Hepatocellular adenoma medical therapy: Difference between revisions
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* Historically, hepatocellular adenomas were treated with a wait and watch policy, with surgical intervention recommended for larger (>5cm) tumors. | * Historically, hepatocellular adenomas were treated with a wait and watch policy, with surgical intervention recommended for larger (>5cm) tumors. | ||
* In asymptomatic female patients of hepatocellular adenomas , the first step is to stop the offending drug (OCPs) and check adenoma size on followup. | * In asymptomatic female patients of hepatocellular adenomas , the first step is to stop the offending drug (OCPs) and check adenoma size on followup. | ||
* The wait and watch policy is recommended when hepatocellular adenomas are <5cm or regress (to <5cm) following cessation of offending drug (OCPs) and no further growth detected. | * The wait and watch policy is recommended when hepatocellular adenomas are <5cm or regress (to <5cm) following cessation of offending drug (OCPs) and no further growth detected.<ref>{{Cite journal | ||
* An yearly followup with MRI or ultrasound is scheduled for patients untill menopause.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref> | | author = [[Maarten G. Thomeer]], [[Mirelle Broker]], [[Joanne Verheij]], [[Michael Doukas]], [[Turkan Terkivatan]], [[Diederick Bijdevaate]], [[Robert A. De Man]], [[Adriaan Moelker]] & [[Jan N. IJzermans]] | ||
| title = Hepatocellular adenoma: when and how to treat? Update of current evidence | |||
| journal = [[Therapeutic advances in gastroenterology]] | |||
| volume = 9 | |||
| issue = 6 | |||
| pages = 898–912 | |||
| year = 2016 | |||
| month = November | |||
| doi = 10.1177/1756283X16663882 | |||
| pmid = 27803743 | |||
}}</ref> | |||
* An yearly followup with MRI or ultrasound is scheduled for patients untill menopause.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188 }} </ref><ref>{{Cite journal | |||
| author = [[A. F. Mariani]], [[A. S. Livingstone]], [[R. V. Jr Pereiras]], [[P. E. van Zuiden]] & [[E. R. Schiff]] | |||
| title = Progressive enlargement of an hepatic cell adenoma | |||
| journal = [[Gastroenterology]] | |||
| volume = 77 | |||
| issue = 6 | |||
| pages = 1319–1325 | |||
| year = 1979 | |||
| month = December | |||
| pmid = 499719 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[P. H. Andersen]] & [[J. T. Packer]] | |||
| title = Hepatic adenoma. Observations after estrogen withdrawal | |||
| journal = [[Archives of surgery (Chicago, Ill. : 1960)]] | |||
| volume = 111 | |||
| issue = 8 | |||
| pages = 898–900 | |||
| year = 1976 | |||
| month = August | |||
| pmid = 182106 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[S. Kay]] | |||
| title = Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives | |||
| journal = [[Cancer]] | |||
| volume = 40 | |||
| issue = 4 | |||
| pages = 1759–1760 | |||
| year = 1977 | |||
| month = October | |||
| pmid = 198104 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[P. Aseni]], [[C. V. Sansalone]], [[C. Sammartino]], [[F. D. Benedetto]], [[G. Carrafiello]], [[A. Giacomoni]], [[C. Osio]], [[M. Vertemati]] & [[D. Forti]] | |||
| title = Rapid disappearance of hepatic adenoma after contraceptive withdrawal | |||
| journal = [[Journal of clinical gastroenterology]] | |||
| volume = 33 | |||
| issue = 3 | |||
| pages = 234–236 | |||
| year = 2001 | |||
| month = September | |||
| pmid = 11500616 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[H. Buhler]], [[M. Pirovino]], [[A. Akobiantz]], [[J. Altorfer]], [[M. Weitzel]], [[E. Maranta]] & [[M. Schmid]] | |||
| title = Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use | |||
| journal = [[Gastroenterology]] | |||
| volume = 82 | |||
| issue = 4 | |||
| pages = 775–782 | |||
| year = 1982 | |||
| month = April | |||
| pmid = 6277724 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[B. Heeringa]] & [[A. Sardi]] | |||
| title = Bleeding hepatic adenoma: expectant treatment to limit the extent of liver resection | |||
| journal = [[The American surgeon]] | |||
| volume = 67 | |||
| issue = 10 | |||
| pages = 927–929 | |||
| year = 2001 | |||
| month = October | |||
| pmid = 11603546 | |||
}}</ref> | |||
==References== | ==References== | ||
Revision as of 15:58, 10 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]
Overview
There is no specific medical therapy for the hepatocellular adenomas. The wait and watch policy is recommended for hepatocellular adenoams <5cm following cessation of offending drugs (OCPs) and no further growth detected. Annual followup is scheduled with MRI or ultrasound until menopause.
Hepatocellular adenoma medical therapy
- There is no specific medical therapy for the hepatocellular adenoma.[1][2]
- Historically, hepatocellular adenomas were treated with a wait and watch policy, with surgical intervention recommended for larger (>5cm) tumors.
- In asymptomatic female patients of hepatocellular adenomas , the first step is to stop the offending drug (OCPs) and check adenoma size on followup.
- The wait and watch policy is recommended when hepatocellular adenomas are <5cm or regress (to <5cm) following cessation of offending drug (OCPs) and no further growth detected.[3]
- An yearly followup with MRI or ultrasound is scheduled for patients untill menopause.[4][5][6][7][8][9][10]
References
- ↑ Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors". World J Gastroenterol. 11 (36): 5691–5. PMID 16237767.Full text
- ↑ Ault GT, Wren SM, Ralls PW, Reynolds TB, Stain SC (1996). "Selective management of hepatic adenomas". Am Surg. 62 (10): 825–9. PMID 8813164.
- ↑ Maarten G. Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A. De Man, Adriaan Moelker & Jan N. IJzermans (2016). "Hepatocellular adenoma: when and how to treat? Update of current evidence". Therapeutic advances in gastroenterology. 9 (6): 898–912. doi:10.1177/1756283X16663882. PMID 27803743. Unknown parameter
|month=ignored (help) - ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
- ↑ A. F. Mariani, A. S. Livingstone, R. V. Jr Pereiras, P. E. van Zuiden & E. R. Schiff (1979). "Progressive enlargement of an hepatic cell adenoma". Gastroenterology. 77 (6): 1319–1325. PMID 499719. Unknown parameter
|month=ignored (help) - ↑ P. H. Andersen & J. T. Packer (1976). "Hepatic adenoma. Observations after estrogen withdrawal". Archives of surgery (Chicago, Ill. : 1960). 111 (8): 898–900. PMID 182106. Unknown parameter
|month=ignored (help) - ↑ S. Kay (1977). "Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives". Cancer. 40 (4): 1759–1760. PMID 198104. Unknown parameter
|month=ignored (help) - ↑ P. Aseni, C. V. Sansalone, C. Sammartino, F. D. Benedetto, G. Carrafiello, A. Giacomoni, C. Osio, M. Vertemati & D. Forti (2001). "Rapid disappearance of hepatic adenoma after contraceptive withdrawal". Journal of clinical gastroenterology. 33 (3): 234–236. PMID 11500616. Unknown parameter
|month=ignored (help) - ↑ H. Buhler, M. Pirovino, A. Akobiantz, J. Altorfer, M. Weitzel, E. Maranta & M. Schmid (1982). "Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use". Gastroenterology. 82 (4): 775–782. PMID 6277724. Unknown parameter
|month=ignored (help) - ↑ B. Heeringa & A. Sardi (2001). "Bleeding hepatic adenoma: expectant treatment to limit the extent of liver resection". The American surgeon. 67 (10): 927–929. PMID 11603546. Unknown parameter
|month=ignored (help)