'''Target of rapamycin complex subunit LST8''', also known as '''mammalian lethal with SEC13 protein 8''' (mLST8) or '''TORC subunit LST8''' or '''G protein beta subunit-like''' (GβL or Gable), is a [[protein]] that in humans is encoded by the ''MLST8'' (MTOR associated protein, LST8 homolog) [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTOR associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64223| accessdate = }}</ref> It is a subunit of both [[mTORC1]] and [[mTORC2]], complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.<ref>{{cite web | title = UniProtKB – Q9BVC4 (LST8_HUMAN) | url = http://www.uniprot.org/uniprot/Q9BVC4 | accessdate = }}</ref> It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.<ref>{{cite journal | vauthors = Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C | title = mLST8 Promotes mTOR-Mediated Tumor Progression | journal = PLOS ONE | date = 23 Apr 2015 | doi = 10.1371/journal.pone.0119015 | url = http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0119015}}</ref>
'''Target of rapamycin complex subunit LST8''', also known as '''mammalian lethal with SEC13 protein 8''' (mLST8) or '''TORC subunit LST8''' or '''G protein beta subunit-like''' (GβL or Gable), is a [[protein]] that in humans is encoded by the ''MLST8'' (MTOR associated protein, LST8 homolog) [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTOR associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64223| accessdate = }}</ref> It is a subunit of both [[mTORC1]] and [[mTORC2]], complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.<ref>{{cite web | title = UniProtKB – Q9BVC4 (LST8_HUMAN) | url = https://www.uniprot.org/uniprot/Q9BVC4 | accessdate = }}</ref> It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.<ref>{{cite journal | vauthors = Kakumoto K, Ikeda J, Okada M, Morii E, Oneyama C | title = mLST8 Promotes mTOR-Mediated Tumor Progression | journal = PLOS ONE | date = 23 Apr 2015 | doi = 10.1371/journal.pone.0119015 | url = http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0119015}}</ref>
Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.[1] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.[2] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.[3]
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