 3105394 | doi = 10.1093/nar/gkr011 }}</ref><ref>{{cite journal | vauthors = Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O | title = The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex | journal = Nucleic Acids Res. | volume = 40 | issue = 21 | pages = 11058–72  | date = Nov 2012 | pmid = 22977175 | pmc = 3510486 | doi = 10.1093/nar/gks883 }}</ref><ref>{{cite journal | vauthors = Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E | title = Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction | journal = Mol. Cell | volume = 48 | issue = 2 | pages = 207–18  | date = Oct 26, 2012 | pmid = 22959269 | doi = 10.1016/j.molcel.2012.08.014 }}</ref>
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* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 6 | issue = 1 | pages = 63–70 | year = 1999 | pmid = 10231032 | doi = 10.1093/dnares/6.1.63 }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 6 | issue = 1 | pages = 63–70 | year = 1999 | pmid = 10231032 | doi = 10.1093/dnares/6.1.63 }}
* {{cite journal | vauthors = Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT | title = Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits | journal = Nucleic Acids Res. | volume = 28 | issue = 3 | pages = 809–17 | year = 2000 | pmid = 10637334 | pmc = 102560 | doi = 10.1093/nar/28.3.809 }}
* {{cite journal | vauthors = Chen J, Rappsilber J, Chiang YC, Russell P, Mann M, Denis CL | title = Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex | journal = J. Mol. Biol. | volume = 314 | issue = 4 | pages = 683–94 | year = 2001 | pmid = 11733989 | doi = 10.1006/jmbi.2001.5162 }}
* {{cite journal | vauthors = Chen J, Rappsilber J, Chiang YC, Russell P, Mann M, Denis CL | title = Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex | journal = J. Mol. Biol. | volume = 314 | issue = 4 | pages = 683–94 | year = 2001 | pmid = 11733989 | doi = 10.1006/jmbi.2001.5162 }}
* {{cite journal | vauthors = Laveder P, De Pittà C, Toppo S, Valle G, Lanfranchi G | title = A two-step strategy for constructing specifically self-subtracted cDNA libraries | journal = Nucleic Acids Res. | volume = 30 | issue = 9 | pages = e38 | year = 2002 | pmid = 11972353 | pmc = 113861 | doi = 10.1093/nar/30.9.e38 }}
* {{cite journal | vauthors = Laveder P, De Pittà C, Toppo S, Valle G, Lanfranchi G | title = A two-step strategy for constructing specifically self-subtracted cDNA libraries | journal = Nucleic Acids Res. | volume = 30 | issue = 9 | pages = e38 | year = 2002 | pmid = 11972353 | pmc = 113861 | doi = 10.1093/nar/30.9.e38 }}

Revision as of 09:59, 2 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
CCR4-Not complex component, Not1
Identifiers
SymbolNot1
PfamPF04054
InterProIPR007196

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.[1][2]

It is a part of the Ccr4-Not complex, which deadenylates mRNAs.[3] CNOT1 acts as a scaffold protein, binding other subunits of the complex.[4][5][6]

Interactions

CNOT1 has been shown to interact with CNOT8.[7][8]

References

  1. ↑ Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  2. ↑ "Entrez Gene: CNOT1 CCR4-NOT transcription complex, subunit 1".
  3. ↑ Garneau NL, Wilusz J, Wilusz CJ (Feb 2007). "The highways and byways of mRNA decay". Nat. Rev. Mol. Cell Biol. 8 (2): 113–26. doi:10.1038/nrm2104. PMID 17245413.
  4. ↑ Sandler H, Kreth J, Timmers HT, Stoecklin G (May 2011). "Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin". Nucleic Acids Res. 39 (10): 4373–86. doi:10.1093/nar/gkr011. PMC 3105394. PMID 21278420.
  5. ↑ Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O (Nov 2012). "The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex". Nucleic Acids Res. 40 (21): 11058–72. doi:10.1093/nar/gks883. PMC 3510486. PMID 22977175.
  6. ↑ Basquin J, Roudko VV, Rode M, Basquin C, Séraphin B, Conti E (Oct 26, 2012). "Architecture of the nuclease module of the yeast Ccr4-not complex: the Not1-Caf1-Ccr4 interaction". Mol. Cell. 48 (2): 207–18. doi:10.1016/j.molcel.2012.08.014. PMID 22959269.
  7. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  8. ↑ Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Res. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=CNOT1&oldid=1524692"